On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone

Dänicke, Sven; Brüssow, Klaus‐Peter; Valenta, Hana; Ueberschär, Karl‐Heinz; Tiemann, Ute; Schollenberger, Margit

doi:10.1002/mnfr.200500050

Cited by 71 publications

(58 citation statements)

References 27 publications

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“…Urine seems to be the main route of excretion of DON in ruminants; faecal and bilary excretion seems to be less important [2,6]]. However, it has been shown for pigs that the DON and DOM-1 concentration in bile increases with the DON intake [38]. In the current study, the DOM-1 concentrations in bile were linearly related to the DON intake (Fig.…”

Section: General Aspects Of Residues In Serum Milk and Bilementioning

confidence: 61%

No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions

Keese

Meyer

Valenta

et al. 2008

Molecular Nutrition Food Res

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To examine the carry over of deoxynivalenol (DON) and its metabolite de-epoxy DON (DOM-1) in milk, lactating German Holstein cows (n = 13) were fed an isoenergetic total mixed ration in Period 1 with 50% concentrates and 5.3 mg DON/kg dry matter (DM) over 11 wk and were compared with control cows (n = 14). In Period 2 (18 wk), an elevated concentrate proportion was compared to a low concentrate ration by dividing the cows into four Groups (n = 8): Control-30 (30% concentrates), Myco-30 (30% concentrates, 4.4 mg DON/kg DM), Control-60 (60% concentrates) and Myco-60 (60% concentrates, 4.6 mg DON/kg DM). Taken both periods together, no unmetabolised DON was detected in milk samples using the HPLC-UV method. DOM-1 concentrations ranged between below the LOD and 3.2 microg/kg milk in mycotoxin fed cows, while control cows did not excrete any measurable amounts of DOM-1. Regarding the concentrate effects, the carry over of DON as DOM-1 in milk was negligible (between 0.0001 and 0.0011) but significantly higher in Group Myco-30 than in Group Myco-60. This effect may result from an altered bioavailability of DON from maize silage which made up a higher proportion of the daily ration.

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Section: General Aspects Of Residues In Serum Milk and Bilementioning

confidence: 61%

No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions

Keese

Meyer

Valenta

et al. 2008

Molecular Nutrition Food Res

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“…Several authors showed that increasing DON-concentrations in feed may gradually reduce growth performance and feed intake of pigs Swamy et al 2003;Da¨nicke et al 2004cDa¨nicke et al , 2005, particularly in young pigs (Andretta et al 2012). Moreover, no significant difference in the serum:feed ratio of DON was found in piglets fed the DON'PC diet compared with those fed the control diet, suggesting that PC additive did not inactivate DON, but may decrease the adverse effects of DON through a reduction of the toxic effect of DON.…”

Section: Effects Of Don and Anti-mycotoxin Additives On Growth Performentioning

confidence: 99%

“…(1 feed) has been shown to induce anorexia, decrease weight gain and impair the immune system, resulting in an increased incidence of infectious diseases and digestive disorders (Rotter et al 1994;Do¨ll et al 2003;Swamy et al 2003;Da¨nicke et al 2004cDa¨nicke et al , 2005Da¨nicke et al , 2007Pinton et al 2008). Acute higher doses induce feed refusal, increased salivation, vomiting, hemorrhagic diarrhea and circulatory shock (Pestka and Smolinski 2005;Pinton et al 2008).…”

mentioning

confidence: 99%

The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance, intestinal barrier function and nutrient digestibility and retention in weanling pigs

et al. 2015

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. 2015. The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance, intestinal barrier function and nutrient digestibility and retention in weanling pigs. Can. J. Anim. Sci. 95: 197Á209. This study was designed to determine the effect of feeding deoxynivalenol (DON) contaminated wheat to growing pigs on growth performance, digestibility and retention of nitrogen (N), phosphorus (P) and calcium (Ca). Secondly, we wished to evaluate the potential of four commercial anti-mycotoxin additives in preventing the adverse effects of DON. Sixty piglets (6.0 kg body weight) were assigned to six different corn-soybean meal-wheat diets (control diet: B0.5 mg kg(1 DON; contaminated diet (DONcontaminated): 4 mg kg (1 ; and four contaminated diets supplemented with a different anti-mycotoxin additive: DON' GLUC (glucomannan), DON'YBP (yeast, live bacteria, enzymes, plant extracts), DON'ALU (aluminosilicate) and DON'PC (preservation components). Piglets were housed individually in pens for 7 d and then transferred to metabolic crates for urine and feces collection for 7 d. At the end of these 2 wk, mannitol and lactulose doses were given by oral administration. Urine was collected for 24 h for an evaluation of barrier integrity of intestinal mucosa. The piglets were then euthanatized and intestinal samples collected for morphology studies. Feeding DON-contaminated wheat reduced average daily feed intake, average daily gain and G:F ratio compared with the control diet (PB0.05). Only DON'PC diet restored the growth performance of piglets fed DON-contaminated diet. Daily retention of N and P was not affected by DON contamination or anti-mycotoxin additives, but retention of Ca was higher in piglets fed the DON-contaminated diets than the control diet. DON-contaminated diet reduced digestibility of dry matter, gross energy and fat, villi height in jejunum, and recovery of mannitol and lactulose compared with the control diet (PB0.05). Finally, DON concentrations in serum from piglets fed the DON-contaminated diets were higher than in the control diet (PB0.05). Piglets fed DONcontaminated wheat had reduced growth possibly caused by impaired jejunal morphology and decreased digestibility of energy and fat.

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“…Only bile and kidney contained detectable concentrations of DOM, the metabolite of DON while in trials incorporating higher concentrations of DON in the diets DOM could also be detected in muscle, liver, and serum [4,20].…”

Section: Discussionmentioning

confidence: 94%

“…The detection limit was 30 ng/g and the mean recovery was approximately 95%. Freeze-dried liver, kidney, muscle, bile, and serum samples were analyzed for DON and de-epoxy-DON (DOM) by HPLC with UV detection after incubation with b-glucuronidase (EC 3.2.1.31; Type H-2, Sigma -Aldrich Chemie, Taufkirchen, Germany) [4,11]. The detection limit was 4 ng/g for freeze-dried liver, kidney, and muscle and 4 ng/mL for bile and 2 ng/mL for serum with a mean recovery between 87 -95 and 86 -97% for DON and DOM, respectively.…”

Section: Analysesmentioning

confidence: 99%

Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations

Döll

Dänicke

Valenta

2008

Molecular Nutrition Food Res

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Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON (DOM) were analyzed in specimens of pigs fed diets containing 0, 25, and 50% contaminated wheat (2.5 mg DON/kg) fed as mash or pellets over the final growing period of 11 wk. Median DON concentrations decreased from bile > kidney > serum > liver = muscle, while DOM was only detected in bile and kidney. Maximum carry over rates were 0.0319 for kidney, 0.0064 for liver, and 0.0043 for muscle, demonstrating that the contribution of animal derived food to the consumers' exposure is very low. The high interindividual variation of DON concentrations in all analyzed specimen of pigs fed diets containing similar concentrations of DON does not allow a diagnostic differentiation of animals fed diets containing DON concentrations of approximately 61% of the guidance level of 0.9 mg DON/kg, and those fed diets containing 137% of this concentration. The different feed forms did not affect residue concentrations in any of the investigated specimens.

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On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone

Cited by 71 publications

References 27 publications

No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions

No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions

The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance, intestinal barrier function and nutrient digestibility and retention in weanling pigs

Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations

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