PCPA Increases Aggression in Male Firemouth Cichlids

Adams, Carolyn; Liley, N. R.; Gorzalka, Boris B.

doi:10.1159/000139446

Cited by 61 publications

(38 citation statements)

References 5 publications

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“…The monoamine 5-HT suppresses aggressive behavior (Adams et al, 1996), whereas DA stimulates it (Munro, 1986;Tiersch and Griffith, 1988). In addition, exposure to tryptophan, a precursor of 5-HT, stimulates serotonergic neurons and increases locomotor activity in medaka (Koutoku et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…In fish, serotonin (5-hydroxytryptamine) suppresses aggressive behavior (Adams et al, 1996), whereas dopamine (DA) stimulates such behavior (Munro, 1986;Tiersch and Griffith, 1988). In addition, TBT alters metabolism of DA in the midbrain of mice (Tsunoda et al, 2004) and reduces the concentrations of DA norepinephrine (NE), and serotonin in the whole brain of rats (Elsabbagh et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Nakayama¹,

Oshima²,

Tachibana³

et al. 2007

Environmental Toxicology

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ABSTRACT:We measured the concentrations of monoamines in the brain of Japanese medaka, Oryzias latipes, exposed to tributyltin (TBT). Fish were exposed to 0, 1, 5, 25, or 125 g g À1 of TBT via the diet for 21 days. After the administration period, six males and six females in each treatment group were dissected and their brains were collected. The following monoamines were analyzed: dopamine (DA), norepinephrine (NE), epinephrine (E), and 5-hydroxytryptamine (5-HT). The metabolites of DA, 3,4-dihydroxyphenylacetic acid and homovanilic acid, and the metabolite of 5-HT, 5-hydroxyindolacetic acid were also analyzed. The concentration of DA in the brain of male medaka and the concentrations of 5-HT and NE in the female brains were significantly decreased by exposure to 125 g TBT g À1. The concentrations of 5-HT and NE in males and of DA in females were slightly decreased by 125 g g À1 of TBT, although the differences were not statistically significant. The present study demonstrates that TBT alters monoamine concentrations in the brain of medaka. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 53-57, 2007.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Nakayama¹,

Oshima²,

Tachibana³

et al. 2007

Environmental Toxicology

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“…Во-первых, серотонин (5-гидрокситриптамин, 5-НТ) -эволюционно очень древний медиатор. Многочисленные данные свидетельствуют о его участии в регуляции агрес-сивного поведения не только млекопитающих (Попова и др., 1978; Valzelli et al, 1981;Molina et al, 1987;Miczek et al, 1989;Popova, 2006), но и животных других клас-сов -птиц (Sperry et al, 2003), рыб (Adams et al, 1996), ракообразных (Huber, 2005). Во-вторых, клинические данные показывают ассоциацию импульсивной агрес-сивности человека и суицида, который рассматривают как проявление агрессии, направленной на самого себя (Pedder, 1992), с недостаточной функциональной активно-стью серотониновой системы мозга (Linnoila et al, 1983;Linnoila, Virkkunen, 1992;Arango et al, 2003).…”

Section: серотонин и доместикацияunclassified

The domestication and the brain: forty years after

Попова¹

2017

Vestn. VOGiS

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The domestication of animals was crucial for the civilization evolutionary experiment. The main characteristic of domesticated animal is tame behavior towards man. D.K. Belyaev suggested that the domestication was carried out by man of the Stone Age as unintended selection of nonaggressive animals. This hypothesis was confirmed at the Institute of Cytology and Genetics, Novosibirsk, by unique long-lasting selection of silver foxes, Norway rats and American minks for nonaggressive behavior towards man. The review concentrates on the role of the brain neurotransmitters in the mechanism of animal domestication. Specifically, it describes the effect of selective breeding for nonaggressive behavior on the brain neurotransmitter serotonin (5-HT) system. Our data showed that produced by domestication the conversion of wild, aggressive animal to non-aggressive towards man is associated with changes in the expression of key molecular members determining the brain 5-HT system functioning. Significant difference between aggressive and nonaggressive animals in the 5-HT metabolism, in the expression of principle metabolic enzymes and 5-HT receptors was shown in different species of mammals (sil ver foxes, Norway rats and American minks). Higher concentration of 5-HT and its metabolite, 5-hydroxyindoleacetic acid, increased activity of the principle enzyme in 5-HT synthesis (tryptophan hydroxylase-2) and decreased activity of the principle enzyme in 5-HT degradation (monoamine oxidase A) was shown in the midbrain of domesticated silver foxes and rats. The expression of the 5-HTA receptor gene, the density and functional activity of 5-HTA receptors in nonaggressive rats were increased. The review provides converging lines of evidence for our hypothesis that the changes in the brain 5-HT contributes to a mechanism underlying correlative patterns of domestication, i.e. changes in the pivotal for stress response and for the reproduction pituitary-adrenal and pituitary-gonadal systems.Key words: domestication; aggressiveness; neurotransmitters; serotonin; correlative traits; stress-response; pituitary-gonadal system. Доместикация диких животных -краеугольный камень цивилиза-ции. Идея Д.К. Беляева об основе доместикации как бессознатель-ном отборе человеком каменного века неагрессивных животных была подтверждена многолетними уникальными работами Инсти-тута цитологии и генетики по доместикации серебристо-черных лисиц, крыс-пасюков и американских норок. Обзор посвящен роли медиаторов мозга в механизмах доместикации. Полученные в на-ших исследованиях данные свидетельствуют об участии серото-ниновой системы мозга в перестройке поведения при селекции животных на низкую агрессивность. Установлено, что доместика-ция, превращающая агрессивное дикое животное в неагрессив-ное и дружелюбное, сопровождается у животных разных видов (серебристо-черных лисиц, крыс-пасюков и норок) изменением основных молекулярных элементов, определяющих функциональ-ную активность серотониновой системы. Агрессивные и неагрес-сивные животные различаются по уровню с...

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“…Since 5HT was reported to suppress aggressive behavior in teleost fish (Adams et al ., 1996), it was suggested that TRP stimulated brain 5HTnergic systems and then altered aggressive behavior. This result demonstrated that exogenous TRP can modify the brain 5HTnergic activity.…”

Section: Introductionmentioning

confidence: 99%