Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering

Adithya, S. Pranav; Sidharthan, D. Saleth; Abhinandan, R.; Balagangadharan, K.; Selvamurugan, N.

doi:10.1016/j.ijbiomac.2020.08.053

Cited by 51 publications

(23 citation statements)

References 195 publications

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“…For this reason, composite scaffolds made of synthetic and natural polymers can provide these properties better than any alone 25 . In fact, they have good mechanical strength derived from synthetic polymers and have good biocompatibility and biodegradability due to the presence of natural polymers 26 …”

Section: Discussionmentioning

confidence: 99%

Curcumin‐loaded PHB/PLLA nanofibrous scaffold supports osteogenesis in adipose‐derived stem cells in vitro

Abazari

Karizi

Hajati-Birgani

et al. 2021

Polymers for Advanced Techs

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One of the most important goals of bone tissue engineering is to regenerate damaged tissue and improve its function by making three‐dimensional scaffolds. This role becomes more important and efficient when it can release a biologically active factor at the site of the lesion. In the present study, poly(3‐hydroxybutyrate)/poly(l‐lactic acid) nanofibers (PHB/PLLA) and curcumin‐incorporated PHB/PLLA nanofibers (cur‐PHB/PLLA) were fabricated using electrospinning. After morphological and biological characterization, and Curcumin release assessment, the osteogenic differentiation potential of the human adipose–derived stem cells (ADSCs) was investigated with the evaluation of the common osteogenic markers. Fabricated nanofibers were smooth, bead free, and with continuous release of curcumin. The biocompatibility of the fabricated nanofibers was improved while incorporated with curcumin compared to the empty nanofibers. Besides, evaluation of the alkaline phosphatase (ALP) activity, calcium content, and osteogenic‐related gene expression revealed that the PHB/PLLA mat can support osteogenic differentiation of the ADSCs more efficiently while incorporated with curcumin. Based on the results, it can be concluded that cur‐PHB/PLLA has promising potential for use in the treatment of the bone lesions and/or bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Curcumin‐loaded PHB/PLLA nanofibrous scaffold supports osteogenesis in adipose‐derived stem cells in vitro

Abazari

Karizi

Hajati-Birgani

et al. 2021

Polymers for Advanced Techs

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“…In recent years, the synthesis of new composites based on natural compounds for various applications has received much attention [ 11 , 12 , 13 ]. In this regard, in this work, for the first time, the magnetic composite of spongin was synthesized using a simple method in ambient temperature and pressure, and was used to remove MB and CV dyes.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

et al. 2021

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The renewable, proteinaceous, marine biopolymer spongin is yet the focus of modern research. The preparation of a magnetic three-dimensional (3D) spongin scaffold with nano-sized Fe3O4 cores is reported here for the first time. The formation of this magnetic spongin–Fe3O4 composite was characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential thermal analysis (DTA) (TGA-DTA), vibrating sample magnetometer (VSM), Fourier-transform infrared spectroscopy (FTIR), and zeta potential analyses. Field emission scanning electron microscopy (FE-SEM) confirmed the formation of well-dispersed spherical nanoparticles tightly bound to the spongin scaffold. The magnetic spongin–Fe3O4 composite showed significant removal efficiency for two cationic dyes (i.e., crystal violet (CV) and methylene blue (MB)). Adsorption experiments revealed that the prepared material is a fast, high-capacity (77 mg/g), yet selective adsorbent for MB. This behavior was attributed to the creation of strong electrostatic interactions between the spongin–Fe3O4 and MB or CV, which was reflected by adsorption mechanism evaluations. The adsorption of MB and CV was found to be a function of pH, with maximum removal performance being observed over a wide pH range (pH = 5.5–11). In this work, we combined Fe3O4 nanoparticles and spongin scaffold properties into one unique composite, named magnetic spongin scaffold, in our attempt to create a sustainable absorbent for organic wastewater treatment. The appropriative mechanism of adsorption of the cationic dyes on a magnetic 3D spongin scaffold is proposed. Removal of organic dyes and other contaminants is essential to ensure healthy water and prevent various diseases. On the other hand, in many cases, dyes are used as models to demonstrate the adsorption properties of nanostructures. Due to the good absorption properties of magnetic spongin, it can be proposed as a green and uncomplicated adsorbent for the removal of different organic contaminants and, furthermore, as a carrier in drug delivery applications.

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“…Bone tissue engineering is considered a radical and hopeful approach for repairing bone defects as it depends on tissue regeneration rather than tissue replacement [7]. A variety of biomaterials derived from natural or synthetic polymers and bioactive glasses have been used over the past few decades to generate different forms of 3D networks, such as hydrogels, fibers, and implants, besides a wide variety of drug delivery systems [8]. Among the designed drug delivery systems, in situ forming implants (IFIs) provide an attractive potential for the controlled treatment of bone defects.…”

Section: Introductionmentioning

confidence: 99%

Dual-Drug Delivery via Zein In Situ Forming Implants Augmented with Titanium-Doped Bioactive Glass for Bone Regeneration: Preparation, In Vitro Characterization, and In Vivo Evaluation

et al. 2022

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In situ forming implants (IFIs) are non-surgical approach using biodegradable polymers to treat bone fractures. The study aimed at preparing dual-drug-loaded IFIs to deliver pitavastatin (osteogenic drug) and tedizolid (antibiotic) using zein as the implant matrix via solvent-induced phase inversion method. At first, several investigations were done on pitavastatin-loaded zein IFIs, where three concentrations of zein were used (10, 20, and 30% w/v). IFIs were evaluated for their solidification time, rheological properties, injectability, and in vitro release. IFIs containing bioactive glass nanoparticles were prepared by the addition of non-doped bioactive glass nanoparticles (BGT0; 1, 3, 5, and 10% w/v) or titanium-doped bioactive glass nanoparticles (BGT5; 1% w/v) to the selected concentration of zein (30% w/v) and then evaluated. The optimized dual-medicated implant (D-ZIFI 1) containing pitavastatin, tedizolid, sodium hyaluronate (3% w/v), and BGT5 (1% w/v) was prepared and compared to IFI lacking both sodium hyaluronate and BGT5 (D-ZIFI 2). D-ZIFI 1 and 2 sustained the release profiles of both drugs for 28 days. SEM images proved the interconnected porous structure of D-ZIFI 1 due to sodium hyaluronate. In vivo studies on surgically induced bone defects in Sprague–Dawley rats signified the proper accelerated bone healing ability of D-ZIFI 1 over D-ZIFI 2. Results presented D-ZIFI 1 as a promising, effective, non-surgical approach for bone healing.

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Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering

Cited by 51 publications

References 195 publications

Curcumin‐loaded PHB/PLLA nanofibrous scaffold supports osteogenesis in adipose‐derived stem cells in vitro

Curcumin‐loaded PHB/PLLA nanofibrous scaffold supports osteogenesis in adipose‐derived stem cells in vitro

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

Dual-Drug Delivery via Zein In Situ Forming Implants Augmented with Titanium-Doped Bioactive Glass for Bone Regeneration: Preparation, In Vitro Characterization, and In Vivo Evaluation

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