Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab

Asano, Takao; Kunikata, Hiroshi; Yasuda, Masayuki; Nishiguchi, Koji M.; Abe, Toshiaki; Nakazawa, Toru

doi:10.1007/s10792-020-01562-7

Cited by 3 publications

(3 citation statements)

References 50 publications

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“…The LSCI has proven to be a simple and versatile tool to visualize the structure of capillary and to monitor blood flow including cortical [24,25], neurovascular [26,27], retinal blood flow [28][29][30], dermal blood flow [31][32][33][34], etc. This study evaluated the potential of combining the LSCI and ADF filter as a tool for monitoring transient thermal responses of blood vessel during laser irradiation.…”

Section: Discussionmentioning

confidence: 99%

Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging

et al. 2022

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Real-time monitoring of blood flow and thrombosis formation induced by laser irradiation is critical to reveal the thermal-damage mechanism and successfully implement vascular-dermatology laser surgery. Laser speckle contrast imaging (LSCI) is a non-invasive technique to visualize perfusion in various tissues. However, the ability of the LSCI to monitor the transient thermal response of blood vessels, especially thrombus formation during laser irradiation, requires further research. In this paper, an LSCI system was constructed and a 632 nm He-Ne laser was employed to illuminate a Sprague Dawley rat dorsal skin chamber model irradiated by a 1064 nm Nd: YAG therapy laser. The anisotropic diffusion filtering (ADF) technique is implemented after temporal LSCI (tLSCI) processing to improve the SNR and temporal resolution. The speckle flow index is used to characterize the blood-flow velocity to reduce the computational cost. The combination of the tLSCI and ADF increases the temporal resolution by five times and the SNR by 17.2 times and 16.14 times, without and with laser therapy, respectively. The laser-induced thrombus formation and vascular damage during laser surgery can be visualized without any exogenous labels, which provides a powerful tool for thrombus monitoring during laser surgery.

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Section: Discussionmentioning

confidence: 99%

Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging

et al. 2022

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“…According to the study by Asano et al, 6-month post-IVR BCVA was positively associated with pre-IVR systolic blood pressure (SBP). Furthermore, a multiple regression analysis revealed that pre-IVR SBP was an independent predictor of 6-month post-IVR BCVA ( 33 ). Their findings may not be representative because of the small number of patients enrolled.…”

Section: Systemicmentioning

confidence: 99%

“…Their results showed that pre-IVR, 1-month, 6-month post-IVR, overall MBR, and vessel MBR were all negatively correlated with 6-month post-IVR logMAR BCVA. Furthermore, a multiple regression analysis revealed that pre-IVR overall MBR was the independent prognostic factor of 6-month post-IVR logMAR BCVA ( 33 ). Matsumoto et al ( 96 ) measured the MBR of the ONH in patients with CRVO to assess microcirculation at the ONH.…”

Section: Laser Speckle Flowgraphymentioning

confidence: 99%

Potential Prognostic Indicators for Patients With Retinal Vein Occlusion

et al. 2022

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The second most prevalent cause of retinal vascular disease is retinal vein occlusion (RVO). RVO raises intravascular pressure in the capillary and veins, triggering vessel barrier collapse and subsequent leaking of blood or plasma components into the tissue (edema). Macular edema (ME) is a major complication of RVO that results in significant visual impairment. Laser therapy, intravitreal steroid injections, and vascular endothelial growth factor (VEGF) inhibitors are the major therapeutic techniques. Different therapies reduce ME of RVO and improve visual activity. However, some people have no impact on the resolution of ME, while others have a poor visual prognosis despite full ME cure. There are many investigators who studied the relationship between indicators of various instruments with visual activity. However, a summary of those findings is currently lacking. Therefore, we will focus on the predictive factors of different studies associated with positive visual activity outcomes, which would be very useful and important to help address both treatment expectations and methods for patients with RVO.

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Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab

Takizawa,

Yasuda,

Hoshi

et al. 2024

Int Ophthalmol

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Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab

Cited by 3 publications

References 50 publications

Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging

Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging

Potential Prognostic Indicators for Patients With Retinal Vein Occlusion

Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab

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