Neural Correlates of Auditory Verbal Hallucinations in Schizophrenia and the Therapeutic Response to Theta-Burst Transcranial Magnetic Stimulation

Chen, Xingui; Ji, Gong‐Jun; Zhu, Chunyan; Bai, Xiaomeng; Wang, Lu; He, Kai; Gao, Yang; Liu, Tao; Yu, Fang; Tian, Yanghua; Wang, Kai

doi:10.1093/schbul/sby054

Cited by 59 publications

(52 citation statements)

References 62 publications

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“…This hope was also preliminarily bolstered by our recent works (He et al 2018;Yang et al 2018), in which the music intervention (listening to Mozart music), as a type of the auditory input, improved the functional integration in VAN and SSs in schizophrenia. In addition, considering numerous studies have shown that noninvasive neuromodulation technique, for example, repetitive transcranial magnetic Downloaded from https://academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhy232/5112936 by University of Electronic Science and Technology of China user on 18 December 2018 stimulation (rTMS) can produce promising clinical effects in patients with schizophrenia, especially for negative symptoms and auditory hallucinations (Lefaucheur et al 2014;Chen et al 2018), it is worth for future study to explore whether combing sensory-based and rTMS treatment would produce more significant clinical effects than conducting each modality separately.…”

Section: Discussionmentioning

confidence: 99%

Reconfiguration of Dynamic Functional Connectivity in Sensory and Perceptual System in Schizophrenia

et al. 2018

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Schizophrenia is thought as a self-disorder with dysfunctional brain connectivity. This self-disorder is often attributed to high-order cognitive impairment. Yet due to the frequent report of sensorial and perceptual deficits, it has been hypothesized that self-disorder in schizophrenia is dysfunctional communication between sensory and cognitive processes. To further verify this assumption, the present study comprehensively examined dynamic reconfigurations of resting-state functional connectivity (rsFC) in schizophrenia at voxel level, region level, and network levels (102 patients vs. 124 controls). We found patients who show consistently increased rsFC variability in sensory and perceptual system, including visual network, sensorimotor network, attention network, and thalamus at all the three levels. However, decreased variability in high-order networks, such as default mode network and frontal–parietal network were only consistently observed at region and network levels. Taken together, these findings highlighted the rudimentary role of elevated instability of information communication in sensory and perceptual system and attenuated whole-brain integration of high-order network in schizophrenia, which provided novel neural evidence to support the hypothesis of disrupted perceptual and cognitive function in schizophrenia. The foci of effects also highlighted that targeting perceptual deficits can be regarded as the key to enhance our understanding of pathophysiology in schizophrenia and promote new treatment intervention.

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Section: Discussionmentioning

confidence: 99%

Reconfiguration of Dynamic Functional Connectivity in Sensory and Perceptual System in Schizophrenia

et al. 2018

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“…This study aimed to investigate possible imaging correlates of common/specific trans-diagnostic abnormalities. Recently, the neurobiological alterations in SCH and DEP has been investigated using MRI and (EEG) [3][4][5][6][7][8][9] . Volumetric reductions in the gray matter of the prefrontal cortex were consistently reported in SCH 10 .…”

Section: Introductionmentioning

confidence: 99%

Aberrant Prefrontal–Thalamic–Cerebellar Circuit in Schizophrenia and Depression: Evidence From a Possible Causal Connectivity

Jiang

Duan

Chen

et al. 2019

Int. J. Neur. Syst.

