Paget Disease of the Breast

Jimenez, Rafael E.; Hieken, Tina J.; Peters, Margot S.; Visscher, Daniel W.

doi:10.1016/b978-0-323-35955-9.00012-x

Cited by 4 publications

(5 citation statements)

References 107 publications

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“… 9 Differential diagnoses include basal cell carcinoma, melanoma, sebaceous carcinoma, allergic eczema, mastitis, candidiasis and tinea corporis. 12 …”

Section: Discussionmentioning

confidence: 99%

“…9 Differential diagnoses include basal cell carcinoma, melanoma, sebaceous carcinoma, allergic eczema, mastitis, candidiasis and tinea corporis. 12 There are two proposed theories for the origin of PDB. One is the epidermotropic theory that describes the migration of ductal cancer cells along the basement membrane due to the expression of HER-2 and an association of a breast lump.…”

Section: Discussionmentioning

confidence: 99%

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Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Lodhia

Urassa

Mremi

2023

SAGE Open Medical Case Reports

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Paget’s disease of the breast is a rare pathology resulting from abnormal proliferation of glandular epithelial cells in the nipple–areolar epidermis. The disease is named after James Paget, a pathologist and surgeon, who reported a relationship between a nipple rash and mammary gland tumors in 1874. Early diagnosis may be quite difficult. Histopathology can give the definitive diagnosis and the treatment depends upon the presence or absence of an associated breast lump. The treatment options include simple lumpectomy, mastectomy or radical mastectomy depending upon the lump (cancer) in the diseased breast. Herein, we present a case of Paget’s disease of the breast presented with a long history of nipple eczema.

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“… 9 Differential diagnoses include basal cell carcinoma, melanoma, sebaceous carcinoma, allergic eczema, mastitis, candidiasis and tinea corporis. 12 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Lodhia

Urassa

Mremi

2023

SAGE Open Medical Case Reports

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“…Paget's disease is characterized by infiltration of the nipple and areolar epidermis by large tumor cells of glandular differentiation [ 9 ]. It accounts for 1.45% of all male breast malignancy and 0.68% of all female breast malignancies [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for 1.45% of all male breast malignancy and 0.68% of all female breast malignancies [ 10 ]. The underlying malignancy is usually of ductal type and has a high histologic grade [ 9 ]. The incidence of PD without an underlying malignancy is more prominent in males [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Paget's disease of the breast in male with underlying invasive ductal carcinoma: A case report with review of literature

Salih

Hammood²,

Kakamad

et al. 2021

Annals of Medicine and Surgery

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“…These lesions were characterized by an eczematous eruption of the nipple–areola complex (NAC) occurring approximately one to two years prior to mammary gland cancer [ 1 ]. However, the histopathology of the disease was not fully understood until 30 years later, when H. C. Jacobaeus suggested that, in PD, cancer cells actually originating from an preexisting neoplasm invade the epidermis of the nipple [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Extramammary Paget’s Disease of the Vulva: Report of Two Cases

et al. 2021

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Extramammary Paget’s disease is a rare condition, affecting 6.5% of all patients with Paget’s disease. The most common extramammary site is the vulvar area. Although diagnosis in some patients is difficult to set, early diagnosis is of high importance in order to detect the irreversible progression of the lesion early and prevent distant metastasis. An 89-year-old female and a 69-year-old female presented within three months with an eczematous lesion with leukoplakia in the vulva. The incisional biopsy of the skin revealed extramammary Paget’s disease. Both patients underwent a surgical wide local excision of the lesion and the specimens were sent for histopathological examination. Extramammary Paget’s disease has a high potential for distant malignancies and local recurrence, dictating that surgical excision is the most efficient treatment. The rareness of the condition and the diagnostic difficulties underline the need for early skin biopsy, which is the most efficient diagnostic tool.

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Paget Disease of the Breast

Cited by 4 publications

References 107 publications

Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Paget's disease of the breast in male with underlying invasive ductal carcinoma: A case report with review of literature

Extramammary Paget’s Disease of the Vulva: Report of Two Cases

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