Novel temperature and pH dual-sensitive PNIPAM/CMCS/MWCNT semi-IPN nanohybrid hydrogels: Synthesis, characterization, and DOX drug release

Luo, Yan‐Ling; Zhang, Xueyin; Fu, Jingyu; Xu, Feng; Chen, Yashao

doi:10.1080/00914037.2016.1233418

Cited by 28 publications

(15 citation statements)

References 31 publications

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“…They showed temperature and pH dual-responsiveness, and a hydrogel containing MWCNTs-COOH possessed high swelling ratios. The researchers considered that these designed nanogels could be used for the size-specific target delivery of anticancer drugs [110].…”

Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…Sensitivity to pH and temperature can be beneficial in drug delivery systems as it gives hydrogels the ability to specifically releasemedication where appropriate range of pH or temperature is desired [21][22][23]. Till date, various polymers such as xylan, poly(N-isopropylacrylamide) (PNIPAM)/carboxymethyl chitosan, β-CD-conjugated poly(ε-lysine) (βCDPL) and 3-trimethylsilylpropionic acid, poly [N,N-dimethyl aminoethyl methacrylate-copoly(poly(ethylene glycol) methyl ether methacrylate] [poly(DMAEMA-co-MPEGMA)], β-cyclodextrin, 2methylacrylic acid and N,N'-methylene diacrylamide have been used for preparing hydrogels [1].…”

Section: Hydrogelsmentioning

confidence: 99%

“…In recent years drug formulation research, one of the main focus or challenge has been as how has been the focus of many research studies to assure the safety of drug carriers to the human body with good biocompatibility and non-toxic side effects [1]. With recent advancements in drug delivery technology, several nanoparticulate drug delivery systems (NDDS) have been designed to deliver their payload specifically at the target site.…”

Section: Introductionmentioning

confidence: 99%

A Review on pH and Temperature Responsive Gels in Drug Delivery

2020

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Anticancer drugs play important roles in cancer treatment. However, these drugs have many disadvantages such as poor solubility, high toxicity, and serious side effects like hair loss, nausea and vomiting, anemia etc. To overcome these drawbacks, many attempts have been made to develop novel controlled drug delivery systems. They can encapsulate the drug and release it to the cancer site without leaking into other sites. The employment of multi-responsive hydrogels as a drug delivery system have some advantages over other drug delivery systems due to their ease of preparation, high efficiency, high-water content, tunable physical, and biological properties. The most advantages of these hydrogels is the volume phase transitions in their crosslinked three-dimensional networks as exposure to external stimuli such as temperature, pH, pressure, electric field, magnetic field and light. There has been research on other drug delivery systems which can respond to changes in pH and temperature for targeted drug release. Among those, gels have been studied mostly for their dual responsiveness. This provides an update on progress of gel based dual pH and temperature responsive drug delivery systems. Various systems under these categories for targeted and controlled delivery of different classes of drugs such as ant diabetic and antibiotic drugs with special emphasis on anticancer drugs are discussed in this review. Abstract: Biography:Ghasem Rezanejade Bardajee: He Received his Ph.D. degree in Chemistry from Sharif University of Technology. He is currently a professor at the faculty of chemistry of the Payame Noor University (Iran). His research encompasses the sensitive nanocomposite hydrogels, green chemistry, drug delivery, quantum dots, and solar cells.

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“…To be used as hydrophilic drug carriers, p NIPAm nanogels should demonstrate a VPTT higher than 37 °C and have active sites for higher drug loading capacities [ 31 , 32 ]. In order to fulfil these criteria, the p NIPAm homopolymer requires some modifications.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, its temperature sensitivity is around 30–34 °C, which is lower than the normal temperature of the human body [ 34 ]. This will lead to a premature release of drug from the hydrogel capsules due to the shrinkage of hydrogels during blood circulation in normal body fluids of 37 °C, widely distributing in vivo and giving poor therapeutic effects [ 32 ]. Setbacks related to increasing the NIPAm’s VPTT and hydrophilic drug loading can be resolved by polymerizing NIPAm with ionic comonomer (acrylic acid (AAc)) and hydrophilic crosslinker (poly(ethylene glycol) dimethacrylate (PEGDMA)).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

et al. 2018

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We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The core-shell nanogels were synthesized using an optimized two-stage seeded polymerization methodology. The core-shell nanogels show a narrow size distribution and controllable physico-chemical properties. The hydrodynamic sizes, charge distributions, temperature-induced volume phase transition behaviors, pH-responsive behaviors and drug loading capabilities of the core-shell nanogels were investigated using transmission electron microscopy, zeta potential measurements, dynamic light scattering and UV-Vis spectroscopy. The size of the core-shell nanogels was controlled by polymerizing NIPAm with crosslinker poly(ethylene glycol) dimethacrylate (PEGDMA) of different molecular weights (Mn-200, 400, 550 and 750 g/mol) during the core synthesis. It was found that the swelling/deswelling kinetics of the nanogels was sharp and reversible; with its volume phase transition temperature in the range of 40–42 °C. Furthermore, the nanogels loaded with l-3,4-dihydroxyphenylalanine (L-DOPA), using a modified breathing-in mechanism, showed high loading and encapsulation efficiencies, providing potential possibilities of such nanogels for biomedical applications.

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Novel temperature and pH dual-sensitive PNIPAM/CMCS/MWCNT semi-IPN nanohybrid hydrogels: Synthesis, characterization, and DOX drug release

Cited by 28 publications

References 31 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

A Review on pH and Temperature Responsive Gels in Drug Delivery

Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

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