Pectin in biomedical and drug delivery applications: A review

Li, De qiang; Li, Jun; Dong, Hui; Li, Xin; Zhang, Jia qi; Ramaswamy, Shri; Xu, Feng

doi:10.1016/j.ijbiomac.2021.06.088

Cited by 237 publications

(102 citation statements)

References 156 publications

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“…Since the discovery of pectin in 1825, numerous advances have been made regarding the source of raw materials used for extraction, the extraction techniques, structural modifications, and applications of this polysaccharide [26]. Researchers interested in this area have been using the extraction optimization process to facilitate subsequent industrial applications [8,52,55,[140][141][142].…”

Section: Prospects Future Trends and Challengesmentioning

confidence: 99%

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

et al. 2021

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Pectin is a biocompatible polysaccharide with intrinsic biological activity, which may exhibit different structures depending on its source or extraction method. The extraction of pectin from various industrial by-products presents itself as a green option for the valorization of agro-industrial residues by producing a high commercial value product. Pectin is susceptible to physical, chemical, and/or enzymatic changes. The numerous functional groups present in its structure can stimulate different functionalities, and certain modifications can enable pectin for countless applications in food, agriculture, drugs, and biomedicine. It is currently a trend to use pectin to produce edible coating to protect foodstuff, antimicrobial bio-based films, nanoparticles, healing agents, and cancer treatment. Advances in methodology, use of different sources of extraction, and knowledge about structural modification have significantly expanded the properties, yields, and applications of this polysaccharide. Recently, structurally modified pectin has shown better functional properties and bioactivities than the native one. In addition, pectin can be used in conjunction with a wide variety of biopolymers with differentiated properties and specific functionalities. In this context, this review presents the structural characteristics and properties of pectin and information on the modification of this polysaccharide, its respective applications, perspectives, and future challenges.

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Section: Prospects Future Trends and Challengesmentioning

confidence: 99%

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

et al. 2021

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“…It is biocompatible and biodegradable, and it is soluble in cytocompatible and non-toxic solvents (such as water). Pectin is a versatile biomaterial as its physical properties can be facilely tuned due to the presence of several functional groups (e.g., carboxylic groups) that can serve as binding sites for other functional groups, biomolecules and drugs [21][22][23]. It is a low-cost biomaterial due to its ubiquity in nature, and this can strongly reduce the costs associated with the development of engineered tissues.…”

Section: Properties Of Pectin As a Biomaterials For Te Applicationsmentioning

confidence: 99%

“…The application of more ecologically viable biomaterials in TE may, in fact, strongly contribute to reduce the polluting impact of producing and using un-recyclable synthetic biopolymers. Among the renewable and natural biopolymers, pectin is gaining particular attention in TE for its advantageous properties including biocompatibility, biodegradability and non-toxicity [21,22]. In addition, the versatility in processing pectin-based formulations allows to produce scaffolds with diverse properties and for different applications (Section 2).…”

Section: Introductionmentioning

confidence: 99%

Pectin-Based Scaffolds for Tissue Engineering Applications

Lapomarda¹,

Acutis²,

Maria³

et al. 2022

Pectins - The New-Old Polysaccharides

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Tissue engineering (TE) is an interdisciplinary field that was introduced from the necessity of finding alternative approaches to transplantation for the treatment of damaged and diseased organs or tissues. Unlike the conventional procedures, TE aims at inducing the regeneration of injured tissues through the implantation of customized and functional engineered tissues, built on the so-called ‘scaffolds’. These provide structural support to cells and regulate the process of new tissue formation. The properties of the scaffold are essentials, and they can be controlled by varying the biomaterial formulation and the fabrication technology used to its production. Pectin is emerging as an alternative biomaterial to non-degradable and high-cost petroleum-based biopolymers commonly used in this field. It shows several promising properties including biocompatibility, biodegradability, non-toxicity and gelling capability. Pectin-based formulations can be processed through different fabrication approaches into bidimensional and three-dimensional scaffolds. This chapter aims at highlighting the potentiality in using pectin as biomaterial in the field of tissue engineering. The most representative applications of pectin in preparing scaffolds for wound healing and tissue regeneration are discussed.

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“…Do mang đặc tính không gây độc nên pectin được sử dụng rộng rãi làm hệ mang thuốc. Đặc biệt, sự kết hợp giữa pectin methoxyl hóa thấp (độ ester hóa DE < 50%) và cation hóa trị 2 (ion canxi) làm giảm độ hòa tan và tạo ra các liên kết không hóa trị (non-covalent interaction) của các chuỗi cacbohydrat, dẫn tới hình thành phức hợp pectinat canxi [7], [8]. Đây chính là nguyên lý của phương pháp tạo gel ion, nhằm mục đích tăng cường sinh khả dụng và kiểm soát quá trình giải phóng các chất có hoạt tính sinh học [9].…”

Section: đặT Vấn đềunclassified

Nghiên Cứu Tạo Nang Micro Curcumin Bằng Phương Pháp Tạo Gel Ion

Hùng¹,

Ngà²

2021

TNUJST

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Curcumin có nhiều hoạt tính sinh học mạnh như kháng oxy hóa, kháng khuẩn, kháng viêm, kháng khối u... Tuy nhiên, sinh khả dụng và độ hòa tan của curcumin thấp, tốc độ giải phóng nhanh, hấp thu kém do đặc tính ít tan trong nước. Để khắc phục các hạn chế của curcumin, phương pháp tạo gel ion đã được sử dụng trong nghiên cứu này, với sự kết hợp đồng thời của pectin, chất hoạt động bề mặt Solutol® HS 15 và ion canxi hóa trị 2, nhằm tạo ra viên nang curcumin có kích thước micro. Kết quả cho thấy, hiệu suất bào chế, hình thái và kích thước của nang micro curcumin bị thay đổi khi thay đổi lượng Solutol® HS 15. Hoạt tính kháng oxy hóa của nang micro curcumin có bổ sung Solutol® HS 15 với nồng độ từ 25% (w/v) thay đổi không đáng kể so với bột curcumin nguyên liệu. Từ đó, công thức thích hợp để bào chế nang micro curcumin đã được tối ưu và lựa chọn.

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Pectin in biomedical and drug delivery applications: A review

Cited by 237 publications

References 156 publications

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

Pectin-Based Scaffolds for Tissue Engineering Applications

Nghiên Cứu Tạo Nang Micro Curcumin Bằng Phương Pháp Tạo Gel Ion

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