Neurons with histaminelike immunoreactivity in the segmental and stomatogastric nervous systems of the crayfishPacifastacus leniusculus and the lobsterHomarus americanus

Mulloney, Brian; Hall, Wendy M.

doi:10.1007/bf00678725

Cited by 53 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, our data indicate that activity of the modulatory PS neurons in the American lobster, H. americanus, modulates the oesophageal rhythm in the CoGs by differentially utilizing histamine (Mulloney and Hall, 1991), but not Crust-MS, the PS neuron cotransmitter we identified in the present study through RT-PCR analysis. Our results, coupled with the documentation of PS neuron synaptic connectivity in the CoGs (Cazalets et al, 1990b;Meyrand et al, 1994), suggest that this modulation occurs directly within the CoGs.…”

Section: Discussionsupporting

confidence: 56%

“…Thus, for the rest of this paper, Crust-MS effects refer to the effects of short-term bath application of Crust-MS. The PS neurons contain Crust-MS, but histamine is also present, as shown previously (Mulloney and Hall, 1991;Le Feuvre et al, 2001). We therefore examined the effects of a 3ms focal application of histamine to the STG and compared it with the modulation produced by Crust-MS application.…”

Section: Ps Stimulation Crust-ms Application and Focal Histamine Appmentioning

confidence: 80%

“…The pyloric suppressor (PS) neurons of homarid lobsters contain at least two co-transmitters: histamine (Mulloney and Hall, 1991;Le Feuvre et al, 2001) and an FMRFamide-like peptide (Fénelon et al, 1998). Their morphology is well characterized, with terminal endings in all four ganglia of the STNS [the oesophageal ganglion (OG), paired commissural ganglia (CoGs) and stomatogastric ganglion (STG)] (Meyrand et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia

Kwiatkowski

Gabranski

Huber

et al. 2013

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARYWhile many neurons are known to contain multiple neurotransmitters, the specific roles played by each co-transmitter within a neuron are often poorly understood. Here, we investigated the roles of the co-transmitters of the pyloric suppressor (PS) neurons, which are located in the stomatogastric nervous system (STNS) of the lobster Homarus americanus. The PS neurons are known to contain histamine; using RT-PCR, we identified a second co-transmitter as the FMRFamide-like peptide crustacean myosuppressin (Crust-MS). The modulatory effects of Crust-MS application on the gastric mill and pyloric patterns, generated in the stomatogastric ganglion (STG), closely resembled those recorded following extracellular PS neuron stimulation. To determine whether histamine plays a role in mediating the effects of the PS neurons in the STG, we bath-applied histamine receptor antagonists to the ganglion. In the presence of the antagonists, the histamine response was blocked, but Crust-MS application and PS stimulation continued to modulate the gastric and pyloric patterns, suggesting that PS effects in the STG are mediated largely by Crust-MS. PS neuron stimulation also excited the oesophageal rhythm, produced in the commissural ganglia (CoGs) of the STNS. Application of histamine, but not Crust-MS, to the CoGs mimicked this effect. Histamine receptor antagonists blocked the ability of both histamine and PS stimulation to excite the oesophageal rhythm, providing strong evidence that the PS neurons use histamine in the CoGs to exert their effects. Overall, our data suggest that the PS neurons differentially utilize their cotransmitters in spatially distinct locations to coordinate the activity of three independent networks.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Ps Stimulation Crust-ms Application and Focal Histamine Appmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia

Kwiatkowski

Gabranski

Huber

et al. 2013

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…Weimann et al (1993) demonstrated that the major native FMRFamide-like molecules in C. borealis are extended FLRFamide peptides (SDRN FLRFamide and TN RN FLRFamide). To detect histamine-like immunoreactivity, a rabbit polyclonal antibody generated against histamine (Accurate Chemicals) (Mulloney and Hall, 1991) was used. This antibody required the use of an EDAC fixative (see above) and was used at 1:500 (Christie, 1995).…”

