Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

Zhang, Wenjia; Liang, Xiaolong; Zhu, Liang; Zhang, Xinyu; Jin, Zhengyu; Du, Yang; Tian, Jie; Xue, Huadan

doi:10.1016/j.ebiom.2022.104040

Cited by 21 publications

(8 citation statements)

References 44 publications

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“…Multimodal imaging assessment may be beneficial for the early detection of PDAC and image-guided tumor therapy. − Orthotopic pancreatic tumor nude mice in vivo were used as models for multimodal imaging. The T1WI MR signal intensity at orthotopic tumor sites showed time-dependence after injection of the active-targeted nanoprobe Plectin1-AuNR-siRNA and passive-targeted nanoprobe AuNR-siRNA, reached a peak at 24 and 12 h, respectively, and then gradually decreased (Figure A).…”

Section: Results and Discussionmentioning

confidence: 99%

Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Guo

Ren

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Pancreatic cancer (PC) is one of the most malignant cancers that develops rapidly and carries a poor prognosis. Synergistic cancer therapy strategy could enhance the clinical efficacy compared to either treatment alone. In this study, gold nanorods (AuNRs) were used as siRNA delivery vehicles to interfere with the oncogenes of KRAS. In addition, AuNRs were one of anisotropic nanomaterials that can absorb near-infrared (NIR) laser and achieve rapid photothermal therapy for malignant cancer cells. Modification of the erythrocyte membrane and antibody Plectin-1 occurred on the surface of the AuNRs, making them a promising target nanocarrier for enhancing antitumor effects. As a result, biomimetic nanoprobes presented advantages in biocompatibility, targeting capability, and drug-loading efficiency. Moreover, excellent antitumor effects have been achieved by synergistic photothermal/gene treatment. Therefore, our study would provide a general strategy to construct a multifunctional biomimetic theranostic multifunctional nanoplatform for preclinical studies of PC.

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Section: Results and Discussionmentioning

confidence: 99%

Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Guo

Ren

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…MRI can provide high-resolution deep tissue morphology and anatomical details and is generally used clinically. When using contrast agents, the sensitivity of MRI is limited [20]. Therefore, developing multimodal imaging techniques that integrate the complementary advantages of different modalities is imperative [21][22][23].…”

Section: Ivyspringmentioning

confidence: 99%

Quantitative visualization of myocardial ischemia-reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging

Yang,

Wang,

et al. 2024

Theranostics

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Myocardial ischemia-reperfusion (MI/R) injury is a complication in vascular reperfusion therapy for MI, occurring in approximately 60% of patients. Ferroptosis is an important process in the development of MI/R cardiac lesions. Transferrin receptor 1 (TfR1), a marker of ferroptosis, corresponds to the changes in MI/R cardiac lesions and is expected to be a biomarker for detecting MI/R-induced ferroptosis. However, the noninvasive in vivo visualization of ferroptosis in MI/R is a big challenge. Thus, this study aimed to develop a novel multimodal imaging platform to identify markers of MI/R cardiac lesions in vivo through targeting TfR1. Methods: Magnetic particle imaging (MPI) modality for ferroptosis based on superparamagnetic cubic-iron oxide nanoparticles (SCIO NPs), named feMPI, has been developed. FeMPI used TfR1 as a typical biomarker. The feMPI probe (SCIO-ICG-CRT-CPPs NPs, CCI NPs) consists of SCIO NPs, TfR1-targeting peptides (CRT), cell-penetrating peptides (CPPs), and indocyanine green (ICG). The specificity and sensitivity of CCI NPs in the MI/R mouse model were evaluated by MPI, magnetic resonance imaging (MRI), and near-infrared (NIR) fluorescent imaging. Results: The intensity of the MPI signal correlates linearly with the percentage of infarct area in MI/R stained by TTC, enabling a quantitative assessment of the extent of cardiac lesions. Notably, these findings are consistent with the standard clinical biochemical indicators in MI/R within the first 24 h. FeMPI detects cardiac injury approximately 48 h prior to the current clinical imaging detection methods of MI/R. Conclusion:The feMPI strategy can be a powerful tool for studying the process of MI/R-induced ferroptosis in vivo, providing clues for molecular imaging and drug development of ferroptosis-related treatments.

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“…At present, the main targets involved are SSTR[ 47 ], urokinase-type plasminogen activator receptor[ 48 ], insulin-like growth factor-1 receptor, αVβ 6 , epidermal growth factor receptor, vascular endothelial growth factor receptor-2[ 49 ], etc ., but their prospect of clinical application requires further study. In addition, targets such as reticulin-1 (plectin-1)[ 50 ], mucin-1[ 51 ], MUC4, carcinoembryonic antigen-related cell adhesion molecule 6[ 52 ], γ-glutamyltransferase 5[ 53 ], P32 protein[ 54 ], mesothelin[ 55 ], thymus fine cell differentiation antigen-1, cathepsin E, neutrophil gelatinase-associated lipid transport protein[ 56 ] were also examined, which could lead to a new imaging target for pancreatic carcinoma.…”

Section: Magnetic Resonance Molecular Imagingmentioning

confidence: 99%

Advancements of molecular imaging and radiomics in pancreatic carcinoma

Pang¹,

Xie²,

Yao³

et al. 2023

World J Radiol

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Despite the recent progress of medical technology in the diagnosis and treatment of tumors, pancreatic carcinoma remains one of the most malignant tumors, with extremely poor prognosis partly due to the difficulty in early and accurate imaging evaluation. This paper focuses on the research progress of magnetic resonance imaging, nuclear medicine molecular imaging and radiomics in the diagnosis of pancreatic carcinoma. We also briefly described the achievements of our team in this field, to facilitate future research and explore new technologies to optimize diagnosis of pancreatic carcinoma.

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Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

Cited by 21 publications

References 44 publications

Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Quantitative visualization of myocardial ischemia-reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging

Advancements of molecular imaging and radiomics in pancreatic carcinoma

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