Nonallograft Osteoconductive Bone Graft Substitutes

Bucholz, Robert W.

doi:10.1097/00003086-200202000-00006

Cited by 321 publications

(231 citation statements)

References 17 publications

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“…Combined with local bone graft and/or bone marrow aspirate (BMA) from vertebral bodies or the iliac crest the resulting composite features osteoinductive and osteogenic potential as it contains relevant growth factors as well as osteoprogenitor cells [5,7,16,19,28,32,35,36]. The application of these materials as a graft extender in PSF has been reported to be favorable, however, most study results are preliminary [8,9,11,15,22,29,31,33,34,38].…”

Section: Introductionmentioning

confidence: 99%

“…While its meso-and macroporosity provides space for cell seeding and bone and blood vessel ingrowth, the effective wicking of the hydrophilic micropores facilitates the migration of oxygen, nutrients, and cells via capillary forces. Scaffold resorption is mediated through phagocytosis of the nanometer sized particles as part of the remodeling of the newly formed bone [7,16,28]. This prospective randomized pilot study (EBM-Level 1) compares the results of posterior correction and fusion with the use of ultraporous b-TCP as a graft extender versus augmentation with ICBG for the treatment of AIS.…”

Section: Introductionmentioning

confidence: 99%

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A level-1 pilot study to evaluate of ultraporous β-tricalcium phosphate as a graft extender in the posterior correction of adolescent idiopathic scoliosis

et al. 2008

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The objective of this study is to compare the clinical and radiographic results of ultraporous b-tricalcium phosphate (b-TCP) versus autogenous iliac crest bone graft (ICBG), through prospective randomized pilot study (EBM-Level 1), as graft extenders in scoliosis surgery. In the posterior correction of scoliosis, local bone resected as part of the procedure is used as the base bone graft material. Supplemental grafting from the iliac crest is considered the gold-standard in posterior spinal fusion. However, autograft is not available in unlimited quantities, and bone harvesting is a source of significant morbidity. Ultraporous b-TCP might be a substitute for ICBG in these patients and thus eliminate donor site morbidity. A total of 40 patients with adolescent idiopathic scoliosis (AIS) were randomized into two treatment groups and underwent corrective posterior instrumentation. In 20 patients, ICBG harvesting was performed whereas the other half received b-TCP (VITOSS Ò ) to augment the local bone graft. If thoracoplasty was performed, the resected rib bone was added in both groups. Patients were observed clinically and radiographically for a minimum of 20 months postoperatively, with a mean follow-up of 4 years. Overall pain and pain specific to the back and donor site were assessed using a visual analog scale (VAS). As a result, both groups were comparable with respect to the age at the time of surgery, gender ratio, preoperative deformity, and hence length of instrumentation. There was no significant difference in blood loss and operative time. In nine patients of the b-TCP group and eight patients of the ICBG group, thoracoplasty was performed resulting in a rib graft of on average 7.9 g in both groups. Average curve correction was 61.7% in the b-TCP group and 61.2% in the ICBG group at hospital discharge (P = 0.313) and 57.2 and 54.3%, respectively, at follow-up (P = 0.109). Loss of curve correction amounted on average 2.6°in the b-TCP group and 4.2°in the comparison group (P = 0.033). In the ICBG group, four patients still reported donor site pain of on average 2/10 on the VAS at last follow-up. One patient in the b-TCP group was diagnosed with a pseudarthrosis at the caudal end of the instrumentation. Revision surgery demonstrated solid bone formation directly above the pseudarthrosis with no histological evidence of b-TCP in the biopsy taken. In conclusion, the use of b-TCP instead of ICBG as extenders of local bone graft yielded equivalent results in the posterior correction of AIS. The promising early results of this pilot study support that b-TCP appears to be an effective bone substitute in scoliosis surgery avoiding harvesting of pelvic bone and the associated morbidity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A level-1 pilot study to evaluate of ultraporous β-tricalcium phosphate as a graft extender in the posterior correction of adolescent idiopathic scoliosis

et al. 2008

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“…Polímeros: como Bioplan, HTR. Vidrio Cerámico bioactivo: compuesto de sales de calcio y fosfato, y sales de sodio y silicio (Biogass, Perioglass, Biogran) El principal mecanismo de acción de estos materiales es osteoconducción (30).…”

