Naringenin as a potential immunomodulator in therapeutics

Zeng, Wenfeng; Jin, Lingtao; Zhang, Fayun; Zhang, Chunyu; Liang, Wei

doi:10.1016/j.phrs.2018.08.002

Cited by 215 publications

(122 citation statements)

References 97 publications

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“…Naringenin (4,5,7‐trihydroxyflavone; Figure a) is a flavonoid compound found in plants and is abundant in citrus fruits, especially grapefruit (Orhan et al, ). In recent years, naringenin has been shown to exert a range of biological effects, including anti‐inflammation (Jin, Zeng, Zhang, Zhang, & Liang, ), anti‐oxidation (Zhao et al, ), hypolipidaemic effects (Mulvihill et al, ), immunoregulation (Zeng et al, ), and antineoplastic activity (Ke et al, ). Moreover, naringenin ameliorated obesity (Burke et al, ), metabolic syndrome (Alam et al, ), diabetes (Al‐Dosari, Ahmed, Al‐Rejaie, Alhomida, & Ola, ), and atherosclerosis (Mulvihill et al, , a).…”

Section: Introductionmentioning

confidence: 99%

Naringenin attenuates non‐alcoholic fatty liver disease by down‐regulating the NLRP3/NF‐κB pathway in mice

Wang

et al. 2020

British J Pharmacology

184

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Background and Purpose Naringenin, a flavonoid compound with strong anti‐inflammatory activity, attenuated non‐alcoholic fatty liver disease (NAFLD) induced by a methionine‐choline deficient (MCD) diet in mice. However, the mechanisms underlying this suppression of inflammation and NAFLD remain unknown. Experimental Approach WT and NLRP3−/− mice were fed with MCD diet for 7 days to induce NAFLD and were given naringenin by gavage at the same time. in vitro experiments used HepG2 cells, primary hepatocytes, and Kupffer cells (KCs) stimulated by LPS or LPS plus oleic acid (OA). Key Results Treating WT mice with naringenin (100 mg·kg−1·day−1) attenuated hepatic lipid accumulation and inflammation in the livers of mice given the MCD diet. NLRP3−/− mice showed less hepatic lipid accumulation than WT mice, but naringenin did not ameliorate hepatic lipid accumulation further in NLRP3−/− mice. Treating the HepG2 cells with naringenin or NLRP3 inhibitor MCC950 reduced lipid accumulation. Naringenin inhibited activation of the NLRP3/NF‐κB pathway stimulated by OA together with LPS. In KCs isolated from WT mice, naringenin inhibited NLRP3 expression. Naringenin also inhibited lipid deposition, NLRP3 and IL‐1β expression in WT hepatocytes but was not effective in NLRP3−/− hepatocytes. After re‐expressing NLRP3 in NLRP3−/− hepatocytes by adenovirus, the anti‐lipid deposition effect of naringenin was restored. Conclusion and Implications Naringenin prevented NAFLD via down‐regulating the NLRP3/NF‐κB signalling pathway both in KCs and in hepatocytes, thus attenuating inflammation in the mice livers.

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Section: Introductionmentioning

confidence: 99%

Naringenin attenuates non‐alcoholic fatty liver disease by down‐regulating the NLRP3/NF‐κB pathway in mice

Wang

et al. 2020

British J Pharmacology

184

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“…Naringenin, that is, the aglycone of naringin, is one of the best studied among the flavanones. It is mainly found in Citrus fruits, and a number of papers has highlighted its potential use in health conditions such as oxidative stress, inflammation, neurological disorders, and particularly cardiovascular/metabolic diseases (Salehi, Fokou, et al, 2019;Zeng, Jin, Zhang, Zhang, & Liang, 2018). The daily mean intake of naringenin has been estimated to be 58.1 mg (Ranka et al, 2008).…”

Section: Flavanonesmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

611

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…After the ADME screening, 23 active compounds from Ephedra (Supplementary Date Table 1) and 92 active compounds from Glycyrrhiza (Supplementary Date Table 2) were obtained in TCMSP. Among the 23 compounds of ephedra, the flavonoids eriodictyol, naringenin and leucopelargonidin (OB ≥ 50%) have the effects of antiinflammation, immunoregulation and antioxidant stress [25][26][27][28]. In Glycyrrhiza, 42…”

Section: Active Compounds Analysismentioning

confidence: 99%

Chemical composition and pharmacological mechanism of Ephedra-Glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)

Qiu

Lin

et al. 2020

Preprint

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Background: Coronavirus disease 2019 (COVID-19) is currently spreading all over the world, and the prospect of a very rapid increase in COVID-19 cases prompted us to seek effective antiviral therapeutics, from the identification of possible drugs to their potential mechanisms. Purpose: The aim of this study was to explore the efficacy of the Ephedra-Glycyrrhiza (EG) drug pair on coronavirus disease 2019 (COVID-19) by network pharmacology and molecular docking. Methods: The main active compounds, target information, meridians and properties of EG were obtained through the TCMSP and ETCM databases. The targeted information of COVID-19 was acquired from the GeneCards database. EG drug pair applied diseases were analysed by DAVID and the drug-bank database, and visualized by Rstudio and Cytoscape 3.7.2. Then, we carried out targeted intersection of the EG drug pair and COVID-19 to map the compound-target-disease interactions and visualize them with Cytoscape 3.7.2 and Venny 2.1. In addition, the enrichment analysis of the GO and KEGG pathways were visualized with Rstudio and PathVisio software through the DAVID database. Finally, we carried out the molecular docking of the EG active compounds with M hydrolase (Mpro), spike protein (S protein) and angiotensin-converting enzyme 2 (ACE2), and the binding modes between GE and the protein were verified via molecular dynamics (MD) simulation. Results: We identified 112 active EG compounds by network pharmacological analysis. Drug pair enrichment analysis demonstrated that these compounds may participate in the cAMP, PI3K-Akt, JAK-STAT and chemokine signalling pathways, which had a high correlation with respiratory system, nervous system, blood circulation system and digestive system related diseases. Pathway analysis between EG and COVID-19 showed that the key targets were TNF, IL2, FOS, ALB and PTGS2. They may regulate the PI3K-Akt signalling pathway and natural killer cell-mediated cytotoxicity to play roles in immune regulation, organ protection, antiviral, immune regulation, and organ protection as well as having antiviral effects. Molecular docking results showed that the active EG compounds bind well to Mpro, S protein and ACE2. The binding modes between the active compounds of the EG and protein were verified via MD simulation. Conclusion: The EG drug pair can treat COVID-19 through multiple targets and pathways, which can provide a theoretical basis for further study of the mechanism of action of the EG drug pair on COVID-19.

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Naringenin as a potential immunomodulator in therapeutics

Cited by 215 publications

References 97 publications

Naringenin attenuates non‐alcoholic fatty liver disease by down‐regulating the NLRP3/NF‐κB pathway in mice

Naringenin attenuates non‐alcoholic fatty liver disease by down‐regulating the NLRP3/NF‐κB pathway in mice

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Chemical composition and pharmacological mechanism of Ephedra-Glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)

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