Peran Eritropoetin pada Anemia Prematuritas

Sartika, Ika; Retayasa, Wayan; Kardana, Made; Mudita, Ida Bagus

doi:10.14238/sp9.6.2008.375-80

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…13 Erythropoietin enhances the ability to defend, proliferate and differentiate erythroid progenitor during erythropoiesis, therefore it promotes the formation of erythrocyte. 14 The number of erythrocyte in group B was shown to be statistically different than those in group C. Eryhtrocyte number in group C was lower than normal due to hypeglicemic condition in diabetes mellitus which instigates the glycation of protein. Protein glycation is a binding process between high concentration of protein amine group and glucose aldehyde group which is also known as Maillard reaction.…”

Section: Discussionmentioning

confidence: 80%

Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model

et al. 2023

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Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models.

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Section: Discussionmentioning

confidence: 80%

Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model

et al. 2023

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“…Kadar oksigen yang rendah akan mengaktifkan ginjal untuk mensekresikan eritropoeitin (Epo) dalam jumlah besar menuju darah. Kadar Epo yang tinggi akan mengaktifkan pembentukan eritrosit dalam sumsum tulang melalui peningkatan survival, proliferasi dan diferensiasi progenitor eritroid (Sartika et al, 2008). Berdasarkan hal tersebut, maka pembentukan hemoglobin berkorelasi dengan jumlah eritrosit karena hemoglobin dibentuk dalam eritrosit.…”

Section: Pembahasan Pengaruh Paparan Asap Rokok Elektrik Terhadap Kadar Hemoglobin Dan Rata-rata Jumlah Eritrosit Mencitunclassified

Profil hematologi mencit (Mus musculus L.) strain Balb/c jantan akibat paparan asap rokok elektrik

Utami¹,

Risqillah²,

Fajariah³

2020

JBIOUNUD

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Electronic cigarette is one type of cigarette that are popular. This is because of the nicotine content in electronic cigarette liquid that can be regulated by the user so it is considered safe. The purpose of this study was to analize electronic cigarette effect on hematology profile of male Balb’C mice (Mus musculus L). This study used 24 males mice which were divided into 4 groups. Group 1 (control) was the group without electronic cigarette exposure. The group 2,3, and 4 were exposed to electronic cigarette for 1 ml, 2 ml and 4 ml liquid respectively. This study use liquid that containing 6 mg nicotin/ml. The exposure to electronic cigarette were conducted for 4 weeks. Hematology profile observation include hemoglobin level, erytrocytes count, count and types of leukocytes.The result showed that hemoglobin level and erytrocytes count was increase, leukocytes and lymphocyte count was decrease and no effect on granulocytes and MID after electronic cigarette exposure using different liquid volume. The conclusion of this study was electronic cigarette exposure with different liquid volume as long as four weeks affect to Balb’C male mice hematology profile.

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Peran Eritropoetin pada Anemia Prematuritas

Cited by 2 publications

References 16 publications

Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model

Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model

Profil hematologi mencit (Mus musculus L.) strain Balb/c jantan akibat paparan asap rokok elektrik

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