Nausea and Vomiting in Pregnancy—A Contribution to Its Epidemiology

Järnfelt-Samsioe, Ann; Samsioe, Güoran; Velinder, Gun-Marie

doi:10.1097/00006254-198407000-00004

Cited by 17 publications

(34 citation statements)

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“…We were able to confirm the findings of previous authors that there is no significant relation between symp toms of pregnancy sickness and pre-eclamptic toxaemia in the current pregnancy [6,9,11], pregnancy weight gain [2,3], the sex of the baby [1,2,12] or the birth weight of the baby [2,9] (table 1, 2). This is in contrast with the findings of low birth weight babies in hyperemesis gravi darum, particularly severe hyperemesis [4,13], The present study confirms the significant relation between pregnancy nausea in the current pregnancy and the occurrence of pregnancy sickness in previous pregnan cies [9] (table 1).…”

Section: Discussionsupporting

confidence: 88%

“…However, our results do not agree with the findings of oth er authors who recorded an increased incidence of preg nancy sickness related to the following items: younger age [9,13,15]; maternal obesity [5,9], and primiparity [4,9,13] women who have had nausea while taking oral contra ceptive treatment [1,6,12]. Other authors agreed with our finding of no increase in the incidence of pregnancy sickness symptoms with maternal age [1,4,6], initial body weight [1], parity [12] and alcohol consumption [2], We suggest that our results differ in some respects from those of other authors [1, 2, 4-6, 9, 12-15] because we have been able to collect the data from prospective daily diaries throughout early pregnancy and enter the results into the analysis as a continuous variable.…”

contrasting

confidence: 99%

“…In previous papers relating pregnancy sickness to other pregnancy-associated factors, results have depended on dividing women into groups either with the presence or absence of symptoms [1,2], or with other methods for grading the severity of symptoms [3][4][5][6]. As we have shown in a previous article [7], there is such a great varia tion in the severity of pregnancy sickness symptoms in every pregnancy that the assessment of these symptoms as a continuous variable is preferable.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy Nausea Related to Women’s Obstetric and Personal Histories

Gadsby

Barnie-Adshead²,

Jagger

1997

Gynecol Obstet Invest

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We report the correlation between total hours of nausea in early pregnancy, as a continuous variable, and various factors in women’s obstetric and personal histories. Positive correlations for increased nausea were found with heavier placentae (p = 0.005), non-smoking status (p = 0.004), women with nausea in previous pregnancies (p = 0.005), and women whose mothers experienced trouble with nausea in their pregnancies (p = 0.001). 17 other factors did not relate to pregnancy nausea at the p < 0.01 level.

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Section: Discussionsupporting

confidence: 88%

contrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy Nausea Related to Women’s Obstetric and Personal Histories

Gadsby

Barnie-Adshead²,

Jagger

1997

Gynecol Obstet Invest

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“…Nausea and vomiting during pregnancy are extremely common [1,2]. The causal fac tors are still obscure.…”

Section: Discussionmentioning

confidence: 99%

“…Although nausea and vomiting during the early months of pregnancy are extremely common [1,2] the causal factors are still unknown. An endocrine etiology remains a plausible but unproved theory.…”

Section: Introductionmentioning

confidence: 99%

Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

Järnfelt-Samsioe¹,

Eriksson²,

Waldenström³

et al. 1986

Gynecol Obstet Invest

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The etiology of nausea and vomiting in pregnancy is still unknown. One possibility is that ovarian and placental hormones may play some part. The liver is the major site of metabolic inactivation of steroid hormones. In this study, 102 healthy pregnant women, of whom 62 complained of nausea, were followed throughout pregnancy. Liver function tests were performed to ascertain whether emesis gravidarum is related to impaired hepatic function. In this series, all values were within the normal ranges. Serum levels of total bilirubin and gamma-glutamyl-transferase were significantly decreased and those of total serum bile acids significantly increased in emetic women compared to nonemetic subjects. Furthermore, the metabolic load on the liver seems to follow a biphasic course as there is an apparent minimum in liver function variables in the second trimester. It is concluded that a slow adaptation to the increased hormonal load on the liver might be responsible for the condition of emesis gravidarum.

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Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities

Czeizel¹,

Puhó²,

Ács³

et al. 2006

American J of Med Genetics Pt A

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The objective of the study was to investigate the possible association between nausea and vomiting in early pregnancy and congenital abnormalities. The prevalence of medically-recorded severe nausea and vomiting in early pregnancy in cases with congenital abnormalities and their available matched population controls without any defect was compared in the population-based large data set of the Hungarian Case-Control Surveillance System of congenital abnormalities, 1980-1996. Of 22,843 cases with as 25 different congenital abnormality groups, 1,713 (7.5%) cases had mothers with medically recorded and treated severe nausea and vomiting during pregnancy. Of 38,151 matched population controls, 3,777 (9.9%) had mothers with severe nausea and vomiting (adjusted prevalence odds ratio (POR) with 95% CI: 0.74, 0.68-0.79). Five congenital abnormality groups: cleft lip with or without cleft palate (0.50, 0.37-0.70), posterior cleft palate (0.53, 0.32-0.89), renal a/dysgenesis (0.23, 0.06-0.96), obstructive defects of urinary tract (0.32, 0.18-0.58), and cardiovascular malformations (0.68, 0.57-0.81) had mothers with a lower prevalence of severe nausea and vomiting in pregnancy (adjusted PORs with 95% CI included in parentheses). Of 25 congenital abnormality groups, 22 had POR lower than 1. Thus in this study the mothers of cases with congenital abnormalities were 26% less likely to have had severe nausea and vomiting in early pregnancy than the mothers of population controls without congenital abnormalities.

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Nausea and Vomiting in Pregnancy—A Contribution to Its Epidemiology

Cited by 17 publications

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Pregnancy Nausea Related to Women’s Obstetric and Personal Histories

Pregnancy Nausea Related to Women’s Obstetric and Personal Histories

Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities

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Nausea and Vomiting in Pregnancy—A Contribution to Its Epidemiology

Cited by 17 publications

References 0 publications

Pregnancy Nausea Related to Women&rsquo;s Obstetric and Personal Histories

Pregnancy Nausea Related to Women&rsquo;s Obstetric and Personal Histories

Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities

Contact Info

Product

Resources

About

Pregnancy Nausea Related to Women’s Obstetric and Personal Histories

Pregnancy Nausea Related to Women’s Obstetric and Personal Histories