New Uses for Ocular Adhesives

Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration

“…Isobutyl cyanoacrylate tissue adhesive has been used extensively for more than 25 years for the management of corneal ulcerations, offering a simple, noninvasive treatment for corneal ulcers 9,14 . It is usually applied on an outpatient basis, with little or no sedation required, and is well tolerated 10 . In most cases, the BCTA is spontaneously eliminated in several weeks, facilitating healing, with the end result of a small fibrous scar in the majority of cases 12,15,16 .…”

“…9,14 It is usually applied on an outpatient basis, with little or no sedation required, and is well tolerated. 10 In most cases, the BCTA is spontaneously eliminated in several weeks, facilitating healing, with the end result of a small fibrous scar in the majority of cases. 12,15,16 The presence of BCTA on the cornea often causes mild blepharospasm due to foreign body sensation which resolves in 48-72 h. However, its presence also diminishes pain and ciliary spasm associated with ulceration because it covers exposed corneal nerve endings.…”

“…The use of tissue adhesives in treating corneal ulcers was introduced as early as 1962 8–11 . Isobutyl cyanoacrylate (BCTA) is a tissue adhesive which hardens by an anionic/polymerization mechanism initiated by water or other weak bases present in the adherent surfaces.…”

Estudo macroscópico e dinamométrico comparativo de implantes (ímãs recobertos) e de suas técnicas de fixação em órbitas de coelhas

“…Sorteio da ordem dos tipos e dos grupos de pesquisa para cada lote (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). O grupo controle, para cada lote, foi constituí-do da órbita contralateral de cada coelha.…”

“…A dificuldade de sua obtenção pela técnica de crioprecipitação de fibrinogênio originário em banco de sangue também colabora para a sua não utilização. Além do exposto, o cianoacrilato forma uma proteção entre a esclera e a placa, pelo seu efeito na prevenção de aderências (10)(11) , a qual poderá ser removida em caso de necessidade, não acontecendo o mesmo com o adesivo biológico de fibrina.…”