Pengaruh pengobatan konservatif terhadap “mucociliar clearance” tuba Eustachius penderita OMSK benigna aktif

Hadiningsih, Chintriany; Sedjawidada, Raden; Kodrat, Linda; Kadir, Abdul

doi:10.32637/orli.v40i2.5

Cited by 2 publications

(2 citation statements)

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“…Conservative treatment given in their study included ear toilets, topical antiseptic (burrowi tampons), oral systemic antibiotics (cefadroxil) and oral corticosteroids. (20) Transformation in the mean mucociliary transport time became faster in the same group. This happened after giving therapy to both groups.…”

Section: Discussionmentioning

confidence: 94%

Erdosteine for mucociliary transport in benign chronic suppurative otitis media

Ridwan¹,

Haroen²,

Alia³

et al. 2022

GSC Adv. Res. Rev.

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Background: Current treatment for CSOM is still unsatisfactory, many factors contributed in this condition. Impaired mucociliary clearance of the Eustachian tube can be a predisposing factor for recurrent otitis media and slow healing of the middle ear mucosa, local circulation and improvement of middle ear pressure. During process of middle ear infection, mucus production commonly found, the middle ear and the Eustachian tube are disturbed. The erdosteine effects of increase epithelial mucociliary transport are well documented. Objectives: To investigate the effectiveness erdosteine in mucociliary transport of benign CSOM. Method: sixteen (16) patients with benign CSOM were experimental research, using pretest-posttest control group design method with random sampling. The two main comparisons were transport mucocilary time compared to a) erdostein and b) no erdostein. Result: The study analyzed the interval time of mucociliary transport between pretest and posttest was measured in studied patients. The transition time from pretest to posttest with erdosteine from 24:36:22 to 16:28:32 minutes (p=0,006) and without erdostein from 22:12:39 to 19:18:19 minutes (p=0,029). There is a difference in transportation time before and after administration of erdostein. However, there were no significant difference in mucociliary transport time from pretest to posttest between 2 groups (p=0.682). Conclusions: The results of our study indicate that erdosteine is correlated with increased mucociliary transport. Eventhough the interval time have no significance different between erdorsteine group and without erdorsteine group.

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Section: Discussionmentioning

confidence: 94%

Erdosteine for mucociliary transport in benign chronic suppurative otitis media

Ridwan¹,

Haroen²,

Alia³

et al. 2022

GSC Adv. Res. Rev.

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“…Menurut penelitian yang ditulis oleh Adoga et al, 6 OMSK sering dialami oleh anak dibawah 5 tahun sebesar 79,5% namun dapat juga dialami oleh penderita dewasa. Pada penelitian yang dilakukan oleh Hadiningsih dkk, 7 sampel terbanyak didapatkan pada usia 14 -25 tahun sebesar 48,4%.…”

Section: Diskusiunclassified

Pengaruh N–asetilsistein terhadap transpor mukosilia tuba Eustachius penderita otitis media supuratif kronis tanpa kolesteatoma

Sari

Soemantri

Retnoningsih

2015

Oto Rhino Laryn Indones

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Latar belakang: Otitis Media Supuratif Kronik (OMSK) adalah radang telinga tengah dengan perforasi membran timpani dan keluarnya sekret lebih dari 2 bulan. Pengobatan OMSK saat ini masih belum memuaskan. Peneliti mengharapkan dengan kelebihan dari N–asetilsistein (NAC) dapat memperbaiki transpor mukosilia tuba Eustachius. Tujuan: Penelitian ini bertujuan membandingkan waktu transpor dan penurunan waktu transpor mukosilia tuba Eustachius penderita OMSK tanpa kolesteatoma sebelum dan setelah diberikan pengobatan, baik pada kelompok pemberian NAC maupun pada kelompok kontrol. Metode: Uji klinis pada 24 subjek penelitian dengan desain penelitian non randomized double blind pre post test control group dengan pendekatan cohort. Hasil: Waktu transpor mukosilia yang dinilai dengan siprofloksasin pada kelompok pemberian NAC sebelum pengobatan sebesar 683,00 detik dan setelah pengobatan sebesar 279,83 detik dengan rerata selisih sebesar 403,17 detik, sedangkan pada kelompok kontrol sebelum pengobatan 538,33 detik dan sesudah pengobatan 225,00 detik dengan rerata selisih sebesar 313,33 detik. Pada penilaian dengan Methylene blue (MB) pada kelompok pemberian NAC sebelum pengobatan sebesar 118,50 detik dan setelah pengobatan sebesar 244,25 detik dengan rerata selisih sebesar 125,75 detik, pada kelompok kontrol sebelum pengobatan 100,67 detik dan sesudah pengobatan 38,33 detik dengan rerata selisih sebesar 62,33 detik. Kesimpulan: Tidak didapatkan perbedaan yang bermakna pada waktu transpor dan penurunan waktu transpor mukosilia tuba Eustachius penderita OMSK tanpa kolesteatoma sebelum dan setelah diberikan pengobatan NAC baik pada kelompok pemberian NAC maupun kelompok kontrol. Kata kunci: OMSK tanpa kolesteatoma, transpor mukosilia, N-asetilsisteinABSTRACT Background: Chronic Suppurative Otitis Media (CSOM) is a chronic inflammation of the middle ear with tympanic membrane perforation and discharges, for more than 2 months. Treatment of CSOM is still unsatisfactory. We hoped that N–acetylsistein (NAC) could improve the mucociliary transport of Eustachian tube. Purpose: To compare mucociliary transport time and the decrease of Eustachian tube mucociliary transport time in patients after and before treatment between NAC treated group and control group. Method: This was a randomized double blind pre and post test control group clinical trial with cohort approach involving 24 subjects. Result: Mucociliary transport time subjectively in NAC-treated group before and after NAC therapy were 683,00 seconds and 279,83 seconds respectively, with mean difference -403,17 seconds. Mucociliary transport time in control group before and after therapy were 538,33 seconds and 225,00 seconds respectively, with mean difference -313,33 seconds. Mucociliary transport time objectively in NAC-treated group before and after NAC therapy were 118,50 seconds and 244,25 seconds respectively, with mean difference -125,75 seconds. Mucociliary transport time in control group before and after therapy were 100,67 seconds and 38,33 seconds respectively, with mean difference -62,33 seconds. Conclusion: There was no significant difference of mucociliary transport time and the decrease of mucociliary transport time of Eustachian tube in CSOM without cholesteatoma before and after NAC treatment in both of group Keywords: CSOM without cholesteatoma, mucociliary transport, N-acetylcysteine

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Pengaruh pengobatan konservatif terhadap “mucociliar clearance” tuba Eustachius penderita OMSK benigna aktif

Cited by 2 publications

References 1 publication

Erdosteine for mucociliary transport in benign chronic suppurative otitis media

Erdosteine for mucociliary transport in benign chronic suppurative otitis media

Pengaruh N–asetilsistein terhadap transpor mukosilia tuba Eustachius penderita otitis media supuratif kronis tanpa kolesteatoma

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