Nephroprotective and antioxidant properties of Artemisia arborescens hydroalcoholic extract against oestroprogestative-induced kidney damages in rats

Dhibi, Sabah; Bouzenna, Hafsia; Samout, Noura; Tlili, Zied; Elfeki, Abdelfettah; Hfaïedh, Najla

doi:10.1016/j.biopha.2016.05.020

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…The antioxidant properties of polyphenols were also involved in the nephroprotective activity of some vegetable extracts from the Asteraceae family, such as Cynara scolimus L., Matricaria chamomilla L., Artemisia arborescens L. etc. [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Epure

Pârvu

Vlase

et al. 2020

Plants

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The present study analyzed the methanol extract and tincture obtained from the spontaneous Romanian Cichorium intybus species, in order to evaluate polyphenols content and some biological properties. Chromatographic and spectrophotometric methods were used for the analysis of polyphenols and the antioxidant capacity was assessed in vitro with DPPH● (2,2-diphenyl-picrylhydrazil) and FRAP (ferric-reducing antioxidant power) tests. The cardio-protective effects of Cichorii herba tincture on myocardial ischemia induced by isoprenaline and nephroprotection on renal failure induced by gentamicin were evaluated on rats. Also, aspartate aminotrasferase (AST), alanine aminotransferase (ALT), creatine kinase-MB (CK-MB) and creatinine clearance (CrCl) were measured. The antioxidant effect was evaluated by determining total oxidative stress (TOS), oxidative stress index (OSI, total antioxidant capacity (TAC), malondyaldehide (MDA), total thiols (SH) and total nitrites and nitrates (NOx). Cichoric acid was the main polyphenolic compound. The extracts had moderate in vitro antioxidant activity but the in vivo antioxidant and anti-inflammatory effects were significant and associated with myocardial and renal dysfunction improvement. The results were attributed to the content of polyphenols in the extracts, for which reason C. intybus may be considered an important raw material for pharmaceuticals formulations recommended in the prevention or treatment of heart or kidney diseases.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Epure

Pârvu

Vlase

et al. 2020

Plants

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“…Pyrogallol was determined as main component while the minor compound among the scanned compounds was gallic acid. Similarly, phenolic compounds of Artemisia arborescens had been investigated and presence of 7 phenolic acids and 5 flavonoids was reported by Dhibi et al [19]. As we have already mentioned, there are not many findings in the literature about phenolic compounds of Artemisia species.…”

Section: Type Of Inhibitionmentioning

confidence: 84%

“…Both all obtained results and findings in the literature indicate that observed benefits of the extract have been attributed to the presence of several flavonoids and phenolic compounds in it [19]. To explore the phenolic profile of the A. argyi extract, it was analyzed by HPLC and results are summarized in Table 2.…”

Section: Type Of Inhibitionmentioning

confidence: 87%

Phenolic Profile and Cholinesterase, Tyrosinase, Urease and Lipid Peroxidation Inhibition Potentials of Artemisia argyi from Ordu, Turkey

Ayvaz

2019

Celal Bayar Üniversitesi Fen Bilimleri Dergisi

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The present study was designed to reveal a natural resource that could cure for today's major diseases such as Alzheimer, Parkinson and bacterial infection. Furthermore, oxidative stress resulting from lipid peroxidation is a precursor for many diseases. Therefore, anticholinesterase, antityrosinase, antiurease activities and the inhibition potential on lipid peroxidation of methanolic extract of Artemisia argyi collected from Ordu region were tested. The inhibition ratio of extract at 0.3 mg/mL concentration for asetylcholinesterase and butrylcholinesterase were calculated as 8.45 and 10.68%, respectively. IC50 values for tyrosinase and urease inhibition properties were also found as 0.505 mg/mL and 0.225 mg/mL. The all obtained values were compared with known corresponding inhibitors such as galantamine, kojic acid and thiourea. Besides these, 0.1 mg/mL of the extract prevented lipid peroxidation in the ratio of 7.19%. In the scope of this study, the phenolics of the leaves of A. argyi were also analyzed by using HPLC system and pyrogallol was identified as the major component with the 30.16 mg/kg concentration. On the other hand, benzoic acid was not detected in extract. According to obtained results, A. argyi from Ordu, has the proposed characteristics that it can be a natural resource that can be used in the field of medicine for treatment of various diseases especially Alzheimer and Parkinson, in the cosmetic industry for the elimination of skin problems and in the agricultural field in order to prevent the loss of nitrogenous components.

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“…15 Furthermore, the nephroprotective effect of A. absinthium has not been previously studied, and the greater effect of methanolic extract has been demonstrated by this study. Although the nephroprotective effect of A. absinthium has not been previously studied, the effect of other Artemisia species has been studied, showing the effect of Artemisia arborescens 30 , Artemisia herba-alba 31 , Artemisia sieberi 12 , Artemisia campestris L. 32 and Artemisia scoparia 33 , being similar to the one presented by A. absinthium. At the histopathological level, the methanolic extract of A. absinthium showed a substantial decrease in tubular and glomerular damage, becoming physiologically almost normal.…”

Section: Discussionmentioning

confidence: 97%

Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats

Sagástegui-Guarniz¹,

Silva-Correa²,

Torre³

et al. 2020

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Background: Artemisia absinthium L. is known for its antimalarial activity however, hepatoprotective activity of aqueous extracts has also been reported but, nephroprotective activity not yet evaluated. Objective: To evaluate the hepatoprotective and nephroprotective activities of A. absinthium against diclofenac-induced toxicity on rats. Materials and Methods: Three different doses of methanol and ethyl acetate extract of A. absinthium (50, 100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Rats received these doses for 5 days and on the 3rd and 4th day diclofenac (50 mg/kg i.p.) was administered 1 h after treatment. Animals were sacrificed 48 h after the last injection of diclofenac. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. Results: A. absinthium reduced the elevated blood levels of ALT, AST, ALP, urea and creatinine with the methanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that A. absinthium decreased hepatic and renal necrosis induced by diclofenac. Conclusions: Hepatoprotective and nephroprotective activities of methanol and ethyl acetate extract of A. absinthium were demonstrated, being methanol extract to 200 mg/kg/day the most effective. This provides scientific support for the use of medicinal plants such as A. absinthium in the treatment of liver and kidney disorders.

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Nephroprotective and antioxidant properties of Artemisia arborescens hydroalcoholic extract against oestroprogestative-induced kidney damages in rats

Cited by 17 publications

References 29 publications

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Phenolic Profile and Cholinesterase, Tyrosinase, Urease and Lipid Peroxidation Inhibition Potentials of Artemisia argyi from Ordu, Turkey

Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats

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