Section: Abstract: Stomatogastric Nervous System; Crustacea; Projectmentioning

confidence: 99%

Different Proctolin Neurons Elicit Distinct Motor Patterns from a Multifunctional Neuronal Network

et al. 1999

View full text Add to dashboard Cite

Distinct motor patterns are selected from a multifunctional neuronal network by activation of different modulatory projection neurons. Subsets of these projection neurons can contain the same neuromodulator(s), yet little is known about the relative influence of such neurons on network activity. We have addressed this issue in the stomatogastric nervous system of the crab Cancer borealis. Within this system, there is a neuronal network in the stomatogastric ganglion (STG) that produces many versions of the pyloric and gastric mill rhythms. These different rhythms result from activation of different projection neurons that innervate the STG from neighboring ganglia and modulate STG network activity. Three pairs of these projection neurons contain the neuropeptide proctolin. These include the previously identified modulatory proctolin neuron and modulatory commissural neuron 1 (MCN1) and the newly identified modulatory commissural neuron 7 (MCN7). We document here that each of these neurons contains a unique complement of cotransmitters and that each of these neurons elicits a distinct version of the pyloric motor pattern. Moreover, only one of them (MCN1) also elicits a gastric mill rhythm. The MCN7-elicited pyloric rhythm includes a pivotal switch by one STG network neuron from playing a minor to a major role in motor pattern generation. Therefore, modulatory neurons that share a peptide transmitter can elicit distinct motor patterns from a common target network.

show abstract

“…Therefore we focused our attention on the three groups of projection neurons (GPR, GN1/2, PS) that have been shown to express FLRFamide immunoreactivity. Moreover, these neurons also express cotransmitters in the adult, such as serotonin for the GPR cells and GABA for GN1/2 neurons (Cournil et al, 1990;Meyrand et al, 2000), and in other species PS neuron homologs display histamine immunoreactivity (Mulloney and Hall, 1991). Previous indirect studies suggest that, for example, the GPR neurons gradually acquire their neurotransmitter (FLRFamide, allatostatin, and serotonin) phenotype during development .…”

Section: Comparison Of Neurotransmitter Phenotype Of Embryonic and Admentioning

confidence: 99%

Ontogeny of Modulatory Inputs to Motor Networks: Early Established Projection and Progressive Neurotransmitter Acquisition

2001

View full text Add to dashboard Cite

Modulatory information plays a key role in the expression and the ontogeny of motor networks. Many developmental studies suggest that the acquisition of adult properties by immature networks involves their progressive innervation by modulatory input neurons. Using the stomatogastric nervous system of the European lobster Homarus gammarus, we show that contrary to this assumption, the known population of projection neurons to motor networks, as revealed by retrograde dye migration, is established early in embryonic development. Moreover, these neurons display a large heterogeneity in the chronology of acquisition of their full adult neurotransmitter phenotype.We performed retrograde dye migration to compare the neuronal population projecting to motor networks located in the stomatogastric ganglion in the embryo and adult. We show that this neuronal population is quantitatively established at developmental stage 65%, and each identified projection neuron displays the same axon projection pattern in the adult and the embryo. We then combined retrograde dye migration with FLRFamide-like, histamine, and GABA immunocytochemistry to characterize the chronology of neurotransmitter expression in individual identified projection neurons. We show that this early established population of projection neurons gradually acquires its neurotransmitter phenotype complement. This study indicates that (1) the basic architecture of the known population of projection inputs to a target network is established early in development and (2) ontogenetic plasticity may depend on changes in neurotransmitter phenotype expression within preexisting neurons rather than in the addition of new projection neurons or fibers.

show abstract

Neurons with histaminelike immunoreactivity in the segmental and stomatogastric nervous systems of the crayfishPacifastacus leniusculus and the lobsterHomarus americanus

Cited by 53 publications

References 22 publications

Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia

Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia

Different Proctolin Neurons Elicit Distinct Motor Patterns from a Multifunctional Neuronal Network

Ontogeny of Modulatory Inputs to Motor Networks: Early Established Projection and Progressive Neurotransmitter Acquisition

Contact Info

Product

Resources

About