PEGylated rosin derivatives: Novel microencapsulating materials for sustained drug delivery

Morkhade, Dinesh M.; Nande, Vishwanath S.; Barabde, Umesh V; Patil, Arun T.; Joshi, S. B.

doi:10.1208/pt0802047

Cited by 19 publications

(16 citation statements)

References 18 publications

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“…From this result it can suggest than melting point of derivative was affected from rosin content and melting point of PEG. This result shows consistent with previous study [4], [14], [19]. C-NMR spectra of rosin-PEG 1500 derivatives.…”

Section: International Journal Of Chemical Engineering Andsupporting

confidence: 94%

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Kanlaya¹,

Sumrit²,

Amorn³

2016

IJCEA

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Abstract-This research aims to synthesize and characterize of rosin-polyethylene glycol derivatives from natural rosin and polyethylene glycol 1500 (PEG1500). In this research, reaction conditions for the synthesis of rosin-PEG derivatives such as catalyst type, catalyst concentration, reaction temperature and etc. were optimized. Chemical and physical properties of water soluble rosin (WSR) were characterized using FT-IR, 13 C-NMR, DSC, and GPC. It was found that water soluble rosin-PEG derivatives were successful synthesized from natural china rosin and PEG using 2% ZnO as catalyst, 2:1 molar ratio of rosin: PEG at 250 O C for 9 hours. The obtained rosin-PEG1500 derivative were completely soluble in water and rosin-PEG1500 derivative showed melting point at 40.6Index Terms-Water soluble rosin, polyethylene glycol 1500, esterification, zinc oxide.

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Section: International Journal Of Chemical Engineering Andsupporting

confidence: 94%

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Kanlaya¹,

Sumrit²,

Amorn³

2016

IJCEA

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“…The two reactive functionalities are capable of undergoing various chemical reactions with appropriate reagents. 13 Accordingly, the present work aims to prepare nonionic surfactants based on rosin gum to apply as sludge dispersants. In this respect, nonionic surfactants based on rosin ester of rosin acids with PEG having different molecular weights 400, 600, 1000, and 2000 g/mol were prepared.…”

Section: Resultsmentioning

confidence: 99%

Use of rosin‐based nonionic surfactants as petroleum crude oil sludge dispersants

Atta

El-Saeed

2011

J of Applied Polymer Sci

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The present work provides better knowledge for composition analyses of the sludge and evaluates the best effective and economical treatment of petroleum sludge. In this respect, nonionic polymeric surfactants based on rosin were prepared by esterification of rosin with different molecular weights of polyethylene glycol (PEG 400, 600, 1000(PEG 400, 600, , 2000 to produce rosin ester surfactants. The esterified rosin was reacted with maleic anhydride followed by reaction with diaminobutane or triethylene tetramine to produce rosin-imide. The products were etherified with PEG 600 and PEG 2000 to produce rosin-imide ERID-1, ERID-2, ERIT-1 and ERIT-2, which were characterized by FT-IR and 1 H-NMR analyses. The surfactants were tested as sludge dispersants from viscosity measurements of sludge crude oil mixtures at different times.

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“…Therefore, rosin has been extensively used as a raw material for the preparations of various derivatives. Rosin and its ester derivatives are widely used in coating and microencapsulating agents [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Adsorption Behavior of Trimethylolpropane‐Dehydroabietic Acid Ester at the Air–water Interface

Zhou

Yang

Liang

et al. 2016

J Surfact & Detergents

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A novel amphipathic trimethylolpropane‐dehydroabietic acid ester was successfully prepared with acyl chloride method. Various analytical techniques such as liquid chromatography–mass spectrometry, Fourier transform infrared spectrometry, proton and carbon nuclear magnetic resonance spectroscopy were employed to evaluate the chemical structure of the ester. The surface properties of the ester were investigated by surface tension and resonance light‐scattering techniques. The surfactant molecules are adsorbed at the water–air interface in different adsorption states, i.e., state 1 and 2. The dynamic adsorption behavior was studied by combining experimental results and a reorientation model. The molar fraction of solvent decreased, while the molar fraction of surfactant molecules increased with increasing ester concentration at the surface layer. The adsorption value of state 1 presented a unimodal shape and the adsorption value of state 2 presented an s‐shape with the increase in surface pressure. The free energy of adsorption is −36.06 kJ mol−1, more negative than the free energy of micellization (−29.69 kJ mol−1), it is actually easier for surfactant molecules to adsorb on the air–water interface.

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PEGylated rosin derivatives: Novel microencapsulating materials for sustained drug delivery

Cited by 19 publications

References 18 publications

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Use of rosin‐based nonionic surfactants as petroleum crude oil sludge dispersants

Adsorption Behavior of Trimethylolpropane‐Dehydroabietic Acid Ester at the Air–water Interface

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