Penetration of Topically Applied Dexamethasone Alcohol Into Human Aqueous Humor

Watson, David; Noble, Mark J.; Dutton, Gordon N.; Midgley, John M.; Healey, T.

doi:10.1001/archopht.1988.01060130748037

Cited by 55 publications

(20 citation statements)

References 11 publications

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“…Treatment drugs were administered in dif ferent approaches, according to their effec tiveness proved previously by other authors [23][24][25][26], According to inflammatory-index results at 24 h and to the significant differences found, groups 3-5 showed the best improve ments. They did not present significant differ ences between each other (p < 0.05, Kruskal Wallis).…”

Section: Discussionmentioning

confidence: 43%

Combined Non-Steroidal Therapy in Experimental Corneal Injury

Laria¹,

Alió²,

Ruiz-Moreno³

1997

Ophthalmic Res

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Purpose: The effects of anti-inflammatory non-steroidal therapy combined with free-radical scavengers were studied and compared to corticosteroid use in the treatment of experimental corneal injury. Method: Eighty New Zealand albino rabbits were used in this study. A corneal alkali burn was induced by applying 1-N NaOH filter paper on the central axis of the right cornea for 30 s. Animals were distributed into five treatment groups: group 1 (control group) was only given gentamicin; group 2 was treated with 0.5% dimethylthiourea (DMU); group 3 received 1 % dexamethasone; group 4 was given combined 0.5% DMU and 1% indomethacin; group 5 was treated with 0.5% DMU and 0.1% diclofenac sodium. One 50-μl drop of gentamicin was instilled every 12 h, whereas the other drugs were instilled every 6 h (50 μl). All groups received the same antibiotic treatment as the control group. The animals were killed on the 5th day. Inflammatory index, area and perimeter of the wounded corneal zone, and corneal transparency were evaluated. Results: No significant differences in the inflammatory index were found between the treatment groups and the control group after 72 h. Significant differences (p < 0.001) were observed at 24 h in groups 3–5 when compared with the control group. Planimetry showed significant differences in group 4 when compared with the other groups (p < 0.05). Corneal transparency study showed statistically significantly better values in groups 4 and 5, when compared with the other groups, including group 3 (p < 0.05). Conclusions: The use of 0.5% DMU combined with 1% indomethacin can be considered an alternative to corticosteroid treatment in our experimental chemical corneal injury.

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Section: Discussionmentioning

confidence: 43%

Combined Non-Steroidal Therapy in Experimental Corneal Injury

Laria¹,

Alió²,

Ruiz-Moreno³

1997

Ophthalmic Res

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“…4,5,6 They are the main drugs that have been used so far for controlling postoperative inflammation after intraocular surgery. Steroids act by inhibiting production of factors (prostaglandins, leukotrienes etc.…”

Section: Discussionsupporting

confidence: 42%

Comparative evaluation of the antiinflammatory effect of topical 0.1% dexamethasone sodium and topical 1% prednisolone acetate eye drops after small incision cataract surgery in Indian eyes

Misra¹,

Gaydhankar²,

Mehta³

2012

DJO

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“…Using HPLC for the analysis, the drug penetrating into the aqueous humour has been determined as dexamethasone after the treatment of the samples with alkaline phosphatase prior to the analysis (Bodker et al, 1993). So far the penetration of dexamethasone has been investigated with GCMS (Watson et al, 1988).…”

Section: Introductionmentioning

confidence: 44%

“…During recent years, a combination of gas chromatography with mass spectroscopy (GCMS) (Watson et al, 1988McGhee et al, 1990) as well as HPLC (High Performance Liquid Chromatography) (Kristinsson et al, 1996 ;Loftsson et al, 1994 ;Bodker et al, 1993) have been found to be a highly sensitive and specific techniques to study penetration of topically applied corticosteroids into the human aqueous humour. However, because of the variation in the lipophilic and hydrophilic properties of the different drug formulations and the drug metabolites, specific enzymatic, extraction and derivatization methods have to be applied to investigate the different steps in the drug metabolism with these methods.…”

Section: Introductionmentioning

confidence: 46%