Palatal myoclonus: Treatment with 5‐hydroxytryptophan and carbidopa

Bhatt, Mohit; Snow, Barry; Varelas, Michael; Calne, Donald B.

doi:10.1002/mds.870050419

Cited by 4 publications

(3 citation statements)

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“…The treatment of PM is variable, with better results in those with PPM [1][2][3]5,6,[10][11][12][13][14] . In all patients it should be carried a trial with sumatriptan, even those with possible secondary PM, to differentiate clinically the PPM from SPM 4,10,15 .…”

Section: Fig 2 Electromyography (Sumatriptan In the Case 1)mentioning

confidence: 99%

“…The most common reports of treatment of PM are with the use of clonazepan, anticholinergics drugs, 5-hydroxytryptophan, levodopa, baclofen, piracetan and anticonvulsant drugs [1][2][3]5,6,[10][11][12][13][14][15] . There is a report of PM following Behçet's disease ameliorated by ceruletide (a potent analogue of CCK octapeptide) 14 .…”

Section: Fig 2 Electromyography (Sumatriptan In the Case 1)mentioning

confidence: 99%

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Palatal myoclonus: report of two cases

Fabiani

Teive

Sá

et al. 2000

Arq. Neuro-Psiquiatr.

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-We describe two cases of palatal myoclonus (PM), one essential and another secondary to a stroke. Case 1: a 64 years old female who developed clicking sounds in both ears after a stroke and three years later on noticed a progressive involuntary movement of the throat associated with rhythmic contractions of the soft palate, muscles of tongue and throat. MRI showed an ischemic area in brainstem. The patient had a partial response to the use of sumatriptan 6 mg subcutaneously. Case 2: a 66 years old female who began with ear clicking at left ear that worsed slowly associated with tinnitus and arrhythmic movements of soft palate and an audible click at left ear. Brain MRI was normal; audiometry showed bilateral neurosensory loss. She was prescribed clonazepan 1 mg daily with complete recovery. Primary and secondary palatal myoclonus share the same clinical features but probably have different pathophysiological underlying mechanisms.KEY WORDS: palatal myoclonus, sumatriptan, clonazepan. Mioclonia palatal: relato de dois casosRESUMO -Descrevemos dois casos de mioclonia palatal (MP), um essencial e o outro secundário a acidente vascular cerebral (AVC). Caso1: mulher de 64 anos que desenvolveu cliques audíveis em ambos os ouvidos após um AVC e que três anos depois começou a apresentar movimentos involuntários do pálato, músculos do língua e garganta. A ressonância magnética (RNM) mostrou áreas de isquemia no tronco cerebral. A paciente apresentou resposta parcial e não duradoura ao uso subcutâneo de 6 mg de sumatriptano. Caso 2: mulher de 66 anos, com cliques audíveis no ouvido esquerdo que pioraram progressiva e lentamente associados com tinitus e movimentos mais ou menos rítmicos do pálato mole. A RNM encefálica era normal. A audiometria mostrou perda neurossensorial bilateral. Foi medicada com 1,0 mg de clonazepan diariamente com completa recuperação. MP primária e secundária compartilham das mesmas características clínicas, mas evidências sugerem que se devam a diferentes mecanismos fisiopatológicos. PALAVRAS-CHAVE: mioclonia palatal, sumatriptano, clonazepan.Palatal myoclonus (PM) is a form of segmental myoclonus. It is an uncommon, rhythmic, "shock-like" involuntary movement of the muscles of soft palate, throat and other structures derived from the branchial arcs 1-3 . Some authors prefer to call it palatal tremor 3 . Jankovic suggests that the most correct term shall be PM 4 . Although it is a rare condition , it is well established that the anatomic structures involved in the process are almost always in the inferior olivary nucleus -that show an hypertrophic degeneration [1][2][3]5,6 .

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Section: Fig 2 Electromyography (Sumatriptan In the Case 1)mentioning

confidence: 99%

Section: Fig 2 Electromyography (Sumatriptan In the Case 1)mentioning

confidence: 99%

Palatal myoclonus: report of two cases

Fabiani

Teive

Sá

et al. 2000

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Palatal tremor (PT) is a movement disorder involving rhythmic posterior movement of the soft palate and uvula and anterior movement of the pharynx, often associated with a clicking sound because of closure of the eustachian tube. There are reports of successful treatment of PT with 5-hydroxytryptophan and carbidopa (2).…”

Section: Introductionmentioning

confidence: 99%