Abstract. Today it is necessary to analyze health and living conditions with the so-called Social and Economic Determinants approach as relevant variables to determine the healthy physical condition behavior of school children. The objective was to estimate the best predictive model of the Social Determinants of Health and of the healthy physical condition of Colombian school children. The present was a socio-sport study, through a quantitative descriptive statistical analysis. A total of 3458 school children aged 10 to 18 from 10 cities in Colombia participated. A survey was applied to establish the Social Determinants of Health and the healthy physical condition was objectively evaluated through the extended version of the ALPHA FITNESS battery. As results, the following were obtained: a higher percentage of 15-year-old men had a healthy physical condition, age, being active, unhealthy habits, leisure activities and body mass index, and socioeconomic level, coexistence and educational level showed a statistically significant association with healthy physical condition. It is concluded that the body mass index (BMI), the permanence of the father, the number of daily meals, being a beneficiary of a school restaurant, the number of hours that he sleeps at night, are the social determinants of health that are associated with the healthy physical condition variable, in turn, the binary logit model has a good predictive capacity (70.1%).