Pediatric cerebellar giant cavernous malformation: case report and review of literature

Villaseñor-Ledezma, Javier; Budke, Marcelo; Álvarez-Salgado, J.A.; Cañizares, María-Angeles; Villarejo, F.

doi:10.1007/s00381-017-3550-7

Cited by 11 publications

(15 citation statements)

References 16 publications

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“…Although bleeding from a cavernoma is expected in the third and fourth decades of life, bleeding in GCs is more likely to occur in small children 5,10,11 , as well as at the age similar to our patient 15 . Localization was typical, as the majority of GCs found in the literature were located in the frontoparietal region 3,6 .…”

Section: Discussionsupporting

confidence: 46%

“…Cavernomas (cavernous angiomas, hemangiomas) are benign, clearly defined, angiographically occult vascular malformations of the central nervous system, which are composed of vascular channels lined by one-layer endothelium separated by matrix made of collagenous tissue and smooth muscles [1][2][3] . Their prevalence ranges from 0.5% to 1% in the general population, and they account for 5%-15% of all intracranial vascular malformations [3][4][5][6][7][8][9][10] . They can be from a few millimeters to a few centimeters in size, usually smaller than 3 cm.…”

Section: Introductionmentioning

confidence: 99%

“…They can be from a few millimeters to a few centimeters in size, usually smaller than 3 cm. The average diameter is about 1.5 cm 1,3,6,[10][11][12][13] . Multiple cavernomas can occur, and they are usually familial 14 .…”

Section: Introductionmentioning

confidence: 99%

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Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report

Grujić

Jovanović

Tasić

et al. 2020

ACC

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Giant cavernomas (GC) are rare lesions, with less than 50 cases reported so far. Clinical presentation usually involves epileptic seizures and less typically focal neurological deficit, due to repeated hemorrhages and GC mass effect and consequentially increased intracranial pressure. Although individual cases have been reported, due to the rarity and variable imaging appearance, GCs are usually not considered in the differential diagnosis of large hemorrhagic lesions, especially when significant mass effect is present. A 17-year-old boy presented due to severe headache, right-sided weakness, and slurred speech. Symptoms started three days before with occasional headaches, which intensified gradually. Emergency computed tomography revealed a left frontal massive heterogeneous lesion. Soon after, right-sided hemiparesis and speech impairment progressed, and the patient became drowsy with the slightly dilated left pupil. Emergency surgery was performed, and the lobed grayish lesion was entirely removed. Based on the macroscopic appearance, the surgeon assumed it was a metastasis of melanoma. Histopathologic analysis result was cavernoma. GC should be considered as an option in hemorrhagic lesions, especially in the young age population. Emergency surgery for mass lesions is not uncommon in neurosurgery; however, bleeding cavernomas are usually planned for elective surgery due to the specific approach and complications.

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Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

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Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report

Grujić

Jovanović

Tasić

et al. 2020

ACC

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“…9 GCMs in children, however, have an increased hemorrhage risk and are more aggressive compared with those in adults, implying distinct, age-related biological behaviors. 19 To the best of our knowledge, GCMs have never before been detected incidentally or reported as asymptomatic. 4 Sansone et al reported a 72-year-old woman with metastatic breast carcinoma who had a dumbbell-shaped cavernous lesion in the pituitary region that was detected incidentally on post-mortem examination.…”

Section: Discussionmentioning

confidence: 92%

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Zhen

Wang

2020

J Int Med Res

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Cavernous malformations are benign vascular malformations. Giant cavernous malformations are very rare. All reported cases have been symptomatic because of the large size and compression of the surrounding brain tissue. We report two asymptomatic cases of giant cavernous malformation that were both misdiagnosed as neoplasms because of their atypical presentations. The first case was a 54-year-old man whose computed tomography and magnetic resonance imaging scans revealed an inhomogeneous lesion of 6 cm diameter and mild enhancement in the left frontal lobe. A left lateral supraorbital and transcortical approach was applied and the lesion was completely removed. The second case was a 36-year-old man with an irregular large mass in the parasellar region. Craniopharyngioma was suspected and gross total resection was performed. Post-surgical pathological analyses confirmed the diagnoses as cavernous malformations. Both patients recovered uneventfully. The rare asymptomatic giant cavernous malformations reported here in adults had benign behavior for this specific disease entity. The different clinical characteristics of ordinary cavernous malformation and adult and pediatric giant cavernous malformation imply complex and distinct genetic backgrounds. Concerns should be raised when considering giant cavernous malformation as a differential diagnosis for atypical large lesions. Surgical resection is recommended as the primary treatment option.

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“…The surgical resection is currently seen as the best therapy available for symptomatic cases 14 . In large CM, due to the lesion size, the patient will invariably become symptomatic, making surgical treatment necessary regardless of the presence of symptoms [15][16][17] .…”

Section: Introduction Case Presentationmentioning

confidence: 99%

Large cavernous malformations in infant

Britz¹,

Sonda²,

Calloni³

et al. 2021

jbnc

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Cavernous malformations are rare vascular malformations in the central nervous system. We present the case of a 2-month-old female patient who presented tonic-clonic seizures, with no previous history of seizures. Magnetic resonance imaging showed a 5.6 cm tumor in the left parieto-occipital region. The radiological aspect of the tumor initially suggested an anaplastic meningioma. After surgical treatment and anatomopathological analysis, it was found to be a cavernous malformation. Cavernous malformations, or cavernomas, are rare lesions and even more rare is the occurrence of large cavernomas. In the pediatric population, although still quite rare, they usually are presented as larger cavernomas. Surgical resection is considered the most effective treatment.

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Pediatric cerebellar giant cavernous malformation: case report and review of literature

Cited by 11 publications

References 16 publications

Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report

Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Large cavernous malformations in infant

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