Níveis plasmáticos de interleucina‐10 e óxido nítrico em resposta a duas taxas de fluxo em anestesia com desflurano

Kalaycı, Dilek; Dikmen, Bayazıt; Kaçmaz, Murat; Taspinar, Vildan; Ornek, Dilsen; Turan, Özlem

doi:10.1016/j.bjan.2013.06.009

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…This kit measures NO by Griess method which is a very well recognized technique to assay nitrate/nitrite [10, 11]. The absorbance was read by an ELISA plate reader (Synergy, BioTek®, Winooski, VT, USA) at 540 nm.…”

Section: Patient and Methodsmentioning

confidence: 99%

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Kouti

Sayyah

Mosallanezhad

et al. 2016

Advances in Medicine

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Objectives. Some studies have shown that increased nitric oxide (NO) concentrations may be associated with obsessive-compulsive disorder (OCD). In a few animal researches, enhanced synthesis of NO had reversed the effect of selective serotonin reuptake inhibitors (SSRIs). The present study tries to find the effect of treatment with SSRIs on NO serum levels and its product peroxynitrite. Patients and Methods. Patients diagnosed with OCD who are candidates of receiving SSRIs entered this study. Two blood samples were taken from subjects, prior to drug therapy and after the patients had shown some improvements due to their regimen. Serum NO and peroxynitrite levels were measured and their correlation with SSRI use was assessed. Results. 31 patients completed this study. Mean concentrations of NO and peroxynitrite prior to drug therapy were 28.63 ± 16.9 and 5.73 ± 2.5 μmol/L, respectively. These values were 18.87 ± 7.55 and 2.15 ± 0.94 μmol/L at the second blood test. With p values < 0.05, these differences were considered significant. Conclusion. Patients, who showed improvement of OCD symptoms after a mean duration of SSRI monotherapy of 3.531 ± 0.64 months, had lower values of NO and peroxynitrite in their sera compared to their levels prior to therapy. Such results can be helpful in finding a predictive factor of response to therapy and augmentation therapy with future drugs that target NO synthesis.

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Section: Patient and Methodsmentioning

confidence: 99%

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Kouti

Sayyah

Mosallanezhad

et al. 2016

Advances in Medicine

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“…The concentration of nitric oxide determined by Griess method (Kalayci et al 2014, Larsen et al 2008, the principle of assay based on colorimetry using kit supplied by Cayman, USA and the optical density at 540nm measured by microplate reader BioTek-Synergy, USA. The concentration of the samples was then extrapolated from the standards supplied by manufacturer kits.…”

Section: Estimation Of Nitric Oxide Activitymentioning

confidence: 99%

Silent hyperlipidaemia modulated vascular endothelial markers

Merkhan¹,

Mohammad²,

Fathi³

et al. 2021

PHAR

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The aetiology of ischemic heart diseases is mainly based on atherosclerosis of coronary artery. Inflammation and oxidative reactions are initiating and aggravating the illness resulting in pathological remodelling of vasculaturze at site of injury. Endothelium lining of blood vessels participated in the reaction biochemically through releasing some proteins into circulatory system which further complicate the condition. The aim of this study was to determine early diagnosed hyperlipidaemia-associated changes of the plasma level of some of these endothelial biomolecules. Compared to healthy control, hyperlipidaemic patients have significantly increased arginase, metalloendopeptidase, peroxidase, myeloperoxidase, and peroxynitrite with concomitant reduction in arylesterase and nitric oxide. The present study concluded that hyperlipidaemia play a great role in modulation of certain plasma protein markers which might be directly related to patient pathological condition or could be used as a tool for diagnosis or patient follow up indicating the stage of vasculature remodelling, healing, inflammation or resolution.

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Anesthesia‐Related Carbon Monoxide Exposure

Levy¹

2022

Carbon Monoxide in Drug Discovery

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Níveis plasmáticos de interleucina‐10 e óxido nítrico em resposta a duas taxas de fluxo em anestesia com desflurano

Cited by 7 publications

References 38 publications

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Silent hyperlipidaemia modulated vascular endothelial markers

Anesthesia‐Related Carbon Monoxide Exposure

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