Organometallic complexes with biological molecules. XVIII. Alkyltin(IV) cephalexinate complexes: synthesis, solid state and solution phase investigations

Antiproliferative and anti-tumor activity of organotin compounds

“…The biological activity of dialkyltin(IV) and trialkyltin(IV) complexes of the deacetoxycephalo-sporin-antibiotic cephalexin [7-(d-2-amino-2-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid] (Hceph) (Scheme 9C) with formulae R 2 Sn(ceph) 2 (R = Me (182), n-Bu (183)) and R 3 Sn(ceph) (R = Me (184), n-Bu (185)) was evaluated [57]. The cytotoxic activity of organotin(IV) cephalexinate derivatives has been tested using two different chromosome-staining techniques Giemsa and CMA 3 , towards spermatocyte chromosomes of the mussel Brachidontes pharaonis (Mollusca: Bivalvia).…”

Chiral self-assembly of methyltin(IV)-naproxenates: Combining dative Sn–O bonds, secondary Sn⋯O interactions and C–H⋯O hydrogen bonding to make an inter-helical meander-shaped network and a cross-linked Z-shaped ribbon

“…These complexes have a tendency to self-assemble into supramolecular structures by dative Sn-O bonds (2.2-2.3 Å ) and SnÁ Á ÁO secondary interactions (>2.5 Å ) [41]. Moreover, the organotin(IV) carboxylates have been one of the most extensively studied class of anticancer compounds since it was observed that they are significantly reduce the growth rates of tumours [42][43][44][45][46]. We selected the (S)-(+)-6-methoxy-a-methyl-2-naphthaleneacetic acid, (S)-naproxen (Hnap), as a potent candidate for the preparation of enantiomerically pure organotin(IV)-complexes.…”

On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3-amino and 4-aminobenzoic acids

“…The above findings are in line with the general considerations of the toxicity of Table 2 Selected bond lengths (Å) and angles (°) for compound 2a0.75benzene. organotin(IV) compounds [43][44]. An analysis of variance (ANO-VA) treatment of the experimental data using the cell line the organotin concentration the tin substituent and the benzoic ring substituent revealed the expected significant difference of all factors both alone and in pairwise treatment except the last one, in line with the established major role of the R 3 Sn + moiety as biocidal agent regardless of the corresponding anion.…”