Section: D) Injertos Aloplásticos O Sintéticosunclassified

Diferentes alternativas de rellenos óseos

Tortolini¹,

Rubio²

2012

Avances en Periodoncia

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RESUMENLos recientes avances en biotecnología, el conocimiento de los factores de crecimiento y el estudio de los distintos biomateriales han desarrollado un área que se define como ingeniería tisular entendiendo por tal a la reconstrucción de nuevos tejidos para el reemplazo y la regeneración de estructuras destruidas y perdidas. La elección en la actividad clínica (tratamiento de problemas periodontales, cirugías o implantes) entre un material de relleno y otro exigen conocimientos de las propiedades histológicas normales de los tejidos y las características de los biomateriales. PALABRAS CLAVE:Ingeniería tisular, biomateriales, injertos óseo. SUMMARYRecent advances in biotechnology, knowledge of growth factors and the study of different biomaterials have developed an area which is defined as tissue engineering understood as the reconstruction of new tissues for replacement and regeneration of destroyed and lost infrastructure. The choice for clinical activity (treatment of periodontal problems, surgeries, or implants) between a filling material and other properties require knowledge of normal histology of tissues and the characteristics of biomaterials. KEY WORDS:Tissue engineering, biomaterials, bone graft. INTRODUCCIÓNLos injertos óseos tienen una función mecánica y biológica. En la interfase injerto óseo-huésped existe una compleja relación donde múltiples factores pueden intervenir para una correcta incorporación del injerto, entre ellos se encuentran la vascularización del injerto, técnicas de conservación, factores locales, factores sistémicos y propiedades mecánicas (dependen del tipo, tamaño y forma del injerto utilizado) (1).Como parte del tratamiento Periodontal de lesiones de Furca II y defectos 2 y 3 paredes la bibliografía describe el uso de biomateriales (2).Así mismo para reconstrucciones dentarias a través de tratamientos implantológicos es esencial un adecuado volumen óseo para la oseointegración (3) de allí la importancia de conocer por parte del odontó-logo el comportamiento del tejido óseo y los mecanismos biológicos por los cuales actúan los materiales.Uno de los componentes destacados del sistema estomatognático es el hueso alveolar. Esta es una estructura odontodependiente, ya que se forma junto con los elementos dentarios, los sostiene mientras cumplen su función y desaparece una vez que los dientes se pierden (4).

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“…Ceramic materials (i.e. hydroxyapatite and tricalcium phosphate blocks or cylinders) have been widely studied as potential bone graft substitutes 3,4 . Bioactive biomaterials such as bioglass, hydroxyapatite 5 and glass ceramic A-W have been known to form a bioactive bone like apatite layer spontaneously on their surfaces and bond to bone through the apatite layer in vivo 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of radial bone defects treated with autogenous graft covered with hydroxyapatite in rabbit

et al. 2012

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PURPOSE:To determine biomechanical property of autogenous bone graft covered with hydroxyapatite in the defect of radial bone in rabbit. METHODS: Eighteen adult male New Zealand white rabbits were used which were divided into three groups (I, II, III) of six rabbits each. A segmental bone defect of 10 mm in length was created in the middle of the right radial shaft under general effective anesthesia in all rabbits and were stabilized using mini-plate with four screws. The defects In group I were left as such without filler, whereas in group II the defect were filled up with harvested 10 mm rib bone and in group III the defect were packed with rib bone covered with nano-hydroxyapatite. All rabbits in three groups were divided into two subgroups (one month and three months duration with three rabbits in each one). RESULTS:The mechanical property and the mean load for fracturing normal radial bone was recorded 388.2±6 N whereas it was 72.4±12.8 N for group I in 1 month duration which was recorded 182.4±14.2 N for group II and 211.6±10.4 N for group III at the end of 1 month. These values were 97.6±10.2 N for group I and 324.6±8.2 N for group II and 372.6±17.4 N for group III at the end of three months after implantation. CONCLUSION: Implantation of autologous graft covered with hydroxyapatite indicated to have positive effect in integral formation of qualitative callus at the site of fracture and early re-organization of callus to regain mechanical strength too.

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Nonallograft Osteoconductive Bone Graft Substitutes

Cited by 321 publications

References 17 publications

A level-1 pilot study to evaluate of ultraporous β-tricalcium phosphate as a graft extender in the posterior correction of adolescent idiopathic scoliosis

A level-1 pilot study to evaluate of ultraporous β-tricalcium phosphate as a graft extender in the posterior correction of adolescent idiopathic scoliosis

Diferentes alternativas de rellenos óseos

Mechanical properties of radial bone defects treated with autogenous graft covered with hydroxyapatite in rabbit

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