Papaya Seed Extract Lowers Sperm Concentrations, Motility  and Viability in Male Mice

Wiryawan, Reryd Arindany; I’tishom, Reny; Purwaningsih, Sri

doi:10.20473/fmi.v51i4.2855

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study are in accordance with previous research conducted by Wiryawan et al (2016) that there was a decrease in the concentration of spermatozoa in mice given papaya seed extract orally. This is predicted because the alkaloid content is estrogenic which results in a decrease in the hormone testosterone by inhibiting the gonadotropin glands (GnRH) to inhibit LH and FSH secretion in the anterior pituitary.…”

Section: Discussionsupporting

confidence: 93%

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

Mahayani¹,

Satriyasa²,

Widianti³

2022

kedokteran

View full text Add to dashboard Cite

Increasing population is one of the problems faced in Indonesia. Men's participation and knowledge of contraception is still lacking. Papaya leaves are thought to have an antifertility effect due to the content of secondary metabolites, namely flavonoids, alkaloids, saponins, tannins and papain enzymes that have estrogenic effects that can interfere with hormone regulation in the hypothalamic-pituitary-gonadal axis. This study used an experimental study with a post-test only control group design. The samples used were Swiss Webster strain male mice (Mus musculus) aged 2-3 months with a body weight of 20-30 grams as many as 36 mice divided into 2 groups. The control group (P0) was given 0.5 ml of 3% Tween and the treatment group (P1) was given 0.21 mg/gram BW ethanol extract of papaya leaves (Carica papaya L.) for 36 days orally. The data obtained were analyzed using the Independent Sample T-test. This study showed the results: (1) the average concentration of spermatozoa in the control group (107.6 million/ml) was higher than the treatment group (83.0 million/ml) with p=0.000; (2) the mean of rapidly progressive spermatozoa motility in the control group (41.0 µm/sec) was higher than the treatment group (19.0 µm/sec) with p= 0.000; (3) the average viability of spermatozoa in the control group (87.7%) was higher than the treatment group (71.9%) with p=0.000; (4) the normal morphological mean of the spermatozoa treatment group (81.6%) was higher than the normal morphological mean of the treatment group (38.1%) with p=0.000. Keywords: Male Contraception; Papaya Leaf Extract; Spermatozoa Quality.

show abstract

Section: Discussionsupporting

confidence: 93%

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

Mahayani¹,

Satriyasa²,

Widianti³

2022

kedokteran

View full text Add to dashboard Cite

show abstract

“…2,3 Extract of papaya seed showed an antifertility effect in mice by lowering sperm concentration, motility, and viability. 4,5 Extract of Stelechocarpus burahol also has an antifertility effect in male mice 6 . Ethanol extract of Dalbergia sissoo Roxb stem bark has anti-spermatogenic activity, 7 Taraxacum officinale also has anti-spermatogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Antifertility effect of betel nut (Areca catechu L) in male rat

Rahman

Purwakanthi²,

Dewi³

2020

medisians

View full text Add to dashboard Cite

Background: Betel nut (Areca catechu L) are traditional beverages in Jambi. Betel nut high dose has a cytotoxic effect on testis and other organs—limited data about the effect of betel nut as male antifertility.Purposes: This study aimed to determine the effect of infertility on betel nut use at a dose of 50 mg/kg body weight (BW) in male rats. Methods: Ten male Sprague Dawney rats that had passed the fertility test, aged 2-3 months and weighing 150-200 grams ware used in this study. The rat was grouped into two groups randomly. Group 1, as the negative control, were received aqua dest, and group 2 was treated by betel nut with dose 50 mg/kg BW for 35 days. When terminated, testis weight weighed using micro scales. Blood collected for measuring testosterone levels. Histopathology assessment of testis used Hematoxylin Eosin Staining and sperm counting from cauda epididymis.Results: The weight of testis in the group received betel nut was lower than the control group. The histopathology of testis showed shrunk, reduced the diameter of seminiferous tubules, and like cytolytic lesions in the germinal layer—the total sperm number and progressive sperms also lower than the control group (p<0.05). There was no abnormality in Leydig cell and interstitium tissue. Male rats after treatment could not impregnate the female rats.Conclusion: Betel nut at dose 50 mg/kg BW have antifertility activity in male rats.

show abstract

“…Sertoli cells mediate the process of spermiation, namely the cytoplasm is released from the spermatids and mature sperm is released into the lumen of the seminiferous tubules, this process is also influenced by endocrine hormone regulation. This alkaloid content can interfere with this process because it is estrogenic which can interfere with the spermiogenesis process (Wiryawan et al 2016). Based on the above review, it can be concluded that the ethanol extract of papaya leaves (Carica papaya L.) can affect the histopathological picture of the testicles of young adult mice (Mus musculus).…”

Section: Discussionmentioning

confidence: 99%

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Mahayani

Rusmiatik

2022

ijhs

View full text Add to dashboard Cite

The development of contraceptive methods is more focused on female contraception than men is still lacking. Papaya leaves are thought to have an antifertility effect due to the content of secondary metabolites, namely flavonoids, alkaloids, saponins, tannins and papain enzymes that have estrogenic effects that can disrupt hormone regulation in the hypothalamic-pituitary-gonadal axis. This study aimed to prove the administration of ethanol extract of papaya leaves (Carica papaya L.) on the histopathological features of the testicles of young adult mice (Mus musculus). Subjects and Method: This research uses an experimental study with a post-test only control group design. The samples used were male Swiss Webster strain mice (Mus musculus) 2-3 months old with a bodyweight of 20-30 grams as many as 36 individuals were divided into 2 groups. The control group (P0) was given 0.5 ml of Tween 3% and the treatment group (P1) was given ethanol extract of Papaya Leaf (Carica papaya L.) 0.21 mg/gram BW as much as 0.5 ml for 36 days orally. The data obtained were analyzed using the Independent Sample T-test. Result: A total of 11 articles from Asia continent (India, Bangladesh, Philipina, and Nepal).

show abstract

Papaya Seed Extract Lowers Sperm Concentrations, Motility and Viability in Male Mice

Abstract: ABSTRAKIndonesia adalah negara berkembang dengan penduduk padat, sehingga pemerintah menjalankan program KB (Keluarga Berencana)

Cited by 6 publications

References 0 publications

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

ADMINISTRATION OF PAPAYA LEAF (Carica papaya L.) ETHANOL EXTRACT TO YOUNG ADULT MICE (Mus musculus) LEADS TO LOWER SPERMATOZOA QUALITY THAN CONTROLS

Antifertility effect of betel nut (Areca catechu L) in male rat

Papaya leaf (Carica papaya L.) ethanol extract to the histopathological description of the testimony in in the house mouse (Mus Musculus)

Contact Info

Product

Resources

About