Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract

Vityazev, Fedor V.; Fedyuneva, Maiia I.; Golovchenko, Victoria V.; Patova, Olga A.; Ipatova, E. U.; Durnev, Eugene A.; Martinson, Ekaterina A.; Litvinets, Sergey G.

doi:10.1016/j.carbpol.2016.09.048

Cited by 60 publications

(22 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidized pectin (P100) signified a few distinguishing peaks. The bands appeared at 3431, 2938, 1734, and 1622 cm −1 corresponded to respective OH vibration, COOCH 3 stretching vibration, either COOH stretching vibration or HCO vibration, and RCOR' stretching vibration . In oxidized polysaccharides, aldehyde related bands usually appears in the range of 1700–1750 cm ‐1 .…”

Section: Resultsmentioning

confidence: 96%

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

Hydrogels possessing high mechanical strength and well-controlled properties are of utmost interest in bone tissue engineering. In the current study, a strong self-crosslinked hydrogel with variable properties has been developed from a combinatory composition of functionalized pectin and silk fibroin. Pectin chains underwent partial oxidation to be decorated with aldehyde functionalities. Later on, functionalized polysaccharide and protein were blended with different ratios, and corresponding variations in crystalline structure as well as in morphological, mechanical, and rheological properties have been monitored. Some theories have been used to better perceive the relation between blending ratio and hydrogel properties. Avrami equation based on time sweep rheological analysis elucidated that in sample with equivalent ratio of oxidized pectin and fibroin, the crystallization was highly delayed due to dominance of Schiff's base reaction. The Herschel-Bulkley model based on flow curve rheology test corroborated that aforesaid composition revealed the most noticeable shear thinning behavior and accordingly the strongest crosslinked network. Finally, rubber elastic theory based on dynamic mechanical analysis implied that said formulation possessed the highest crosslinking density due to higher availability of aldehyde to amine functionalities. Moreover, cell culture studies proved that P50 F50 sample prevailed over other compositions with respect to cell viability and function.

show abstract

Section: Resultsmentioning

confidence: 96%

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The primary targets of this work were to synthesize novel functional organicinorganic hybrid materials and to check their ability to remove metal ions from aqueous solution. The structural order, morphology, and texture of the prepared hybrid gels were studied by FTIR, 13 C CP MAS NMR spectroscopy, SEM, and nitrogen adsorption-desorption analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The experimental parameters for the 13 C CP MAS NMR were 9 KHz SPIN rate, 5 s pulse delay. NMR spectroscopy was carried out on an MSL 500 Bruker Spectrometer.…”

Section: Characterizationmentioning

confidence: 99%

“…In class I, organic and inorganic components are strongly attached by covalent or dative covalent bonds, while in the second, these two components are weakly bonded through hydrogen or Van der Waals bonds. Indeed, these materials have generated considerable interest for their potential application in multiple fields such as: adsorption [11], drug delivery systems [12,13], biosensors [14], nanotechnology, and nanomedicine applications [15,16] and catalysis [17]. Organic-inorganic hybrid materials displayed high efficiency and outstanding selectivity towards target pollutant than the other silica gels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bi-Functionalized Hybrid Materials as Novel Adsorbents for Heavy Metal Removal from Aqueous Solution: Batch and Fixed-Bed Techniques

Hannachi¹,

Hafidh²,

Ayed³

2020

Water Chemistry

View full text Add to dashboard Cite

In this study, two new mesoporous hybrid gels were synthesized. The structural order, morphology, and textural properties of the prepared hybrid materials have been studied by 13 C CP MAS NMR, SEM, FTIR, and nitrogen adsorption-desorption analysis. The application for the heavy metal uptake from aqueous solution using the as-synthesized hybrid materials as an adsorbent is explored. Operating parameters influencing the adsorption procedure, for instance, solution pH, contact time, and temperature are contemplated. In order to gain an insight into the adsorption mechanism and reveal the rate-controlling steps, three models pseudo-first-order, pseudo-second-order, and intra-particle diffusion have been studied to fit. Langmuir, Freundlich, and Dubinin-Radushkevich (D-R) models are assigned to portray the adsorption isotherms. Besides, the feasibility of the synthesized adsorbents for a continuous process in fixed-bed column was investigated. Prior tests produced on electroplating effluents reveal that the as-prepared xerogel could be strongly used for the heavy metal uptake from real wastewater.

show abstract

“…Ulcerative colitis is a severe disease of the digestive system with annual incidence rate ranging from 25 to 240 per 100 thousand persons, and the number of ulcerative colitis had increased greatly which led to the rise of medication requirements . 5‐Aminosalicylic acid (5‐ASA) have received a lot of attention as one of the important drugs for the treatment of ulcerative colitis, but due to its instability when exposed to the stomach conditions its rapid metabolization and inactivation in the intestinal mucosa greatly limits its full use . Therefore, the choice of an appropriate drug release carrier for high efficiency of 5‐ASA is necessary.…”

Section: Introductionmentioning

confidence: 99%

The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel

Yuan

Yan

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen-bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized-distilled water and pH 7.2 PBS. The release of 5-aminosalicylic acid (5-ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5-ASA release.

show abstract

Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract

Cited by 60 publications

References 49 publications

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Bi-Functionalized Hybrid Materials as Novel Adsorbents for Heavy Metal Removal from Aqueous Solution: Batch and Fixed-Bed Techniques

The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel

Contact Info

Product

Resources

About