The extent to which climate change
and other factors will influence building energy use and population exposures
to indoor pollutants is not well understood. Here, we develop and
apply nationally representative residential energy and indoor pollutant
model sets to estimate energy use, indoor pollutant concentrations,
and associated chronic health outcomes across the U.S. residential
building stock in the mid-21st century. The models incorporate expected
changes in meteorological and ambient air quality conditions associated
with IPCC RCP 8.5 and assumptions for changes in housing characteristics
and population movements while keeping other less predictable factors
constant. Site and source
energy consumption for residential space-conditioning are predicted
to decrease by ∼37–43 and ∼20–31%, respectively,
in the 2050s compared to those in a 2010s reference scenario. Population-average
indoor concentrations of pollutants of ambient origin are expected
to decrease, except for O3. Holding indoor emission factors
constant, indoor concentrations of pollutants with intermittent indoor
sources are expected to decrease by <5% (PM2.5) to >30%
(NO2); indoor concentrations of pollutants with persistent
indoor sources (e.g., volatile organic compounds (VOCs)) are predicted
to increase by ∼15–45%. We estimate negligible changes
in disability-adjusted life-years (DALYs) lost associated with residential
indoor pollutant exposures, well within uncertainty, although the
attribution among pollutants is predicted to vary.