Optic Parameters of a Middle-Focus Kumakhov Lens for Hard X-rays

Romanov, A. Yu.

doi:10.1134/1.1894431

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…These can be described as soft x-rays and more easily absorbed by the brain tissues. Also, polycapillary optics has recently been made for focusing of higher energy x-rays up to 60 keV, although transmission through these lenses is <5% at energies higher than 5 keV 47 .…”

Section: X-ray Focusingmentioning

confidence: 99%

X-Optogenetics and U-Optogenetics: Feasibility and Possibilities

et al. 2015

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Optogenetics as developed by Dr. Karl Deisseroth and others has been a transformative technology in the area of neuroscience. By stimulating genetically-modified neurons with visible light, modulation of the ionic conduction across the cell membrane can be achieved with very high specificity and precise temporal control. Despite the major influence of this technique, its scope is limited by its invasive nature and its lack of stimulation depth.

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Section: X-ray Focusingmentioning

confidence: 99%

X-Optogenetics and U-Optogenetics: Feasibility and Possibilities

et al. 2015

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“…The main working energy range of the existing devices of the x-ray polycapillary technology is approximately from 0.5 to 30 keV. Recent advances allow the device to focus high energy x-rays up to 60 keV that open new possibilities for wide applications of the x-ray polycapillary focusing mechanism [16], [17]. Hence, it is feasible to use focused x-rays to excite LINPs for x-ray fluorescence imaging.…”

Section: Introductionmentioning

confidence: 99%

X-Ray Fluorescence Computed Tomography With Polycapillary Focusing

Cong

Wang

2014

IEEE Access

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Liposomal iodine nanoparticles (LINPs) have a long half-life and provide an excellent intravascular contrast. The nanoparticles can be functionalized as molecular probes for biological targets to facilitate numerous preclinical studies for translation toward diagnosis and therapy of various human diseases. Iodine has a K-edge at 33 keV due to the photoelectric absorption of photons, which emit X-ray fluorescence at 28 keV with a fluorescence yield of 0.88. Detections of the characteristic X-rays can be used for the imaging of iodine concentration distribution in an object. In this paper, we propose an X-ray fluorescence computed tomography method for reconstruction of a LINPs distribution over a region of interest (ROI) in a small animal. X-rays are focused onto a submillimeter focal spot utilizing a polycapillary lens, generating a pair of X-ray cones in the animal. This focused beam irradiates LINPs, the most strongly at the focal spot. Then, the focal spot can be scanned over an ROI in the object to produce X-ray fluorescence signals. From measured fluorescence data, a reliable image reconstruction can be achieved with a high spatial resolution. Numerical simulation studies are performed to demonstrate the superior imaging performance of this methodology.INDEX TERMS Liposomal iodine nanoparticles, polycapillary lens, x-ray fluorescence CT, image reconstruction, compressed sensing.

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“…Nowadays, based on polycapillary optics, new-generation devices are developed [2] because of the distinctive features of polycapillary optics such as large angular aperture (∼0.1 rad) and broad-band energy spectrum (0.1-60 keV [3]). Application of polycapillary optics to conventional low-power X-ray tubes allows receiving X-ray microbeams with high density of a flux.…”

Section: Introductionmentioning

confidence: 99%

X-ray microbeams based on Kumakhov polycapillary optics and its applications: Analytical consideration

Romanov¹

2011

Pramana - J Phys

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Kumakhov polycapillary optics is based on the effective passage of X-ray radiation through bundles of monocapillaries of various configurations. The passage of radiation takes place because of the total external reflection of X-rays from the inner capillary walls. In this work, the basic characteristics of intense quasi-parallel X-ray polycapillary microbeams from a laboratory source with microfocus X-ray tube/polycapillary cylindrical structure are investigated theoretically (analytical consideration). The data generated from theoretical estimations are compared with the experimental results. Several new generations of X-ray analytical devices like, laboratory synchrotron, fluorescent spectrometers, reflectometers/refractometers, diffractometers, X-ray microscopes and combinations of several such devices, are developed based on polycapillary optics. Besides, a number of devices can be developed for the most modern research problems such as nanomateriology, namely, X-ray nanoscanner, portable X-ray nanothickness indicator etc. X-ray tubes and the radiators, specially developed for polycapillary optics as efficiently as possible, are used in all the devices mentioned above.

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Optic Parameters of a Middle-Focus Kumakhov Lens for Hard X-rays

Cited by 6 publications

References 7 publications

X-Optogenetics and U-Optogenetics: Feasibility and Possibilities

X-Optogenetics and U-Optogenetics: Feasibility and Possibilities

X-Ray Fluorescence Computed Tomography With Polycapillary Focusing

X-ray microbeams based on Kumakhov polycapillary optics and its applications: Analytical consideration

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