New Polymeric Ion Selective Electrode for Determination of Sulfamethoxazole in Pure and Pharmaceutical Samples

Abstract

Sulfamethoxazole ion selective electrodes were constructed based on sulfamethoxazoletengestophosphoric acid as ion pair complex in a polyvinylchloride matrix and plasticized by four plasticizers, Di-octyl phthalate (DOPH); Tri-butyl phosphate (TBP); Acetophenone (AP) and Nitrobenzene (NB). Sulfamethoxazole electrodes (E1, E2, E3 and E4) gave slopes (52.008, 58.381, 56.909 and 50.309 mV/decade) and linear ranges from (1×10 -5 -1×10 -2 ,1×10 -7 -1×10 -2 ,1×10 -5 -1×10 -2 and 1×10 -5 -1×10 -2 M) respectively. The best electrode (E2) was based on TBP plasticizer which gave a slope 58.381mV/decade, correlation coefficient 0.9997, detection limit of 9×10 -8 M, lifetime 27 day. pH and life time of the electrodes were also studied and the proposed electrode displayed a good stability and reproducibility and were used to determine the Sulfamethoxazole in pharmaceutical samples. The interferences measurements in the presence of (Na + , K + , Cu +2 , Mn +2 , Fe +3 , Al +3 , trimethoprim, starch, sucrose and gelatin) were studied using the separated method and mixed method for selectivity coefficient determination.

Determination of Sulfamethoxazole in Pure and Pharmaceutical Samples by Using Direct Method for Calibration Curve of Normal Spectrum of UV-Spectrophotometry

“…Table 3 shows the comparison between the (normal spectrum) and the (direct method) of ISE using the F-test using a 95% confidence level and this table show standard deviation (δ n1 ) for five measurements where F  S12/S22, where S1 ˃ S2 and F Table equal 6.39 and from the calculations it found F Calculate is less than F Table, and thus, there is no difference in precision between the two methods. Sulfamethoxazole potentiometric determination in pharmaceutical preparations and the data obtained for pharmaceutical samples were listed in Table 4 [14]. RSD: Relative standard deviation, RSD***% for n  2, t  12.7, RSD**% for n  3, t  4.3, RSD*% for n  5, t  2.7, Re%:…”

Enhancing Bone Healing with Autogenous Prp And Hyaluronic Acid: An Experimental Study

“…Bone healing assessment was histopathology done by using a grading system to evaluate the healing process of the bone defects. The grading system was previously used by several researchers (Kim et al, 2004;Maeda et al 2007;Abrahem and Al-Soudani, 2012;Elgendy et al, 2013). This grading system was based on the degree of tissue response in relation to inflammation, granulation tissue formation, and the presence of osteoid tissue.…”

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

“…The ion-pair complexes have been used as ionophores for fabrication of PVC membrane based ion-selective electrode. Phosphotungstate, − tetra phenyl borate, , phosphomolybdate, tungstophosphate, tetrakis (4-chlorophenyl) borate, and silicotungstate were used as counterions in the fabrication of PVC based ion-selective membranes. There is no report available for direct potentiometric determination of lansoprazole involving ion-selective electrode.…”