Partial liquid ventilation (PLV) and lung injury: Is PLV able to modify pulmonary vascular resistance?

Aly, Hany; Lueders, Meno; Weiswasser, Jonathan M.; Parravicini, Elvira; DeKlerk, Alan; Stolar, Charles J.H.

doi:10.1016/s0022-3468(97)90178-0

Cited by 16 publications

(11 citation statements)

References 15 publications

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“…PVR increased transiently at the beginning of TLV and recovered quickly thereafter in this experiment, which was consistent with the previous study demonstrating that partial liquid ventilation abated the elevation of PVR in oleic acid-injured lungs (12). We speculated that the increase in PVR might be counteracted by the beneficial effects of TLV such as recruitment of atelectatic alveoli, pulmonary blood flow redistribution, and anti-inflammatory effects (7,13).…”

Section: Discussionsupporting

confidence: 92%

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Jiang

et al. 2011

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Total liquid ventilation (TLV) is a promising treatment for severe lung injury and heart resuscitation. We aim to investigate the hemodynamic effect of TLV in piglets with preexisting cardiac dysfunction. After onset of cardiopulmonary dysfunction induced by cardiopulmonary bypass (CPB), piglets were randomly treated with TLV (n = 6) or conventional gas ventilation (n = 6) for 240 min. Hemodynamics was monitored before and at a 30-min interval after CPB. CPB with cardiac arrest resulted in significant decrease in cardiac index (CI) (96.19 ± 6.74 vs. 48.58 ± 3.96 mL/min/kg, P < 0.001) and increase of pulmonary vascular resistance (PVR) (1123.38 ± 198.97 vs. 8180.62 ± 1041.35 dyne·s/cm(5), P < 0.001). Compared with conventional gas ventilation, there was no further significant decrease of CI or increase of PVR during TLV throughout the experiment. No significant difference was observed on other hemodynamic variables including heart rate, mean arterial pressure, mean pulmonary arterial pressure, and central venous pressure between both groups. The fluctuation of mean arterial blood pressure was 3.95 ± 1.68 mm Hg during TLV. No evidence of fluorothorax or cardiac tamponade was observed in either group. We conclude that TLV does not further impair hemodynamics in piglets with preexisting cardiac dysfunction immediately after CPB.

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Section: Discussionsupporting

confidence: 92%

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Jiang

et al. 2011

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“…142 In vitro study of the isolated perfused neonatal piglet injured lung model demonstrated that PLV reduced or prevented an increase in PVR. 143 These studies suggest that improved gas exchange during PLV is related to enhanced mechanical stability of the lung, which may preserve pulmonary blood flow rather than alter central hemodynamics.…”

Section: Preclinical Studiesmentioning

confidence: 94%

Liquid-assisted ventilation: An alternative respiratory modality

1998

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“…pulmonar que esse método melhora a troca gasosa, aumenta a complacência pulmonar e não possui efeito na resistência vascular pulmonar (51,52) ou alterações no débi-to cardíaco (53) . A VLP, quando comparada com ventilação convencional, apresenta impacto positivo na sobrevida e melhora da arquitetura pulmonar, com redução das alterações histológicas e morfológicas em modelos de lesão pulmonar aguda (54,55) .…”

Section: J Pneumol 28(6) -Nov-dez De 2002unclassified

Ventilação líquida: revisão da literatura

2002

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Atualmente, novas alternativas de ventilação têm sido estudadas em quadros de insuficiência respiratória, com o objetivo de melhorar a oxigenação e minimizar a agressão ao parênquima pulmonar. A utilização de perfluorocarbonos líquidos administrados diretamente na via aérea vem sendo ostensivamente estudada em modelos de lesão pulmonar e em alguns ensaios clínicos, demonstrando bons resultados com relação à troca gasosa, mecânica ventilatória e propriedades antiinflamatórias. Os PFCs são substâncias que possuem baixa tensão superficial, alta densidade, são insolúveis em água, além de permitirem alta difusão de oxigênio e gás carbônico. Esses compostos atuam recrutando alvéolos colapsados, melhorando a oxigenação, protegendo a arquitetura pulmonar e atuando como carreadores de impurezas, limpando a superfície alveolar de resíduos da degradação celular. Neste artigo de revisão são apresentadas as diferentes modalidades ventilatórias com perfluorocarbonos e fornecidas informações sobre a utilização e o estado atual da ventilação líquida. (J Pneumol 2002;28(6):351-61)

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Partial liquid ventilation (PLV) and lung injury: Is PLV able to modify pulmonary vascular resistance?

Cited by 16 publications

References 15 publications

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Liquid-assisted ventilation: An alternative respiratory modality

Ventilação líquida: revisão da literatura

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