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Neuroimaging studies have suggested the presence of abnormalities in the prefrontal-thalamic-cerebellar circuit in schizophrenia (SCH) and depression (DEP). However, the common and distinct structural and causal connectivity abnormalities in this circuit between the two disorders are still unclear. In the current study, structural and resting-state functional magnetic resonance imaging (fMRI) data were acquired from 20 patients with SCH, 20 depressive patients and 20 healthy controls (HC). Voxel-based morphometry analysis was first used to assess gray matter volume (GMV). Granger causality analysis, seeded at regions with altered GMVs, was subsequently conducted. To discover the differences between the groups, ANCOVA and post hoc tests were performed. Then, the relationships between the structural changes, causal connectivity and clinical variables were investigated. Finally, a leave-one-out resampling method was implemented to test the consistency. Statistical analyses showed the GMV and causal connectivity changes in the prefrontal-thalamic-cerebellar circuit. Compared with HC, both SCH and DEP exhibited decreased GMV in middle frontal gyrus (MFG), and a lower GMV in MFG and medial prefrontal cortex (MPFC) in SCH than DEP. Compared with HC, both patient groups showed increased causal flow from the right cerebellum to the MPFC (common causal connectivity abnormalities). And distinct causal connectivity abnormalities (increased causal connectivity from the left thalamus to the MPFC in SCH than HC and DEP, and increased causal connectivity from the right cerebellum to the left thalamus in DEP than HC and SCH). In addition, the structural deficits in the MPFC and its causal connectivity from the cerebellum were associated with the negative symptom severity in SCH. This study found common/distinct structural deficits and aberrant causal connectivity patterns in the prefrontal-thalamic-cerebellar circuit in SCH and DEP, which may provide a potential direction for understanding the convergent and divergent psychiatric pathological mechanisms between SCH and DEP. Furthermore, concomitant structural and causal connectivity deficits in the MPFC may jointly contribute to the negative symptoms of SCH.

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“…The cTBS protocol lasted 40 s and consisted of a burst of three pulses delivered at 50 Hz, which was repeated every 200 ms (at 5 Hz) for a total of 600 pulses. This 40-s protocol was repeated three times (1800 pulses in total) with two 15-min breaks (controlled by a stopwatch) (Nettekoven et al, 2014;Ji et al, 2017;Chen et al, 2018). cTBS was performed in a triple way to achieve accumulative aftereffects (Nettekoven et al, 2014).…”

Section: Landerosmentioning

confidence: 99%

“…Functional MRI studies for TMS could be roughly categorized into three classes that focused on immediate (Chen et al, 2013), short-term (Ji et al, 2017), and long-term (Chen et al, 2018) after-effects, respectively. Interleaved TMS and fMRI acquisition could reveal the immediate after-effect seconds after stimulations.…”

Section: Group-level After-effectsmentioning

confidence: 99%

Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response

Sun

et al. 2020

Front. Neurosci.

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To understand the neural mechanism of repetitive transcranial magnetic stimulation (rTMS), the after-effects following one session or multiple days of stimulation have been widely investigated. However, the relation between the short-term effect (STE) and long-term effect (LTE) of rTMS is largely unknown. This study aims to explore whether the after-effects of 5-day rTMS on supplementary motor area (SMA) network could be predicted by one-session response. A primary cohort of 38 healthy participants underwent five daily sessions of real or sham continuous theta-burst stimulation (cTBS) on the left SMA. Resting-state functional magnetic resonance imaging (fMRI) data were acquired at the first (before and after the first stimulation) and sixth experimental day. The SMA connectivity changes after the first cTBS and after 5 days of stimulation were defined as STE and LTE, respectively. Compared to the baseline, significant STE and LTE were found in the bilateral paracentral gyrus (ParaCG) after real stimulation, suggesting shared neural correlates of short-and long-term stimulations. Region-ofinterest analysis indicated that the resting-state functional connectivity between SMA and ParaCG increased after real stimulation, while no significant change was found after sham stimulation. Leave-one-out cross-validation indicated that the LTE in ParaCG could be predicted by the STE after real but not sham stimulations. In an independent cohort, the after-effects of rTMS on ParaCG and short-to long-term prediction were reproduced at the region-of-interest level. These imaging evidences indicate that onesession rTMS can aid to predict the regions responsive to long-term stimulation and the individualized response degree.

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Neural Correlates of Auditory Verbal Hallucinations in Schizophrenia and the Therapeutic Response to Theta-Burst Transcranial Magnetic Stimulation

Cited by 59 publications

References 62 publications

Reconfiguration of Dynamic Functional Connectivity in Sensory and Perceptual System in Schizophrenia

Reconfiguration of Dynamic Functional Connectivity in Sensory and Perceptual System in Schizophrenia

Aberrant Prefrontal–Thalamic–Cerebellar Circuit in Schizophrenia and Depression: Evidence From a Possible Causal Connectivity

Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response

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