Nuclear Magnetic Resonance (NMR) Analysis of D - (+) - Glucose: A Guide to Spectrometric Structural Elucidation of Sugars

Phytochemical investigation of methanolic extract of L. rubiginosa using modern chromatographic techniques has led to the isolation of three new triterpenoid saponins, lepiginosides A-C (1-3), a new farnesyl glycoside, lepiginoside D (4), together with lepisantheside B (5) and gleditsoside C (6). The characterization and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. Moreover, the antibacterial activity against seven bacteria, but none is active.

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Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

Limjiasahapong

Tuchinda

Reutrakul

et al. 2018

Natural Product Communications

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The first phytochemical investigation of the leaves and twigs of Santisukia pagetii (Bignoniaceae) using a bioassay-guided fractionation led to the isolation and identification of seventeen known compounds, including four triterpenoids, 3-O-acetylpomolic acid (1), ursolic acid (2), 3-O-acetylursolic acid (3) and siaresinolic acid (4), three iridoid glycosides, specioside (5), verminoside (6) and ambiguuside (7), three flavonoid glycosides, luteolin-7-O-neohesperidoside (8), apigenin-7-O-neohesperidoside (9) and isoquercitrin (10), two phenolic compounds, p-coumaric acid (11) and caffeic acid (12), one monoterpenoid, (6S)-menthiafolic acid (13), together with α-D-glucose (14), β-D-maltose (15), β-sitosterol 3-O-β-D-glucopyranoside (16), a mixture of β-sitosterol (17A) and stigmasterol (17B). Compounds 113 were isolated from Santisukia genus for the first time. In addition, compounds 17, 9 and 10 were found to be active against HIV-1 in anti-syncytium assay, while only compounds 1 and 3 were found to be active (84.4% and 87.2% inhibition at 200 µg/mL, with IC 50 values of 290.96 and 210.34 µM, respectively) against HIV-1 reverse transcriptase. Moreover, anti-HIV-1 activities of compounds 1, 38, and 13 were reported for the first time.

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Nuclear Magnetic Resonance (NMR) Analysis of D - (+) - Glucose: A Guide to Spectrometric Structural Elucidation of Sugars

Cited by 5 publications

References 11 publications

Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance Spectroscopy

Lepiginosides A-D: three new triterpenoid saponins and a new farnesyl glycoside from the stembarks of Lepisanthes rubiginosa (roxb.) leenh

Anti-HIV-1 Activities and Chemical Constituents from Leaves and Twigs of Santisukia pagetii (Bignoniaceae)

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