“…These thioether compounds retain the ability to redox cycle and are toxic to 5-HT neurons. In fact, they are more toxic than MDMA itself (Monks et al, 2004;Ferreira et al, 2013) and have also been detected in vivo after MDMA exposure (de la Torre and Farre, 2004;Perfetti et al, 2009). Nonetheless, DA remains an important factor also in MDMA-induced 5-HT toxicity (Stone et al, 1988;Schmidt et al, 1990;Shankaran et al, 1999;Falk et al, 2002;Breier et al, 2006).…”