NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human

Abstract

IL-15 may have a role in the development of T cell large granular lymphocyte (T-LGL

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

“…1C). Besides NK cells, discrete subsets of CD4 − CD8 − NK1.1 + T cells also express NKp46 (6,16,17). Consistent with these data, minute percentages of eYPF + αβT and γδT cells were detected in the spleen (Fig.…”

“…NKp46 is found on all mature NK cells regardless of their anatomic localization in both human and mouse. The selective expression of NKp46 on NK cells has two reported exceptions: rare T-cell subsets (6,16,17) and a mucosal population of NKp46 + innate lymphoid cells (ILCs) that express the transcription factor retinoid-related orphan receptor (ROR)-γt and produce IL-22, a key cytokine for the activation and defense of epithelial cells (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

IL-15 as a potential target in leukemia

“…36 Yu et al demonstrated T-LGL leukemias in IL-15 transgenic mice that expressed NKp46; NKp46-expression was the hallmark of a minute population of wild-type NKT cells with higher activity and potency to become leukemic. 48 Taken together, all these studies showed a role of IL-15 receptor and its signaling pathway in the pathogenesis of LGL leukemia and suggest that these may be useful targets in the treatment of patients with T-LGL or NKT leukemia.…”

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

“…Flow cytometric analysis of liver immune cells was performed as described previously (51). The following antibodies reactive with murine cells were obtained from BD: Gr-1 (RB6-8c5), CD11b (M1/70), CD3 (145-2C11), CD19 (1D3), NK1.1 (PK136), IL-6 (MP5-20F3), and TNF-α (MP6-XT22).…”