"Outbreak" is a term referring to a virus or a parasite that is transmitted very aggressively and therefore could potentially cause fatalities, as the recent Ebola and Zika epidemics did. Nevertheless, looking back through history, quite a few outbreaks have been reported, which turned out so deadly that essentially changed, molded and literally reshaped the society as it is today. In the present chapter, differences and similarities between the two most recent outbreaks have been studied, in order to pinpoint and design a trace model that will allow us to draw some conclusions for the connection of those two epidemics. Due to the high dimensionality of the problem, modern and state of the art geo-epidemiological methods have been used in an effort to provide the means necessary to establish the abovementioned model. It is only through geo-epidemiological analysis that it is possible to analyze concurrently a multitude of variables, such as genetic, environmental, behavioral, socioeconomic and a series of related infection risk factors.