Paper-based in vitro tissue chip for delivering programmed mechanical stimuli of local compression and shear flow

Kaarj, Kattika; Madias, Marianne; Akarapipad, Patarajarin; Cho, Soohee; Yoon, Jeong Yeol

doi:10.1186/s13036-020-00242-5

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…An example is the field of microfabrication where techniques such as micropatterning and microfluidics have become much more widely available in the past decade. Another example is the advent of DIY technologies such as Lego-based stretchers 299 or paper-based compressionflow devices 300 . As a result, mechanical platforms can be more readily adapted to investigate particular diseases, as illustrated by a recent study modeling atherosclerosis on a chip 60 .…”

Section: Discussionmentioning

confidence: 99%

Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

et al. 2021

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Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses that regulate their structure and function in health and disease. Here, we review EC responses to substrate-derived biophysical cues, namely topography, curvature, and stiffness, as well as to flow-derived stresses, notably shear stress, pressure, and tensile stresses. Because these mechanical cues in vivo are coupled and are exerted simultaneously on ECs, we also review the effects of multiple cues and describe burgeoning in vitro approaches for elucidating how ECs integrate and interpret various mechanical stimuli. We conclude by highlighting key open questions and upcoming challenges in the field of EC mechanobiology.

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Section: Discussionmentioning

confidence: 99%

Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

et al. 2021

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“…Organ-on-a-chip (OOC) devices mimic human organs, which can be used for many different applications, including drug tests (efficacy and toxicity) [1][2][3][4][5], environmental toxicology [6,7], disease models [8], stem cell differentiation, carcinogenesis [9], etc. [10].…”

Section: Introductionmentioning

confidence: 99%

Microscopic Imaging Methods for Organ-on-a-Chip Platforms

Buchanan

Yoon

2022

Micromachines

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Microscopic imaging is essential and the most popular method for in situ monitoring and evaluating the outcome of various organ-on-a-chip (OOC) platforms, including the number and morphology of mammalian cells, gene expression, protein secretions, etc. This review presents an overview of how various imaging methods can be used to image organ-on-a-chip platforms, including transillumination imaging (including brightfield, phase-contrast, and holographic optofluidic imaging), fluorescence imaging (including confocal fluorescence and light-sheet fluorescence imaging), and smartphone-based imaging (including microscope attachment-based, quantitative phase, and lens-free imaging). While various microscopic imaging methods have been demonstrated for conventional microfluidic devices, a relatively small number of microscopic imaging methods have been demonstrated for OOC platforms. Some methods have rarely been used to image OOCs. Specific requirements for imaging OOCs will be discussed in comparison to the conventional microfluidic devices and future directions will be introduced in this review.

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Organ-on-a-Chip

Yoon

2021

Tissue Engineering

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Paper-based in vitro tissue chip for delivering programmed mechanical stimuli of local compression and shear flow

Cited by 5 publications

References 39 publications

Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology

Microscopic Imaging Methods for Organ-on-a-Chip Platforms

Organ-on-a-Chip

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