Ocular hazards of blue-light therapy in dermatology

Walker, Daniel P.; Vollmer-Snarr, Heidi R.; Eberting, Cheryl Lee

doi:10.1016/j.jaad.2010.11.040

Cited by 15 publications

(16 citation statements)

References 64 publications

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“…High‐energy visible light phototherapy is applied in the treatment of a number of benign and malignant skin disorders including acne, atopic dermatitis, psoriasis, actinic keratosis, and basal cell carcinoma . For phototherapy of eczema, UV‐free blue light is effective, with local hyperpigmentation as the only side effect .…”

Section: Discussionmentioning

confidence: 99%

“…47 High-energy visible light phototherapy is applied in the treatment of a number of benign and malignant skin disorders including acne, atopic dermatitis, psoriasis, actinic keratosis, and basal cell carcinoma. 86 For phototherapy of eczema, UV-free blue light is effective, with local hyperpigmentation as the only side effect. 87 However, the numerous and partly contradictory effects on skin cells depending on dose and wavelength must be considered, especially as the clinical relevance and interdependence of the biological responses are not yet fully understood.…”

Section: F I G U R Ementioning

confidence: 99%

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High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

Mann

Eggers

Rippke

et al. 2019

Photoderm Photoimm Photomed

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Background Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV‐induced ROS, they cannot prevent VIS‐induced (400‐760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products. Methods We investigated VIS‐induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA). Results Visible spectrum of 400‐500 nm dose‐dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm2). A pretreatment for 24 hours with 1 µmol/L LicA reduced ROS formation to the level of unirradiated cells while UV filters alone were ineffective, even at SPF50+. In vivo, topical treatment with a LicA‐containing SPF50 + formulation significantly prevented the depletion of intradermal carotenoids by VIS irradiation while SPF50 + control did not protect. Conclusion LicA may be a useful additive antioxidant for sunscreens.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

Mann

Eggers

Rippke

et al. 2019

Photoderm Photoimm Photomed

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“…Proper exposure to sunlight is beneficial to our health, but high‐energy photons (wavelength shorter than 450 nm) can be very harmful to human beings, including photons in the ultraviolet (UV) and short‐wavelength blue light (SWB) regions. UV radiation can directly damage biotic tissue and cause severe diseases, such as skin cancer, and excessive exposure to SWB light may cause chronobiology disorders or eye diseases, such as myopia and maculopathy . Currently, light pollution is becoming increasingly worse owing to the development of artificial illumination and the excessive applications of architectural glass, especially in urban areas.…”

Section: Introductionmentioning

confidence: 99%

Transparent Schottky Photodiode Based on AgNi NWs/SrTiO₃ Contact with an Ultrafast Photoresponse to Short‐Wavelength Blue Light and UV‐Shielding Effect

Yang

Yong

Zhang

et al. 2019

Adv Funct Materials

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A transparent Schottky photodiode is constructed based on a SrTiO3 (STO) wafer, in which nickel‐coated silver nanowires (AgNi NWs) are proposed as the high‐work‐function transparent electrode. A selective photoresponse to harmful short‐wavelength blue (SWB) light is generated owing to the proper bandgap of STO, and the AgNi NWs effectively strengthen the photovoltaic behavior, resulting in an ultrafast response speed (trise/tfall = 7 µs/115 µs) and photocurrent of 16–38 nA under a 0 V bias. Meanwhile, the complete device maintains a transparency of ≈60% almost over the entire visible light region and blocks 96.7% UVA and >99.9% UVB. The combination of bias‐free SWB detection and transparent UV shielding is readily applicable to protect against light pollution. Furthermore, this work proposes a considerable method to modulate the work function of transparent Ag NW electrodes by surface coating, which provides inspiration for the development of transparent electrode materials with different work functions.

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“…Although phototherapy with blue light has become important in the treatment of many dermatologic conditions [36] and even some reports indicate that exposure to blue light can be used in the treatment of superficial skin carcinomas in humans [37], substantial evidence now shows that in a similar pattern to that caused by exposure to infrared (IR) or ultraviolet (UV), at high level, exposure to blue-violet light can be associated with some adverse effects in human skin [38].…”

Section: Introductionmentioning

confidence: 99%

Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?

et al. 2018

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Since the early days of human life on the Earth, our skin has been exposed to different levels of light. Recently, due to inevitable consequences of modern life, humans are not exposed to adequate levels of natural light during the day but they are overexposed to relatively high levels of artificial light at night. Skin is a major target of oxidative stress and the link between aging and oxidative stress is well documented. Especially, extrinsic skin aging can be caused by oxidative stress. The widespread use of light emitting diodes (LEDs) and the rapidly increasing use of smartphones, tablets, laptops and desktop computers have led to a significant rise in the exposure of human eyes to short-wavelength visible light. Recent studies show that exposure of human skin cells to light emitted from electronic devices, even for exposures as short as 1 hour, may cause reactive oxygen species (ROS) generation, apoptosis, and necrosis. The biological effects of exposure to short-wavelength visible light in blue region in humans and other living organisms were among our research priorities at the Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC). Today, there is a growing concern over the safety of the light sources such as LEDs with peak emissions in the blue light range (400-490 nm). Recent studies aimed at investigating the effect of exposure to light emitted from electronic device on human skin cells, shows that even short exposures can increase the generation of reactive oxygen species. However, the biological effects of either long-term or repeated exposures are not fully known, yet. Furthermore, there are reports indicating that frequent exposure to visible light spectrum of the selfie flashes may cause skin damage and accelerated skin ageing. In this paper we have addressed the different aspects of potential effects of exposure to the light emitted from smartphones’ digital screens as well as smartphones’ photoflashes on premature aging of the human skin. Specifically, the effects of blue light on eyes and skin are discussed. Based on current knowledge, it can be suggested that changing the spectral output of LED-based smartphones’ flashes can be introduced as an effective method to reduce the adverse health effects associated with exposure to blue light.

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Ocular hazards of blue-light therapy in dermatology

Cited by 15 publications

References 64 publications

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

Transparent Schottky Photodiode Based on AgNi NWs/SrTiO₃ Contact with an Ultrafast Photoresponse to Short‐Wavelength Blue Light and UV‐Shielding Effect

Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?

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Ocular hazards of blue-light therapy in dermatology

Cited by 15 publications

References 64 publications

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

Transparent Schottky Photodiode Based on AgNi NWs/SrTiO3 Contact with an Ultrafast Photoresponse to Short‐Wavelength Blue Light and UV‐Shielding Effect

Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?

Contact Info

Product

Resources

About

Transparent Schottky Photodiode Based on AgNi NWs/SrTiO₃ Contact with an Ultrafast Photoresponse to Short‐Wavelength Blue Light and UV‐Shielding Effect