New Monoterpenoid Coumarins from Clausena anisum-olens

Wang, Yunsong; He, Hong-Pin; Yang, Jing‐Hua; Di, Ying‐Tong; Hao, Xiao‐Jiang

doi:10.3390/molecules13040931

Cited by 33 publications

(15 citation statements)

References 14 publications

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“…Duarte et al (2007) and Wang et al (2008) classified the extracts as: strong inhibitors for MIC value below 500 mg/mL; moderate inhibitors for MIC between 600 and 1500 mg/mL; weak inhibitors for MIC above 1600 mg/mL. This classification is very useful in detecting the potential biological activity of various plant materials.…”

Section: Discussionmentioning

confidence: 97%

Antimicrobial activities of various fractions of longan (Dimocarpus longan Lour.Fen Ke) seed extract

Tseng

Huang

et al. 2014

International Journal of Food Sciences and Nutrition

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The antimicrobial activities of longan (Dimocarpus longan Lour. Fen ke) seed extracts were investigated using a disc diffusion method and also determining the minimal inhibitory concentration. The DL-P01-SI01 fraction showed that the strongest activity against Staphylococcus aureus and methicillin-resistant S. aureus at MIC 64 μg/mL, which was found to be due to the phenolic compounds. The HPLC analysis showed that the major phenolic compounds are gallic acid, corilagin, ethyl gallate and ellagic acid.

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Section: Discussionmentioning

confidence: 97%

Antimicrobial activities of various fractions of longan (Dimocarpus longan Lour.Fen Ke) seed extract

Tseng

Huang

et al. 2014

International Journal of Food Sciences and Nutrition

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“…The minimum inhibitory concentration for the two extracts was tested on two microorganisms, as presented in Table 4. Duarte et al (2007) and Wang et al (2008) classified the extracts as strong inhibitors for MIC values below 500 lg/mL, moderate inhibitors for MIC between 600 and 1500 lg/mL and weak inhibitors for MIC above 1600 lg/mL. Thus, the two extracts obtained in this work may be considered weak inhibitors for Staphylococcus aureus with the minimum inhibitory concentration found of 2000 lg/mL.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical profile, antioxidant and antimicrobial activity of extracts obtained from erva-mate (Ilex paraguariensis) fruit using compressed propane and supercritical CO2

et al. 2016

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Traditionally, Ilex paraguariensis leaves are consumed in tea form or as typical drinks like mate and terere, while the fruits are discarded processing and has no commercial value. The aim of this work to evaluate phytochemical properties, total phenolic compounds, antioxidant and antimicrobial activity of extracts of Ilex paraguariensis fruits obtained from supercritical CO 2 and compressed propane extraction. The extraction with compressed propane yielded 2.72 wt%, whereas with supercritical CO 2 1.51 wt% was obtained. The compound extracted in larger amount by the two extraction solvents was caffeine, 163.28 and 54.17 mg/g by supercritical CO 2 and pressurized propane, respectively. The antioxidant activity was more pronounced for the supercritical CO 2 extract, with no difference found in terms of minimum inhibitory concentration for Staphylococcus aureus for the two extracts and better results observed for Escherichia coli when using supercritical CO 2 .

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“…At present, there is no undisputed evaluation agreement about the antibacterial activity of plant-derived materials -according to the previous standards based on MIC values, the antibacterial activity of plant-derived extracts and compounds could be classified as (i) strong inhibitors, with an MIC lower than 500 g/mL; (ii) moderate inhibitors, with an MIC between 600 and 1500 g/mL; (iii) weak inhibitors, with an MIC higher than 1600 g/mL (Wang et al 2008;Michielin et al 2009). Herein, our results showed that ET-RPC possessed significant antibacterial activities against all of the tested MRSA strains in a dose-dependent manner, providing a good indication for further investigation.…”

Section: Discussionmentioning

confidence: 99%

Emodin is identified as the active component of ether extracts from Rhizoma Polygoni Cuspidati, for anti-MRSA activity

Chen

Peng

et al. 2015

Can. J. Physiol. Pharmacol.

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This study investigated the anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity and chemical compositions of ether extracts from Rhizoma Polygoni Cuspidati (ET-RPC). Significant anti-MRSA activities of ET-RPC against MRSA252 and MRSA clinical strains were tested in in vitro antibacterial experiments, such as inhibition zone diameter test, minimal inhibitory concentration test, and dynamic bacterial growth assay. Subsequently, 7 major compounds of ET-RPC were purified and identified as polydatin, resveratrol-4-O-d-(6'-galloyl)-glucopyranoside, resveratrol, torachryson-8-O-glucoside, emodin-8-O-glucoside, 6-hydroxy-emodin, and emodin using liquid chromatography - electrospray ionization - tandem mass spectrometry. After investigation of anti-MRSA activities of the 7 major compounds, only emodin had significant anti-MRSA activity. Further, transmission electron microscopy was used to observe morphological changes in the cell wall of MRSA252, and the result revealed that emodin could damage the integrity of cell wall, leading to loss of intracellular components. In summary, our results showed ET-RPC could significantly inhibit bacterial growth of MRSA strains. Emodin was identified as the major compound with anti-MRSA activity; this activity was related to destruction of the integrity of the cell wall and cell membrane.

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New Monoterpenoid Coumarins from Clausena anisum-olens

Abstract: Two new monoterpenoid coumarins: anisucumarin A (1) and B (2), a pair of epimers, were isolated from Clausena anisum-olens. Their structures were established based on extensive spectroscopic analyses.

Cited by 33 publications

References 14 publications

Antimicrobial activities of various fractions of longan (Dimocarpus longan Lour.Fen Ke) seed extract

Antimicrobial activities of various fractions of longan (Dimocarpus longan Lour.Fen Ke) seed extract

Phytochemical profile, antioxidant and antimicrobial activity of extracts obtained from erva-mate (Ilex paraguariensis) fruit using compressed propane and supercritical CO2

Emodin is identified as the active component of ether extracts from Rhizoma Polygoni Cuspidati, for anti-MRSA activity

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