Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Essawy,

doi:10.7324/japs.2012.21004

Cited by 23 publications

(25 citation statements)

References 23 publications

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“…This agrees with other previous results [22, 23]. Several studies revealed the benefits of medical plants like olive oil or Nigella sativa ( N. Sativa ) oil on mice, rat and a rabbit model which showed anti-steatotic, anti-inflammatory and antioxidant effect and also delay in the development of liver disease [68–70]. …”

Section: Discussionsupporting

confidence: 91%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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BackgroundLiver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 induced liver damage in male rats.MethodsForty males of a new model of albino rats (Wistar strain) (175–205 g) were divided into four groups. The 1st Group (G1) was the negative control group, the remaining rats were injected with CCl4 (1 ml/kg body weight) with equal amount of olive oil on the 1st and 4th day of every week for 4 weeks. The 2nd group (G2) was the positive control, the 3rd group (G3) and the fourth group (G4) were treated orally with N. sativa oil and olive oils using stomach tube.ResultsThe positive control group showed an increase in hepatic enzymes, total bilirubin, creatinine, uric acid, lipid peroxide total cholesterol, triglyceride, low density lipoprotein, very low density lipoproteins, interleukin-6, and a decrease in antioxidant enzymes, high density lipoprotein cholesterol, a decrease in total protein and albumin an when compared with negative control group. Histology of the CCl4 treated group revealed inflammation and damage of liver cells. Treating the hepatotoxic rats with olive oil and N. sativa oil showed a significant improvement in all biochemical tests compared with the positive CCl4 control group. In addition, the liver tissues of olive oil treated group showed mild improvement in inflammatory infiltration and in N. sativa oil treated group showed normal hepatocytes with no evidence of inflammation.ConclusionThis study revealed that olive oil and N. sativa oil have a protective effect against CCl4-induced hepatotoxicity in male rats. Nigella sativa oil was more effective than olive oil.

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Section: Discussionsupporting

confidence: 91%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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“…Previous studies showed that rise in SGOT, SGPT, ALP, and LPO level is an important factor in the pathogenesis of CCl 4 -induced liver damage [14,15].…”

Section: Discussionmentioning

confidence: 96%

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Saxena

Shahani

Bhatnagar

2017

Asian J Pharm Clin Res

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Objective:To study the effect of Quinoa seed on carbon tetrachloride (CCL 4 )-induced liver toxicity in Swiss albino male mice. Methods:Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl 4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl 4 -treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted. Results:The results showed that the treatment with Quinoa seed powder significantly reduced CCl 4 -induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies. Conclusion:Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl 4 -induced liver damage in Swiss albino male mice.

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“…Free radical-initiated lipid peroxidation plays a role in hepatic fibrogenesis, which affected the cellular permeability of hepatocytes leading to increasing levels of liver enzymes [5]. Therefore, there is a possible role of antioxidants in the prevention and treatment of liver diseases [6].…”

Section: Introductionmentioning

confidence: 99%

“…Hesperidin (3,5,7-trihydroxy flavanone-7-rhamnoglucoside) [8], a flavanone glycoside present abundantly in citrus fruits [9]. This flavonoid has potential therapeutic benefits including, antiviral, antiallergic, antiplatelet, anti-inflammatory and antioxidant activities [10].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Hesperidin on Carbon Tetrachloride Induced Liver Fibrosis in Rats

Abdel-sttar

Khalaf

Abo-Youssef

et al. 2017

Int J Pharm Pharm Sci

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Objective: Exposure to carbon tetrachloride leads to serious liver injury and fibrosis. This study was aimed to evaluate the hepatoprotective effects of hesperidin against carbon tetrachloride (CCl4)-induced liver fibrosis in rats compared with the reference drug silymarin.Methods: Wistar albino rats were divided into five groups, each of eight rats. Animals were allocated into a control group, corn oil group and fibrosis control group. The remaining two groups received in addition to CCl4, silymarin (100 mg/kg/d) as a reference treatment and hesperidin (200 mg/kg/d). At the end of experimental period, the biomarkers of specific fibrosis [hepatic transforming growth factor β1 (TGF-β1) and hydroxyproline (HYP)], liver function [serum alanine transaminase (ALT), aspartate transaminase (AST), albumin and total bilirubin], oxidative stress [hepatic malondialdehyde (MDA), glutathione (GSH) and catalase (CAT)], inflammatory [hepatic myeloperoxidase (MPO), serum tumor necrosis factor alpha (TNF-α)], relative liver weight, lipid profile [total cholesterol, serum triglycerides, high-density lipoprotein cholesterol (HDLCh) and low density lipoprotein cholesterol (LDL-Ch)] were evaluated, supported by liver histopathological study and immunohistochemistry of alpha-smooth muscle actin (α-SMA) in liver sections.Results: Hesperidin significantly decreased hepatic transforming growth factor β1, hydroxyproline, the serum liver function markers of ALT, AST and total bilirubin, the hepatic content of MDA and MPO activity, the serum pro-inflammatory cytokine TNF-α, relative liver weight, and the serum lipid profile markers cholesterol, triglycerides and LDL. On the other hand, Hesperidin significantly increased albumin, the hepatic content of GSH and CAT, and serum lipid profile of LDL. In addition, liver sections obtained from these groups showed marked histopathological and immunohistochemistry of α-SMA improvement. Conclusion:Hesperidin may be promising protective agent against liver fibrosis through improvement of liver function, modulation of the fibrous scar formation, anti-inflammatory and antioxidant potentials.

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Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Cited by 23 publications

References 23 publications

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Ameliorative Effect of Hesperidin on Carbon Tetrachloride Induced Liver Fibrosis in Rats

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