Oxidative Stress and Anxiety: Relationship and Cellular Pathways

Bouayed, Jaouad; Rammal, Hassan; Soulimani, Rachid

doi:10.4161/oxim.2.2.7944

Cited by 414 publications

(317 citation statements)

References 48 publications

(98 reference statements)

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“…Oxidative damage is an established outcome of stress that has been implicated in the pathogenesis of mood and anxiety disorders. 4 Anti-stress drugs are widely used for the treatment of stress. Selective serotonin reuptake inhibitors (SSRIs) are the major and dominant class of antidepressants used over the last decade whereas ancient groups of most widely used antidepressants were Tricyclic antidepressants (TCA) and monoamine oxidase inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Effect of Anti-stress Activity of Fluoxetine on Restrained Stress Induced Male Albino Rats in Hematological Parameters and Whole Brain Histopathology

Kori¹,

Aladkatti²,

Desai³

et al. 2017

JYP

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Objective: In this study we investigated the effect of Fluoxetine, a selective serotonin reuptake inhibitor, on the gravimetry, hematology and whole brain histopathology in the restrained stressed male albino rats. Methodology: Adult male Wistar albino rats weighing about 175-225 g were taken for the study and were divided into four groups of six animals each. Group I (control), Group II (stress induced), Group III (stress + withdrawal) and Group IV (stress + Fluoxetine, 20 mg/kg body weight, i.p.). The gravimetrical parameters, hematological parameters and whole brain histopathology of all the experimental rats were evaluated. Results: After 42 days of restraint stress, there was a significant (P ≤0.05) decrease final body weight, whole brain weight, Hb, RBC, MCV, MCH, total WBC and Platelets, whereas increase in Neutrophils, lymphocytes, eosinophils and monocytes in Group II of restraint stress rats when compared with their control group I. The stress withdrawal group (Group III) and drug Fluoxetine treatment (Group IV) shown significantly (P≤0.05) improvement in gravimetry, hematological parameters and whole brain histopathology in restraint stress compared to only stress induced group II. Conclusion: The drug Fluoxetine treatment could exert a protective effect on restrained stress induced alterations in gravimetrical parameters, hematological parameters and whole brain histopathology of male albino rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Anti-stress Activity of Fluoxetine on Restrained Stress Induced Male Albino Rats in Hematological Parameters and Whole Brain Histopathology

Kori¹,

Aladkatti²,

Desai³

et al. 2017

JYP

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show abstract

“…6 Antioxidant therapy has been reported to have a protective effect in anxiety disorders. Polyphenols, flavonoids, specific foods and diets rich in antioxidants have been shown to improve antioxidant status and have anxiolytic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress has also been implicated in depression and anxiety disorders. 6 Studies have revealed that antioxidants have a key role as an adju-vant therapy in patients with generalized anxiety disorder and depression. 7 Flavonoids are reported to be potent antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals

Kaur¹,

Shri²,

Kamboj³

2017

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Introduction:Oxidative stress in the brain causes nervous system impairment. Hence the use of antioxidants could be an effective approach to prevent disorders such as anxiety. Plants containing phenolic constituents are reported to be potent antioxidants. Brassica oleracea L. commonly known as broccoli, is rich in phenolics mainly flavonoids and possesses excellent antioxidant property, however its anxiolytic potential has not been investigated. Thus in the present study antianxiety activity of extracts of broccoli was evaluated in experimental animals. Materials and Methods: Various pharmacognostic parameters of the plant material were studied following standard procedures. Groups of six mice each were taken as different treatment groups. Control group received vehicle (1% Carboxy Methyl Cellulose), positive control received Diazepam (2mg/kg) as standard drug while test groups received petroleum ether and hydroalcoholic extracts (50, 100 and 200 mg/kg body weight, p.o.). The effects were evaluated on Elevated Plus Maze (EPM), hole board and mirror chamber tests. Statistical analysis was performed using ANOVA, followed by Turkey's post-hoc test. Results: Hydroalcoholic extract shows dose dependent increase in the average time spent and frequency of entries in the open arms of the EPM; decreased latency, increased time spent and frequency of entries in the mirror chamber; increased number of head dips in hole board test as compared to control was observed. These effects were comparable to the effect produced by diazepam. Phytochemical screening of the bioactive extract revealed the presence of alkaloids, phenols, flavonoids and tannins. Conclusion: From our study, it can be concluded that hydroalcoholic extract of Brassica oleracea at the dose of 200 mg/kg possesses marked anxiolytic activity.

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“…13 The harmful effects of stress in the body and, in particular, oxidative stress range from asthma, obesity, diabetes, depression and anxiety, Alzheimer's disease, and so on. [14][15][16][17] In the oral cavity, the effects range from periodontitis, recurrent aphthous ulcers, myofunctional pain dysfunction syndrome, atypical orofacial pain to even lichen planus, oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Total Antioxidant Capacity of Saliva: An Effective Marker of Stress

2017

Journal of Contemporary Dentistry

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Aim: To assess and correlate the level of stress to the total anti oxidant capacity of saliva of university examgoing students study ing at KLE Vishwanath Katti Institute of Dental Sciences, Belagavi, Karnataka, India, on the day of examination (stressed condition) and in the postexamination period (nonstressed condition). Materials and methods:Saliva samples of 30 students evaluated by the perceived stress scale on both the day of examination and in the postexamination period were col lected and labeled as group I (day of examination) and group II (postexamination period). The total antioxidant capacity was assessed using the spectrophotometric assay based on the molar absorption coefficient of the phosphomolybdenum complex. The correlation between the level of stress and the antioxidant capacity was done using Spearman's correlation test, and the mean values obtained with respect to the two groups were evaluated using Mann-Whitney U test. Results:The total antioxidant capacity was lower on the day of examination than in the postexamination period (p = 0.001). As the stress level increases, the total antioxidant capacity decreases. Conclusion:Total antioxidant capacity of saliva can serve as an effective marker of stress. Thus, supplementation with antioxidants routinely and especially during periods of stress may be beneficial.Clinical significance: Present day life is full of targets, neces sities, and frustrations. For many people, stress has become a way of life. Stress is not always detrimental. Stress within your comfort zone helps you compete, motivates you, and can even keep you secure. But when stress becomes overwhelming, it damages your wellbeing, relationships, and quality of life. Thus, managing and diagnosing stress is important.

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Oxidative Stress and Anxiety: Relationship and Cellular Pathways

Cited by 414 publications

References 48 publications

Effect of Anti-stress Activity of Fluoxetine on Restrained Stress Induced Male Albino Rats in Hematological Parameters and Whole Brain Histopathology

Effect of Anti-stress Activity of Fluoxetine on Restrained Stress Induced Male Albino Rats in Hematological Parameters and Whole Brain Histopathology

Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals

Total Antioxidant Capacity of Saliva: An Effective Marker of Stress

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