Neuropsychiatry of creativity

Mula, Marco; Hermann, Bruce P.; Trimble, Michael

doi:10.1016/j.yebeh.2015.12.050

Cited by 11 publications

(12 citation statements)

References 36 publications

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“…Accumulated evidence suggests a strong connection between developing the drive of creativity and a number of brain illnesses (i.e., depression, bipolar disorder, psychosis, PD, temporal lobe epilepsy (TLE), frontotemporal dementia (FTD), and autism spectrum disorders (ASDs); see Flaherty, 2011, see also Flaherty, 2005; Carson, 2011; Abraham et al, 2012; Mula et al, 2016), other studies questioned the relation between madness and genius (Kyaga, 2014).…”

Section: Brain Illness and Creativitymentioning

confidence: 99%

The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms

Khalil

Godde

Karim

2019

Front. Neural Circuits

103

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Having a creative mind is one of the gateways for achieving fabulous success and remarkable progress in professional, personal and social life. Therefore, a better understanding of the neural correlates and the underlying neural mechanisms related to creative ideation is crucial and valuable. However, the current literature on neural systems and circuits underlying creative cognition, and on how creative drives such as motivation, mood states, and reward could shape our creative mind through the associated neuromodulatory systems [i.e., the dopaminergic (DA), the noradrenergic (NE) and the serotonergic (5-HT) system] seems to be insufficient to explain the creative ideation and production process. One reason might be that the mentioned systems and processes are usually investigated in isolation and independent of each other. Through this review, we aim at advancing the current state of knowledge by providing an integrative view on the interactions between neural systems underlying the creative cognition and the creative drive and associated neuromodulatory systems (see Figure 1 ).

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Section: Brain Illness and Creativitymentioning

confidence: 99%

The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms

Khalil

Godde

Karim

2019

Front. Neural Circuits

103

View full text Add to dashboard Cite

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“…A potential link between creativity and psychopathology and, more recently, bipolar disorders has also been discussed throughout cultural history [11] and is supported by the findings of modern neurobiological research [12] . Doerr-Zegers [13] and Doerr-Zegers et al [14] have addressed the relationship between genius and melancholy with phenomenological analyses of the creative struggles of Sören Kierkegaard, Alexander von Humboldt, and Rainer Maria Rilke.…”

Section: Introductionmentioning

confidence: 81%

Bipolar Disorder and/or Creative Bipolarity: Robert Schumann's Exemplary Psychopathology - Combining Symptomatological and Psychosocial Perspectives with Creativity Research

Holm‐Hadulla

Koutsoukou-Argyraki

2017

Psychopathology

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The psychopathological condition of Robert Schumann has been a prominent object of study in psychiatry since his hospitalization in 1854. Renowned psychiatrists have diagnosed Schumann with syphilis, schizophrenia, and bipolar and personality disorders. Until today, these analyses of his symptomatology have led to contradictory results. Recent discussion has suggested that his hospitalization was due to professional failure and separation wishes on the part of his wife, her family, and her friends. In line with this hypothesis is the opinion that the separation insisted upon by Clara Schumann was reinforced by the economic interests of the psychiatrist who kept Schumann in custody for 2 years until his death in 1856. In this article, we trace the complex interaction of bipolar vulnerability and pathogenic life events with hypersensitive talent and “creative bipolarity,” defined as the capacity, motivation, and resilience to transform emotional stress and cognitive inconsistency into coherent artistic products. Finally, we present our conclusions about comprehensive psychiatric and psychotherapeutic treatment with respect to “creative bipolarity.”

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“…Though there is no correlation between epilepsy and enhanced creativity in music and poetry, the impaired creativity due to epilepsy or epilepsy treatment provides an opportunity to better understand human creativity as a function of intact and properly functioning cerebral circuitry. 28 , 29 , 45 Impairment of the creative process in epileptics is thought to be a result of the impaired neural circuitry. 28 , 45 …”

Section: Epilepsy In History and Literaturementioning

confidence: 99%

“… 28 , 29 , 45 Impairment of the creative process in epileptics is thought to be a result of the impaired neural circuitry. 28 , 45 …”

Section: Epilepsy In History and Literaturementioning

confidence: 99%

Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms

Rao

Mashkouri

Aum

et al. 2017

NDT

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Epilepsy is a debilitating disease that impacts millions of people worldwide. While unprovoked seizures characterize its cardinal symptom, an important aspect of epilepsy that remains to be addressed is the neuropsychiatric component. It has been documented for millennia in paintings and literature that those with epilepsy can suffer from bouts of aggression, depression, and other psychiatric ailments. Current treatments for epilepsy include the use of antiepileptic drugs and surgical resection. Antiepileptic drugs reduce the overall firing of the brain to mitigate the rate of seizure occurrence. Surgery aims to remove a portion of the brain that is suspected to be the source of aberrant firing that leads to seizures. Both options treat the seizure-generating neurological aspect of epilepsy, but fail to directly address the neuropsychiatric components. A promising new treatment for epilepsy is the use of stem cells to treat both the biological and psychiatric components. Stem cell therapy has been shown efficacious in treating experimental models of neurological disorders, including Parkinson’s disease, and neuropsychiatric diseases, such as depression. Additional research is necessary to see if stem cells can treat both neurological and neuropsychiatric aspects of epilepsy. Currently, there is no animal model that recapitulates all the clinical hallmarks of epilepsy. This could be due to difficulty in characterizing the neuropsychiatric component of the disease. In advancing stem cell therapy for treating epilepsy, experimental testing of the safety and efficacy of allogeneic and autologous transplantation will require the optimization of cell dosage, delivery, and timing of transplantation in a clinically relevant model of epilepsy with both neurological and neuropsychiatric symptoms of the disease as the primary outcome measures.

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Neuropsychiatry of creativity

Cited by 11 publications

References 36 publications

The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms

The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms

Bipolar Disorder and/or Creative Bipolarity: Robert Schumann's Exemplary Psychopathology - Combining Symptomatological and Psychosocial Perspectives with Creativity Research

Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms

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