Patterns of brain injury in neonates exposed to perinatal sentinel events

Okereafor, Akudo; Allsop, JM; Counsell, Serena; Fitzpatrick, Julie; Azzopardi, Denis; Rutherford, Mary; Cowan, Frances

doi:10.1016/j.earlhumdev.2006.09.021

Cited by 34 publications

(51 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, PPWMI patterns concerned 30% of the early MRI findings (all seen on DWI) and 30% of the late MRI findings analyzed in this study. These lesions were classified as normal in a previous study because they were considered difficult to distinguish from a normal appearance [23]. Indeed, this pattern was the subject of most of the disagreement between the radiologists in our study, reflecting the difficulty in detecting these subtle abnormalities.…”

Section: Signal Changes In the Posterior Limb Of Internal Capsule (Plic)mentioning

confidence: 72%

“…The findings of each MRI were clustered in patterns, described in Table 2 as normal, punctate periventricular white matter injuries, watershed, central, and diffuse patterns, based on previous studies [4,[21][22][23]. We clearly separated punctate periventricular white matter injury patterns because they have been associated with a good outcome, although this was not generally done in previous studies [4,22,24].…”

Section: Pattern Classificationmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of early and late MRI in neonatal hypoxic–ischemic encephalopathy using three assessment methods

Charon¹,

Proisy²,

Ferré³

et al. 2015

Pediatr Radiol

View full text Add to dashboard Cite

show abstract

Section: Signal Changes In the Posterior Limb Of Internal Capsule (Plic)mentioning

confidence: 72%

Section: Pattern Classificationmentioning

confidence: 99%

Comparison of early and late MRI in neonatal hypoxic–ischemic encephalopathy using three assessment methods

Charon¹,

Proisy²,

Ferré³

et al. 2015

Pediatr Radiol

View full text Add to dashboard Cite

show abstract

“…Similarly, neurotransmitters and neuromodulatory substances affect development in different ways at different stages in brain development; gammaaminobutyric acid, an inhibitory neurotransmitter, has an excitatory role until the last trimester and glutamate receptors are over-expressed in regions of the developing brain susceptible to injury. Consequently, mechanisms and effects of neurological insults differ between preterm and term infants (Back 2006;Dyet et al 2006;Ferriero 2004;McQuillen and Ferriero 2004;Okereafor et al 2008). For example, while severe hypoxic ischemia preferentially damages deep gray matter in preterm and term neonates, perirolandic involvement is more frequent in term neonates.…”

Section: In-utero Effectsmentioning

confidence: 99%

Extremely Preterm Birth Outcome: A Review of Four Decades of Cognitive Research

Baron

Rey‐Casserly

2010

Neuropsychol Rev

View full text Add to dashboard Cite

Premature birth incidence and survival rates are increasing steadily due to advances in obstetric and neonatal intensive care. Those born at the limits of viability are highly at-risk of adverse neurocognitive function over their lifespan, leading to current controversy regarding aggressive resuscitation efforts for these extremely preterm children. However, data from earlier generation cohorts who were born in substantially different eras of neonatal intensive care cannot be relied on to predict outcome of today's newborn. Our review by the crucial variable of birth cohort year shows a changing developmental trajectory in which today's extremely preterm survivor is likely to have fewer severe medical complications, better neurological outcomes, and fewer adverse cognitive late effects. Such data further underscore the importance of concurrently considering medical, familial, socioenvironmental, and neurobiological factors in combination with individual neonatal intensive care center protocols when studying outcomes of the preterm child. This complex, interrelated range of factors directly affects the immature, rapidly developing premature brain. However, ongoing surveillance to detect subsequent delay or impairment and to apply interventional strategies early in the developmental course holds promise for further enhancement of functional outcome.

show abstract

“…1,2 Despite the clinical importance of intrapartum hypoxia, the antenatal identification of the fetus at risk of cerebral palsy and other hypoxiarelated outcomes remains challenging.…”

mentioning

confidence: 99%