Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone

Eisenlohr‐Moul, Tory A.; DeWall, C. Nathan; Girdler, Susan S.; Segerstrom, Suzanne C.

doi:10.1016/j.biopsycho.2015.03.016

Cited by 58 publications

(45 citation statements)

References 116 publications

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“…This has also been demonstrated with regard to risky behaviors in women (e.g., borderline personality disorder symptoms; Eisenlohr-Moul et al, 2015; emotional eating; Klump et al, 2013). Yet, these interactive effects of E2 and P4 have not been evaluated in relation to substance abuse and specifically on drinking in humans.…”

mentioning

confidence: 68%

Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Martel¹,

Eisenlohr‐Moul²,

Roberts³

2017

Journal of Abnormal Psychology

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Patterns and features of substance use and abuse vary across the menstrual cycle in humans. Yet, little work has systematically examined the within-person relationships between ovarian hormone changes and alcohol use across the menstrual cycle. Our study was the first to examine the roles of within-person levels and changes in estradiol (E2) and progesterone (P4) in relation to daily alcohol use and binge drinking in young women. Participants were 22 naturally-cycling women, ages 18–22, recruited through a university subject pool who reported any alcohol use and who completed a screening visit assessing study eligibility, followed by 35 subsequent days of data collection. E2 and P4 were obtained via enzyme immunoassay of saliva samples collected by participants each morning, thirty minutes after waking. Presence and degree of daily substance use were obtained using an adaptation of the Timeline FollowBack Interview completed daily. Results indicated that elevated E2 in the context of decreased P4 levels were associated with higher risk of drinking and binge drinking. These effects were present only on weekend days. Results are suggestive of a dual risk model in which both ovulatory E2 increases and perimenstrual P4 decreases increase risk for drinking. Differential associations of steroids with drinking across the menstrual cycle may suggest the need for clinical assessment of substance use to take into account hormone dynamics and menstrual cycle phase.

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mentioning

confidence: 68%

Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Martel¹,

Eisenlohr‐Moul²,

Roberts³

2017

Journal of Abnormal Psychology

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“…Mindfulness skills that increase awareness and acceptance of emotions may help prevent impulsive, aggressive responses to conflicts and stressors, whereas these skills may be less likely to prevent the commission of purposeful acts of violence. Mindfulness-based approaches may also be useful in reducing aggression in disorders characterized by anger rumination, such as borderline personality disorder (Baer & Sauer, 2011; Peters, Geiger, Smart, & Baer, 2014; Eisenlohr-Moul, Girdler, DeWall, & Segerstrom, 2015; Peters et al, under review). …”

Section: Discussionmentioning

confidence: 99%

Both Trait and State Mindfulness Predict Lower Aggressiveness via Anger Rumination: a Multilevel Mediation Analysis

et al. 2016

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Trait mindfulness, or the capacity for nonjudgmental, present-centered attention, predicts lower aggression in cross-sectional samples, an effect mediated by reduced anger rumination. Experimental work also implicates state mindfulness (i.e., fluctuations around one's typical mindfulness) in aggression. Despite evidence that both trait and state mindfulness predict lower aggression, their relative impact and their mechanisms remain unclear. Higher trait mindfulness and state increases in mindfulness facets may reduce aggression-related outcomes by (1) limiting the intensity of anger, or (2) limiting rumination on anger experiences. The present study tests two hypotheses: First, that both trait and state mindfulness contribute unique variance to lower aggressiveness, and second, that the impact of both trait and state mindfulness on aggressiveness will be uniquely partially mediated by both anger intensity and anger rumination. 86 participants completed trait measures of mindfulness, anger intensity, and anger rumination, then completed diaries for 35 days assessing mindfulness, anger intensity, anger rumination, anger expression, and self-reported and behavioral aggressiveness. Using multilevel zero-inflated regression, we examined unique contributions of trait and state mindfulness facets to daily anger expression and aggressiveness. We also examined the mediating roles of anger intensity and anger rumination at both trait and state levels. Mindfulness facets predicted anger expression and aggressiveness indirectly through anger rumination after controlling for indirect pathways through anger intensity. Individuals with high or fluctuating aggression may benefit from mindfulness training to reduce both intensity of and rumination on anger.

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“…Therefore, higher values of E2 CWP and P4 CWP reflect currently increased levels relative to one's own person means 1 (Singer and Willett, 2003; see Eisenlohr-Moul et al, 2015 for visual depiction of method).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, those with MRMD and histories of abuse show unique alterations in various stress-responsive physiological systems that are not seen in women without a MRMD who have similar abuse histories, including the hypothalamic-pituitary-thyroid axis (Girdler et al, 2004; Bunevicius et al, 2012) and the sympathetic nervous system (Girdler, 2003; Girdler et al, 2007). Finally, we recently found that cyclical increases in P4 were associated with greater susceptibility to mood symptoms and interpersonal problems only among women high in borderline personality features (Eisenlohr-Moul et al., 2015), traits which often develop as adaptations to abuse (Bandelow et al, 2005). …”

Section: Introductionmentioning

confidence: 99%

Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder

Eisenlohr‐Moul

Rubinow

Schiller

et al. 2016

Psychoneuroendocrinology

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Objective Individual differences in sensitivity to cyclical changes in ovarian steroids estradiol (E2) and progesterone (P4) have been implicated in the pathophysiology of menstrually related mood disorder (MRMD). However, no prospective studies have investigated psychosocial risk factors for sensitivity to hormone effects on mood in MRMD. Using a repeated measures approach and multilevel models, we tested the hypothesis that a history of abuse provides a context in which within-person elevations of E2 and P4 prospectively predict daily symptoms. Method 66 women with prospectively-confirmed MRMD recruited for a trial of oral contraceptives provided 1 month of baseline hormone and mood data prior to randomization. Lifetime physical and sexual abuse experiences were assessed. Across one cycle, women completed daily measures of symptoms and provided blood samples on 5 days across the menstrual cycle. Current E2 and P4 were centered within person (CWP) such that higher values represented cyclical elevations in hormones. Results Rates of physical (27%) and sexual (29%) abuse were high, consistent with previous work documenting a link between trauma and MRMD. In women with a history of physical abuse, cyclical increases in P4 predicted greater mood and interpersonal symptoms on the three days following that sample. In women with a history of sexual abuse, cyclical increases in E2 predicted greater anxiety symptoms on the three days following that sample. Conclusions Results inform further inquiry into the role of severe life stressors and stress response systems in MRMD. We discuss areas for future research on the psychosocial and physiological pathways through which abuse may influence the link between hormones and symptoms.

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Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone

Cited by 58 publications

References 116 publications

Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Both Trait and State Mindfulness Predict Lower Aggressiveness via Anger Rumination: a Multilevel Mediation Analysis

Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder

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