Nicotinamide Treatment of Schizophrenia

McGrath, Sarah; O'Brien, Patrick; Power, Paddy; Shea, John

doi:10.1093/schbul/1.5.74

Cited by 15 publications

(5 citation statements)

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“…Treatment resistance in schizophrenia has been estimated to be around 30% [7], and increasing numbers of patients are being prescribed clozapine; for example, in the Scottish Schizophrenia Outcomes Study [8], 40% of the cohort of 1015 patients was prescribed clozapine. Given the limited efficacy of current antipsychotics, it is likely that increasing numbers of patients may be treated with clozapine.…”

Section: Discussionmentioning

confidence: 99%

Clozapine-induced interstitial nephritis - a rare but important complication: a case report

et al. 2009

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Introduction: Given the limited range of effective drug treatments for patients with schizophrenia, increasing numbers of patients, often termed 'treatment-resistant' are prescribed clozapine. While the induction of neutropenia or agranulocytosis by clozapine is well appreciated, other rare potentially fatal adverse reactions may also occur including acute interstitial nephritis as reported in this case.

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Section: Discussionmentioning

confidence: 99%

Clozapine-induced interstitial nephritis - a rare but important complication: a case report

et al. 2009

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“…Nineteen RCTs on B vitamins added to antipsychotics ( Ananth et al, 1972 , 1973 ; Deutsch et al, 1977 ; Godfrey et al, 1990 ; Hill et al, 2011 ; Joshi, 1982 ; Kline et al, 1967 ; Lerner et al, 2001 , 2002 , 2004 , 2007 ; Levine et al, 2006 ; McGrath et al, 1972 ; Meltzer et al, 1969 ; Miodownik et al, 2006 ; Petrie et al, 1981 ; Ramsay et al, 1970 ; Roffman et al, 2013 ; Sacks et al, 1989 ; Wittenborn et al, 1973 ) and one on B3 without antipsychotics ( Greenbaum 1970 ) were found. B1 showed some positive effect on general psychopathology (when combined with B6 and B12) in one study ( Joshi, 1982 ) and on positive and negative symptoms in another ( Sacks et al, 1989 ).…”

Section: Reviewmentioning

confidence: 99%

Natural Medicines for Psychotic Disorders

Hoenders¹,

Bartels-Velthuis²,

Vollbehr³

et al. 2018

J Nerv Ment Dis

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Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive dyskinesia and akathisia. Results on other compounds were negative or inconclusive. All natural agents, except reserpine, were well tolerated. Most study samples were small, study periods were generally short, and most results need replication. However, there is some evidence for beneficial effects of certain natural medicines.

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“…In one of tírese studies, carried out in Ireland by McGrath et al (1972), during a calendar year every admitted patient who was diagnosed schizophrenic was given three times daily two tablets which contained either 500 mg nicotinamide or an inert substance. As a result it was found that of the 187 patients who took the tablets for a full year, 71.57 % (or 68 patients) of tire placebo group and 65.16% (or 58 patients) of the nicotinamide group recovered or showed much improvement.…”

Section: Clinical Aspectsmentioning

confidence: 99%