Optical imaging: new tools for arthritis

Chamberland, David L.; Jiang, Yanyun; Wang, Xueding

doi:10.1039/b926506f

Cited by 33 publications

(28 citation statements)

References 83 publications

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“…[5][6][7][8] However, the reported techniques utilized monochromatic light, and thus did not explore the richness of the spectral information obtained using a broadband light. Spectroscopic data carry useful information about tissue optical properties such as absorption, scattering, and tissue composition.…”

Section: Introductionmentioning

confidence: 99%

“…5 All these techniques have drawbacks such as the need for ionizing radiation and low sensitivity in early arthritis for x-ray; high variability between operators and long examination time for thorough imaging of multiple joints for ultrasound; high costs, long intermediate examination time, and limited availability for magnetic resonance imaging (MRI). An imaging modality for diagnosis of arthritis addressing all these drawbacks is thus needed.…”

Section: Introductionmentioning

confidence: 99%

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Hyperspectral imaging for detection of arthritis: feasibility and prospects

2015

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Abstract. Rheumatoid arthritis (RA) is a disease that frequently leads to joint destruction. It has a high incidence rate worldwide, and the disease significantly reduces patients' quality of life. Detecting and treating inflammatory arthritis before structural damage to the joint has occurred is known to be essential for preventing patient disability and pain. Existing diagnostic technologies are expensive, time consuming, and require trained personnel to collect and interpret data. Optical techniques might be a fast, noninvasive alternative. Hyperspectral imaging (HSI) is a noncontact optical technique which provides both spectral and spatial information in one measurement. In this study, the feasibility of HSI in arthritis diagnostics was explored by numerical simulations and optimal imaging parameters were identified. Hyperspectral reflectance and transmission images of RA and normal human joint models were simulated using the Monte Carlo method. The spectral range was 600 to 1100 nm. Characteristic spatial patterns for RA joints and two spectral windows with transmission were identified. The study demonstrated that transmittance images of human joints could be used as one parameter for discrimination between arthritic and unaffected joints. The presented work shows that HSI is a promising imaging modality for the diagnostics and follow-up monitoring of arthritis in small joints. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperspectral imaging for detection of arthritis: feasibility and prospects

2015

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“…[2][3][4] The spatial resolution of DOT, however, is limited by it's dependence on diffused photons as detection signals. Integrating the structural information extracted from secondary imaging modalities, such as US, can improve the image quality of DOT.…”

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confidence: 99%

Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Rajian

Girish

et al. 2012

J. Biomed. Opt

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“…This modality, however, can only demonstrate the time-integrated record of joint damage that tends to develop late in the course of the disease. 4 Therefore, X-ray is of limited value for early diagnosis or therapy monitoring, for which there is an increasing demand in patients treated with today's potent biologics. Even though the majority of patients benefit from biologic therapy, up to onethird has only minor, transient clinical improvement, or experiences no benefit at all.…”

Section: Introductionmentioning

confidence: 99%

“…3 Although RA is serious, potentially crippling and commonly disabling, comprehensive diagnosis and optimized therapies are hindered by lack of cost-efficient and powerful joint imaging technologies that allow quantitative monitoring of therapeutic effects on inflammation. 4 Histopathological studies of rheumatic joints generally show chronic proliferative synovitis with fibrin deposition in and around the synovial membrane and the articular cartilage as the hallmark symptom of RA. Synovitis is characterized by persistent vasodilatation and increased capillary permeability.…”

Section: Introductionmentioning

confidence: 99%

In vivotherapy monitoring of experimental rheumatoid arthritis in rats using near-infrared fluorescence imaging

et al. 2014

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Abstract. An in vivo near-infrared fluorescence (NIRF) imaging technique is described for therapy monitoring of ankle joints affected by collagen-induced arthritis, a model of human rheumatoid arthritis. Arthritis was induced in rats by intradermal injections of collagen and Freund's incomplete adjuvant. For in vivo imaging, the nonspecific NIR dye tetrasulfocyanine (TSC) was used. Prior to and after treatment with a nonsteroidal anti-inflammatory drug, meloxicam, or analgesic drug, tramadol hydrochloride (which served as no-therapy control), normalized fluorescence intensities of each ankle joint were measured. Additionally, each ankle joint was characterized by clinical arthritis scoring and histopathology. Over a 3-week treatment period, a significant difference in disease progression between animals treated with meloxicam and tramadol hydrochloride was detected. A statistically significant improvement in ankle joint pathology from high-or moderate-grade to moderate-or low-grade upon meloxicam therapy, as determined by clinical evaluation, translated into a significant decrease in fluorescence intensity. In contrast, all arthritic joints of the no-therapy control group deteriorated to high-grade arthritis with high-fluorescence intensities in NIRF imaging. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Optical imaging: new tools for arthritis

Cited by 33 publications

References 83 publications

Hyperspectral imaging for detection of arthritis: feasibility and prospects

Hyperspectral imaging for detection of arthritis: feasibility and prospects

Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

In vivotherapy monitoring of experimental rheumatoid arthritis in rats using near-infrared fluorescence imaging

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