Novel therapies in the management of oral cancer: An update

Nandini, DB; Rao, Roopa S; Hosmani, Jagadish; Khan, Samar; Patil, Shankargouda; Awan, Kamran Habib

doi:10.1016/j.disamonth.2020.101036

Cited by 53 publications

(37 citation statements)

References 30 publications

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“…Currently, the treatment strategy of oral cancer is mainly surgery, with or without radiotherapy, chemotherapy, targeted biological therapy, and immunotherapy as adjuvant therapy. However, early diagnosis, adverse effects, recurrence, and metastasis are still difficult problems in clinical treatment 3–5 . Thus, pursuing effective treatments is in urgent need.…”

Section: Introductionmentioning

confidence: 99%

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

Lou

Hou

et al. 2022

J Oral Pathology Medicine

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Background: We aimed to demonstrate the effects circ_0058063 exerted on oral squamous cell carcinoma (OSCC) and its downstream mechanism associated with miR-145-5p and SERPINE1. Methods:The relevant contents of miR-145-5p, circ 0058063, and SERPINE1 mRNAs in OSCC were evaluated using quantitative reverse transcription polymerase chain reaction. Functional experiments including CCK-8, Transwell, Western blot, and in vivo experiment were implemented to investigate the biological impacts on OSCC cells. Using dual-luciferase reporter, RIP, and RNA pull-down assays, the direct binding relationship between miR-145-5p, circ 0058063, and SERPINE1, SMAD3, CYR61, and IGF1R mRNAs was verified.Results: In OSCC, Circ 0058063 was significantly overexpressed. Knockdown of circ_0058063 suppressed OSCC cell migration and proliferation, but enhanced cell apoptosis. Functionally and mechanistically, circ_0058063 could specifically bind with miR-145-5p and thus upregulated expression of downstream target SERPINE1, which together contributed to the progression of OSCC. Conclusion:Circ_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR-145-5p.

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Section: Introductionmentioning

confidence: 99%

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

Lou

Hou

et al. 2022

J Oral Pathology Medicine

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“…Oropharyngeal cancer accounts for approximately 4% of all cancers [1], and most of diagnosed cases are squamous cell carcinoma (SCC) [2].…”

Section: Introductionmentioning

confidence: 99%

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Mostafa

El-Bolok

Fahmi

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Oral squamous cell carcinoma is accounting for almost 90% of oropharyngeal cancer diagnoses. Natural herbal medicine can use as an alternative, or complementary, or adjunctive for cancer treatment. Frankincense and its combination with myrrh have anticancer effects on different cancer types. METHODS: In this research, aqueous and methanolic extracts of frankincense and the combination of aqueous extract of frankincense and myrrh were applied on tongue squamous cell carcinoma cell line to study their cytotoxic and apoptotic effect by the assessment of cell viability and cytotoxicity, caspase 3 and 8 activation, reactive oxygen species activity, mitochondrial membrane potential, morphological changes, and nuclear area factor measurements. RESULTS: The result showed that aqueous and methanolic extracts of frankincense have cytotoxic and apoptotic effects in a concentration-dependent manner with an IC50 value of 21.05 ± 1.27 μM for aqueous extract, 36.72 ± 2.07 μM for methanolic extract, and IC50 value of 1.31 ± 0.04 μM for combination of aqueous extract of frankincense and myrrh extract after 24 h. CONCLUSION: Different extracts of frankincense and the combination of aqueous extract of frankincense and myrrh extract exhibited cytotoxic and apoptotic effects by reducing the cell viability and activating caspases 3 and 8 causing intrinsic- and extrinsic-mediated apoptosis pathways activation with the involvement of oxidative stress that was conceivable with cytonuclear morphological alterations results.

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“…Epithelial cells are mainly affected in oral cancer, may enlarge metastasis, and even lead to death [12]. Oral squamous cell carcinomas (OSCC) are a dangerous factor for over 90% of all oral cancers [13]. The mucosa of the tongue, the floor of the mouth, buccal, alveolar, and the hard palate mainly invaded by these cancers, and the most commonly reported subsite is the tongue with a poor prognosis [14].…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers

Kumar¹,

Khan²,

Ranjan³

et al. 2021

Adv. Mater. Lett.

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Novel therapies in the management of oral cancer: An update

Cited by 53 publications

References 30 publications

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers

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