Novel Optical Biosensor Based on a Nano-Gold Coated by Schiff Base Doped in Sol/Gel Matrix for Sensitive Screening of Oncomarker CA-125

Abou-Omar, Mona N.; Attia, M. S.; Afify, Hisham G.; Amin, Mohammed A.; Boukherroub, Rabah; Mohamed, Ekram H.

doi:10.1021/acsomega.1c01974

Cited by 30 publications

(7 citation statements)

References 70 publications

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“…The chemosensors based on the fluorescence method have the characteristics of a short response time, selectivity, and a wide detection range. Its basic principle is the specific interaction between the biomolecules on the sensor and the object to be analyzed [4,[150][151][152][153][154][155][156]. The light signal formed by absorption or emission band changes resulting from chemical interactions is easily detected by fluorescent molecules, with the light signal correlated with the concentration of the analyte [157][158][159][160][161][162][163][164][165].…”

Section: Optical Sensormentioning

confidence: 99%

Electrospun Nanofibers as Chemosensors for Detecting Environmental Pollutants: A Review

2023

Chemosensors

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Electrospun nanofibers have shown their advantages for applications in a wide variety of scientific fields thanks to their unique properties. Meanwhile, electrospinning is closely following the fast development of nano science and nanotechnology to move forward to smaller (pico-technology), more complicated nanostructures/nanodevices and more order (all kinds of nano arrays). Particularly, multiple-fluid electrospinning has the strong capability of creating nanostructures from a structural spinneret in a single-step and a straightforward “top-down” manner, holding great promise for creation on a large scale. This review is just to conclude the state-of-art studies on the related topics and also point out that the future directions of environmental detection require chemosensors, while the improvement of sensors requires new chemically synthesized functional substances, new nanostructured materials, application convenience, and functional integration or synergy. Based on the developments of electrospinning, more and more possibilities can be drawn out for detecting environmental pollutants with electrospun nanostructures as the strong support platform.

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Section: Optical Sensormentioning

confidence: 99%

Electrospun Nanofibers as Chemosensors for Detecting Environmental Pollutants: A Review

2023

Chemosensors

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“…Within cells, Schiff base compounds have been used as biosensors for H 2 O 2 , glucose, and Oncomarker CA-125 [87]. Evaluation of the sensitivity and specificity of the gold Schiff base complex-doped sol gel nano optical sensor for the detection of CA-125 in ovarian cancer patient samples was performed and compared to results obtained from samples taken from healthy women serving as a control group [88]. Sheta M. Sheta et al created an ultrasensitive method of detecting human creatinine using a cerium(III)-isatin Schiff base complex as an optical sensor [89].…”

Section: Bio-sensing Applicationsmentioning

confidence: 99%

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

Meena¹,

Meena²,

Kumari³

et al. 2023

Schiff Base in Organic, Inorganic and Physical Chemistry

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The development of Schiff base was a major step forward in the area of coordination chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (>C=N–) functional group. Schiff bases played an influencing role in the development of coordination chemistry and were a key point in the development of inorganic, bioinorganic chemistry and optical materials. Schiff bases, widely used in inorganic, organic, and analytical chemistry, account for a significant portion of the more commonly employed classes of organic molecules. The ability of Schiff base ligands to form stable metal complexes with a wide range of transition and other metal ions makes them extremely useful. Condensation of a primary amine with an aldehyde or ketone yields a Schiff bases. In this chapter, we focused on introducing Schiff bases, classified them and their metal complexes, and discussed several synthesis methods, including conventional and green approaches. This chapter also elaborated on the industries’ applications, such as the food industry, agrochemical industry, dye industry, analytical chemistry, catalysis, energy storage, environmental, chemo-sensing, bio-sensing, and biomedical applications of novel Schiff bases and their metal complexes.

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“…A linear response of the sensor in the concentration range of 2–127 U/mL with a LOD of 1.25 U/mL of CA125 was observed. The sensor showed the ability to discriminate between diseased people and the healthy population [ 140 ]. Omer et al exploited the optical properties of carbon quantum dots (CQDs) for the biosensing of CA125.…”

Section: Biomarkers and Their Biosensorsmentioning

confidence: 99%

Emerging Biosensing Methods to Monitor Lung Cancer Biomarkers in Biological Samples: A Comprehensive Review

Chinnappan,

Mir,

Alsalameh

et al. 2023

Cancers

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Lung cancer is the most commonly diagnosed of all cancers and one of the leading causes of cancer deaths among men and women worldwide, causing 1.5 million deaths every year. Despite developments in cancer treatment technologies and new pharmaceutical products, high mortality and morbidity remain major challenges for researchers. More than 75% of lung cancer patients are diagnosed in advanced stages, leading to poor prognosis. Lung cancer is a multistep process associated with genetic and epigenetic abnormalities. Rapid, accurate, precise, and reliable detection of lung cancer biomarkers in biological fluids is essential for risk assessment for a given individual and mortality reduction. Traditional diagnostic tools are not sensitive enough to detect and diagnose lung cancer in the early stages. Therefore, the development of novel bioanalytical methods for early-stage screening and diagnosis is extremely important. Recently, biosensors have gained tremendous attention as an alternative to conventional methods because of their robustness, high sensitivity, inexpensiveness, and easy handling and deployment in point-of-care testing. This review provides an overview of the conventional methods currently used for lung cancer screening, classification, diagnosis, and prognosis, providing updates on research and developments in biosensor technology for the detection of lung cancer biomarkers in biological samples. Finally, it comments on recent advances and potential future challenges in the field of biosensors in the context of lung cancer diagnosis and point-of-care applications.

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Novel Optical Biosensor Based on a Nano-Gold Coated by Schiff Base Doped in Sol/Gel Matrix for Sensitive Screening of Oncomarker CA-125

Cited by 30 publications

References 70 publications

Electrospun Nanofibers as Chemosensors for Detecting Environmental Pollutants: A Review

Electrospun Nanofibers as Chemosensors for Detecting Environmental Pollutants: A Review

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

Emerging Biosensing Methods to Monitor Lung Cancer Biomarkers in Biological Samples: A Comprehensive Review

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