Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging

Zhao, Zhenghuan; Zhou, Zijian; Bao, Jianfeng; Wang, Zhenyu; Hu, Juan; Chi, Xiaoqin; Ni, Kaiyuan; Wang, Ruifang; Chen, Xiaoyuan; Chen, Zhong; Gao, Jinhao

doi:10.1038/ncomms3266

Cited by 435 publications

(546 citation statements)

References 48 publications

Supporting

Mentioning

513

Contrasting

Order By: Relevance

“…Such a variable behavior has been explained by simulations, which took into account the surface spin structure of different-shaped particles that were proven to incorporate a lower number of disordered spins responsible for cubic (4%) more than for spherical (8%) particles [60]. According to these finding, careful engineering of the shape anisotropy of the nanocrystals is, in turn, shown to be beneficial to magnetic resonance imaging (MRI) relaxivities [65] and magnetic heat generation [66,67] efficacies. Overall, faceted particles are found to exhibit higher relaxivity for dark contrast generation and increased heat dissipation capability compared to the isotropic spherical ones due to their enhanced and cooperative magnetic properties [60,[68][69][70].…”

Section: Introductionmentioning

confidence: 99%

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Κωστοπούλου

Lappas

2015

Nanotechnology Reviews

View full text Add to dashboard Cite

Magnetic particles of optimized nanoscale dimensions can be utilized as building blocks to generate colloidal nanocrystal assemblies with controlled size, well-defined morphology, and tailored properties. Recent advances in the state-of-the-art surfactant-assisted approaches for the directed aggregation of inorganic nanocrystals into cluster-like entities are discussed, and the synthesis parameters that determine their geometrical arrangement are highlighted. This review pays attention to the enhanced physical properties of iron oxide nanoclusters, while it also points to their emerging collective magnetic response. The current progress in experiment and theory for evaluating the strength and the role of intra-and inter-cluster interactions is analyzed in view of the spatial arrangement of the component nanocrystals. Numerous approaches have been proposed for the critical role of dipole-dipole and exchange interactions in establishing the nature of the nanoclusters' cooperative magnetic behavior (be it ferromagnetic or spin-glass like). Finally, we point out why the purposeful engineering of the nanoclusters' magnetic characteristics, including their surface functionality, may facilitate their use in diverse technological sectors ranging from nanomedicine and photonics to catalysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Κωστοπούλου

Lappas

2015

Nanotechnology Reviews

View full text Add to dashboard Cite

show abstract

“…Our group achieved the controlled synthesis of Ag NCs with size less than 4 nm by decomposition of Ag-oleate complexes in the presence of oleic acid and dodecylamine [302]. Another example is the formation and use of iron-oleate complexes in the controlled synthesis of octapod iron oxide, which was reported by Gao and co-workers [303]. However, since the reduction of iron requires much more rigid conditions, the decomposition of iron-oleate without the addition of strong reductant just leads to the generation of oxides.…”

Section: Decomposition For Metalsmentioning

confidence: 99%

Understanding of the major reactions in solution synthesis of functional nanomaterials

Wang

2016

Sci. China Mater.

View full text Add to dashboard Cite

This review covers the major reactions involved in the solution synthesis of nanomaterials. It was designed to classify the traditional strategies such as precipitation, reduction, seed growth, etching, and so on into two basic processes which are termed as bottom-up and top-down routines. The discussion is focused on the basic mechanism and principles during the nucleation and growth of nanocrystals, especially in the solution system. This review also presents a prediction for how to utilize these intrinsic processes to artificially construct the desired specific and functional nanostructures. We try to describe the most directive and effective way to control the structures of nanocrystals for researchers who can master the major reaction mechanism and grasp the basic technologies in synthetic nanoscience.

show abstract

“…It is easier and more cost effective to tune the physicochemical properties of NPs than NP functionalization with specific targeting ligands. Recently, Zhao et al, 48 demonstrated that the morphology of iron oxide NPs affects the MR imaging efficacy. They revealed that the octapod iron oxide NPs show higher contrast in T2 imaging of liver cancer compared to spherical model (with the same geometry).…”

Section: Liver Cancermentioning

confidence: 99%

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Bakhtiary

Saei

Hajipour

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

152

View full text Add to dashboard Cite

Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into the blood stream. This concentrates the NPs in the desired tumor location. Furthermore, such receptor-specific targeting may be exploited for detection of potential metastases in an early stage. Some NPs, such as superparamagnetic iron oxide NPs (SPIONs), are also compatible with magnetic resonance imaging (MRI), which makes their clinical translation and application rather easy and accessible for tumor imaging purposes. Furthermore, multifunctional and/or theranostic NPs can be used for simultaneous imaging of cancer and drug delivery. In this review article, we will specifically focus on the application of SPIONs in early detection and imaging of major cancer types.From the Clinical Editor: Super-paramagnetic iron oxide nanoparticles (SPIONs) have been reported by many to be useful as an MRI contrast agent in the detection of tumors. To further enhance the tumor imaging, SPIONs can be coupled with tumor targeting motifs. In this article, the authors performed a comprehensive review on the current status of using targeted SPIONS in tumor detection and also the potential hurdles to overcome. © 2015 Elsevier Inc. All rights reserved. 1 A significant improvement in cancer survival has been noted over the past three decades for most cancer types. This notable and continuous decrement in tumor fatality is related to advanced development in prevention, early diagnosis and therapeutic approaches and decrease in overall prevalence of smoking.1 Early detection of cancer, especially before cancer cells metastasize, is critical for cancer diagnosis, because early stage cancers can be treated more effectively. However, early-stage diagnosis has been difficult to achieve in most cases since clinical symptoms tend to show up at later stages. Therefore, minimally-and non-invasive methods for early detection of cancer are urgently needed in the field. In this regard, many SPION-based systems are under development for more sensitive imaging and earlier detection of tumors. Since non-targeted SPION species cannot readily differentiate cancer tissues from normal tissues, second-generation SPIONs have been developed which are equipped with targeting moieties that can recognize Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) 287 -307

show abstract

Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging

Cited by 435 publications

References 48 publications

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

Understanding of the major reactions in solution synthesis of functional nanomaterials

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Contact Info

Product

Resources

About