Pelletization Technology: Methods and Applications-A Review

Ahir, Amita A.; Mali, Sachin S.; Hajare, Ashok A.; Bhagwat, Durgacharan A.; Patrekar, Prasad V.

doi:10.5958/0974-360x.2015.00023.2

Cited by 15 publications

(7 citation statements)

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“…HME is a green synthesis technique as it avoids the use of organic solvents showing maximum scalability using the process. Researchers have been working on pellet formulations of different drugs using HME as shown in Table 1 (Ahir et al, 2015;Politis and Rekkas, 2011).…”

Section: Hme Techniquementioning

confidence: 99%

Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Roychowdhury¹,

Kara²,

Rathnanand³

2020

J Appl Pharm Sci

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The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity, and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system.

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Section: Hme Techniquementioning

confidence: 99%

Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Roychowdhury¹,

Kara²,

Rathnanand³

2020

J Appl Pharm Sci

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“…Firstly, as the pelletization process involves high temperature (>80 °C) and pressure (10–20 N), the diet shows increased digestibility by modifying polysaccharides and proteins, affecting the secondary structure of proteins and changing the α‐helix‐to‐β‐sheet ratio, modifying amino acid proportions (Seguchi et al, 2004; Yu, 2005, 2006; Sibanda & Ruhnke, 2017). Secondly, pelletization improves the nutrient distribution in the diet (Ahir et al, 2015). Diets enriched with amino acids (e.g., l ‐arginine) promote larval growth and metamorphosis in a dose‐dependent manner in Drosophila melanogaster Meigen (Bayliak et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a pelleted diet for larval mass‐rearing of Anastrepha ludens and Anastrepha obliqua

Aceituno‐Medina¹,

Rivera-Ciprian²,

Hernández³

2020

Entomologia Exp Applicata

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Most artificial diets used for mass‐rearing of fruit fly larvae involve the purchase and independent weighing of each ingredient of the formulation, followed by mixing and diet preparation process. A ready‐to‐use formulation would avoid this time‐consuming task and simplify the preparation procedure, leading to a more standardized diet. In this work, we compared life‐history traits and survival and developmental parameters of Anastrepha ludens Loew and Anastrepha obliqua (Macquart) (Diptera: Tephritidae) reared on two formulations of an artificial diet. Two experiments were performed; first, a conventional non‐pelleted diet was compared to a newly developed pelleted diet, which was mixed with water before being given to the larvae. The second experiment consisted of a comparison between the pelleted diet which was stirred in a mixer with water and dissolved preservatives and a pelleted diet which was only soaked in water with dissolved preservatives. We found that the pelleted diet allowed the mass‐rearing of A. ludens and A. obliqua. Moreover, feeding larvae with pelleted diet led to increased weight of the larva by 7.4 and 11.8%, and of the pupa by 9.5 and 16.7% for A. ludens and A. obliqua, respectively, compared to conventional diet. For process evaluation, the number of activities, handling time, reception, storage, and larval diet preparation were recorded. The pelleted diet only needed soaking in water containing preservatives, thereby simplifying the mass‐rearing process and saving time, space, and labour. Pelletizing is a versatile technology that can be adjusted for better physicochemical quality and reduced microbiological risk. This diet should be of particular interest for the mass‐rearing process in ‘sterile insect technique’ applications.

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“…The manufacturing process of lightweight aggregates (LWAs) has the same steps as the structural ceramics, with the substantial difference in the shaping processes, which occur in a pelletizer. Pelletization is a method of agglomeration that permits the particle-size enlargement, in which ceramic powders are processed into pellets or granules of dimensions between 0.5 and 2.0 mm [ 15 ]. Pelletization is not a typical forming technique of traditional ceramics; it is used in a multitude of industries (pharmaceutical, food, fertilizer, etc.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Three Manufacturing Techniques for Sustainable Porous Clay Ceramics

et al. 2020

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This study proposes different manufacturing techniques (manual pelletization, powder pressing, and “shell scaffold”) to obtain lightweight clay ceramics containing recovery raw materials. The sintering in an electrical furnace (1000 °C, 1 h processing time) was conducted by traditional firing from room temperature, for pressed and shell-scaffold samples, while the flash heating (i.e., samples directly put at 1000 °C) was used only for the pellets. The porous materials (porosity 40–80%), functionalized with nutrients (K and P) in amounts to confer the fertilizer capability, gave suitable results in terms of pH (6.7–8.15) and electrical conductivity (0.29–1.33 mS/cm). Thus, such materials can be considered as feasible lightweight clay ceramics, with a positive effect on the soil. These findings permit us to hypothesize a potential use in green roofs or in agronomic applications.

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Pelletization Technology: Methods and Applications-A Review

Cited by 15 publications

References 0 publications

Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Evaluation of a pelleted diet for larval mass‐rearing of Anastrepha ludens and Anastrepha obliqua

Comparison of Three Manufacturing Techniques for Sustainable Porous Clay Ceramics

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