Oxygen Tension Measurements of Head and Neck Cancers

Terris, David J.; Dunphy, Eamonn P.

doi:10.1001/archotol.1994.01880270031006

Cited by 46 publications

(28 citation statements)

References 11 publications

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“…This result was also observed in our previous spectroscopy study of HNCC [16]. In another study, Terris and Dunphy found that the pO 2 of the primary tumor (22.7 ± 16.0 mm Hg) was lower than that of normal subcutaneous tissue (57.2 ± 12.8 mm Hg) [46]. This result is concordant with our findings.…”

Section: Discussionsupporting

confidence: 93%

Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma

Vishwanath

Beumer

et al. 2014

Oral Oncology

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SUMMARY Objectives We propose the use of morphological optical biomarkers for rapid detection of human head and neck squamous cell carcinoma (HNSCC) by leveraging the underlying tissue characteristics in aerodigestive tracts. Materials and Methods Diffuse reflectance spectra were obtained from malignant and contra-lateral normal tissues of 57 patients undergoing panendoscopy and biopsy. Oxygen saturation, total hemoglobin concentration, and the reduced scattering coefficient were extracted. Differences in malignant and normal tissues were examined based on two different groupings: anatomical site and morphological tissue type. Results and Conclusions Measurements were acquired from 252 sites, of which 51 were pathologically classified as SCC. Optical biomarkers exhibited statistical differences between malignant and normal samples. Contrast was enhanced when parsing tissues by morphological classification rather than anatomical subtype for unpaired comparisons. Corresponding linear discriminant models using multiple optical biomarkers showed improved predictive ability when accounting for morphological classification, particularly in node-positive lesions. The false-positive rate was retrospectively found to decrease by 34.2% in morphologically- vs. anatomically-derived predictive models. In glottic tissue, the surgeon exhibited a false-positive rate of 45.7% while the device showed a lower false-positive rate of 12.4%. Additionally, comparisons of optical parameters were made to further understand the physiology of tumor staging and potential causes of high surgeon false-positive rates. Optical spectroscopy is a user-friendly, non-invasive tool capable of providing quantitative information to discriminate malignant from normal head and neck tissues. Predictive models demonstrated promising results for real-time diagnostics. Furthermore, the strategy described appears to be well suited to reduce the clinical false-positive rate.

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Section: Discussionsupporting

confidence: 93%

Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma

Vishwanath

Beumer

et al. 2014

Oral Oncology

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“…The brain tumor study had sufficient homogeneity to resolve a doublet resonance at 1.3 ppm. While magnetic field homogeneity across the neck node was not adequate to resolve the lactate doublet, measurements of tissue oxygenation using an Eppendorf polargraphic oxygen electrode (Kimoc, Hamburg, FRG) yielded a median pO 2 value of 0.7 mm Hg, which is highly suggestive of hypoxia (64).…”

Section: Discussionmentioning

confidence: 99%

In VivoLactate Editing with Simultaneous Detection of Choline, Creatine, NAA, and Lipid Singlets at 1.5 T Using PRESS Excitation with Applications to the Study of Brain and Head and Neck Tumors

Star‐Lack

Spielman

Adalsteinsson

et al. 1998

Journal of Magnetic Resonance

101

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“…Oxygen Tension Measurement. All measurements were performed using a computerized histograph (Sigma Eppendorf pO2 Histograph, Hamburg, Germany) as described previously (20). Fifty to eighty pO2 measurements in two to three tracks were recorded from each tumor, and an equal number of measurements was taken from normal subcutaneous tissues.…”

Section: Methodsmentioning

confidence: 99%

Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling

et al. 2004

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Hypoxia within solid tumors decreases therapeutic efficacy, and identification of hypoxia markers may influence the choice of therapeutic modality. Here, we used a proteomic approach to identify hypoxia-regulated proteins and validated their use as endogenous indicators of tumor hypoxia. Using two-dimensional gel electrophoresis and PowerBlot (antibody-based array), we identified a group of 20 proteins that are increased >1.5-fold during hypoxia. The majority of these proteins such as IB kinase ␤ (IKK␤), MKK3b, highly expressed in cancer (HEC), density-regulated protein 1, P150 glued , nuclear transport factor 2, binder of ARL 2, Paxillin, and transcription termination factor I have not been previously reported to be hypoxia inducible. The increase in these proteins under hypoxia was mediated through posttranscriptional mechanisms. We additionally characterized the role of IKK␤, a regulator of the nuclear factor-B transcription factor, during hypoxia. We demonstrated that IKK␤ mediates cell survival during hypoxia and is induced in a variety of squamous cell carcinoma cell lines. Furthermore, we showed that IKK␤ expression from tumor specimens correlated with tumor oxygenation in patients with head and neck squamous cell carcinomas. These data suggest that IKK␤ is a novel endogenous marker of tumor hypoxia and may represent a new target for anticancer therapy.

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Oxygen Tension Measurements of Head and Neck Cancers

Cited by 46 publications

References 11 publications

Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma

Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma

In VivoLactate Editing with Simultaneous Detection of Choline, Creatine, NAA, and Lipid Singlets at 1.5 T Using PRESS Excitation with Applications to the Study of Brain and Head and Neck Tumors

Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling

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