Perbedaan Kebutuhan Transfusi Darah Selama  Fase Induksi pada Leukemia Limfoblastik Akut

Nency, Yetty Movieta

doi:10.14238/sp13.4.2011.271-4

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Hasil penelitian yang dilakukan di Rumah Sakit Kariadi Semarang juga menyebutkan hal yang sama bahwa ratio pada anak laki-laki lebih tinggi dari anak perempuan pada pasien LLA. 17 Hasil analisis juga memperlihatkan bahwa pasien dengan risiko standar lebih tinggi persentasenya (54,8%) dibandingkan dengan risiko tinggi (45,2%). Penelitian yang dilakukan di RSU Dr. Soetomo Surabaya juga mendapatkan bahwa pasien dengan risiko standar lebih banyak dari risiko tinggi.…”

Section: Metode Penelitianunclassified

Perubahan status gizi pada anak dengan leukemia limfoblastik akut selama pengobatan

Wolley¹,

Gunawan²,

Warouw³

2016

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Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. Study of malnutrition prevalence in children with cancer is determined by nutritional status in the early diagnosis. This is important because it can affect patient’s progress before the treatment begins. This study aimed to determine the nutritional status alteration in children with ALL during treatment. This was a descriptive analytical study with a cohort-restrospective design in ALL patients during treatment at Pediatric Department of Prof. Dr. R. D. Kandou Hospital Manado during period January 2006 to August 2013. Data were obtained from medical records of Prof. Dr. R. D. Kandou Hospital Manado. There were 31 respondents suffered from ALL at the age of 1 to 11 years old; males were more frquent than females. There were 17 respondents at standard risk while 14 respondents were at high risk. The results result of paired t-test showed that t-value < table value. Conclusion: There was a significant increase of nutritional status in children with acute lymphoblastic leukemia during treatment Keywords: acute lymphoblastic leukemia, standard risk, high risk, nutritional status Abstrak: Leukemia Limfoblastik Akut (LLA) merupakan keganasan yang paling sering didiagnosis pada anak-anak. Studi prevalensi malnutrisi pada anak-anak dengan kanker ditentukan oleh status gizi pada awal diagnosis. Hal ini penting karena dapat berpengaruh pada perkembangan pasien sebelum pengobatan dimulai. Penelitina ini bertujuan untuk mengetahui perubahan status gizi pada anak dengan LLA selama pengobatan. Jenis penelitian ini deskriptif analitik dengan metode studi kohort-retrospektif terhadap pasien LLA selama pengobatan di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado selama periode Januari 2006 – Agustus 2013. Sumber data didapatkan dari rekam medik di RSUP Prof. dr. R. D. Kandou Manado. Didapatkan 31 sampel yang menderita LLA pada usia 1-11 tahun, laki-laki lebih banyak menderita LLA. Terdapat 17 sampel dengan risiko standar dan 14 sampel dengan risiko tinggi. Hasil analisis t-berpasangan menunjukan nilai t-hitung<nilai tabel. Simpulan: Terdapat peningkatan status gizi secara bermakna pada anak dengan leukemia limfoblastik akut selama pengobatan.Kata kunci: leukemia limfoblastik akut, risiko standar, risiko tinggi, status gizi

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Section: Metode Penelitianunclassified

Perubahan status gizi pada anak dengan leukemia limfoblastik akut selama pengobatan

Wolley¹,

Gunawan²,

Warouw³

2016

eCl

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“…The remaining subjects had 34.5% leukopenia, 10.9% leukocytosis and 1.8% hyperleukocytosis. In contrast, a Surabaya study reported that 23.2% of subjects had leukocytosis, with leukocyte level of > 50,000/mm 3 . Leukopenia was observed in 30% of their subjects.…”

Section: Discussionmentioning

confidence: 86%

“…1 From an epidemiological standpoint, acute leukemia occurs in 30%-40% of all childhood malignancies. [2][3][4] Standard and high-risk groups are widely known to have different outcomes, therapy, and even prognoses. The high-risk group has been linked to poor prognosis.…”

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confidence: 99%

Hematological parameters and remission induction of childhood acute lymphoblastic leukemia

Perdani

Sudarmanto

2018

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Background High-risk acute lymphoblastic leukemia (ALL) is one of the most common childhood malignancies in Indonesia. Many factors can inhibit the induction of remission. Hematological parameters are usually not normal. Identification of corresponding factors is important to increase the likelihood of successful inductions.Objective To assess for associations between hematological parameters and induction of remission in children with acute lymphoblastic leukemia.Methods Data were collected from medical records of ALL patients hospitalized in the Pediatric Ward at Dr. Kariadi Hospital from May 2014 – May 2016. Dependent variables were hemoglobin, leukocytes, platelets, and absolute neutrophil count (ANC) levels; the independent variable was induction of remission.Results Out of 55 patients, 33 (60%) had anemia, 6 (10.9%) had leukocytosis, and 1 (1.8%) had hyperleukocytosis, whereas 9 (34.5%) had leukopenia and 29 (52,7%) had normal leukocyte levels. Thirty-one subjects (56.4%) had thrombocytopenia, 15 (27.3%) had thrombocytosis, and only 9 (16.4%) patients had normal platelet counts. There were 29 (52.7%) with absolute ANC > 500, whereas 26 (47.3%) had ANC level ≤ 500. Most patients (80%) experienced remission induction, while 20% did not. There were significant associations between ANC level and induction of remission (P=0.010) as well as between platelet level and induction of remission (P= 0.033). Regression logistic test revealed that ANC level ≤ 500 was associated with a 7-fold lower remission event compared to ANC level > 500 (RR 7.147; 95%CI 1.38 to 37.14).Conclusion Lower ANC level (≤ 500) was significantly associated with lower remission compared to higher ANC level (> 500).

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“…Hasil penelitian lain di Rumah Sakit Kariadi Semarang juga menyebutkan hal yang sama yaitu ratio anak laki-laki lebih tinggi dari anak perempuan pada pasien LLA. 9 Hasil analisis juga memperlihatkan bahwa pasien dengan risiko standar lebih tinggi persentasenya (54,8%) dibandingkan dengan risiko tinggi (45,2%). Penelitian lain yang dilakukan di Rumah Sakit Umum Dr. Soetomo Surabaya juga mendapatkan bahwa pasien dengan risiko standar lebih banyak dari resiko tinggi.…”

Section: Bahasanunclassified

Perubahan Status Gizi pada Anak dengan Leukemia Limfoblastik Akut Selama Terapi

Rompies¹,

Amelia²,

Gunawan³

2019

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Nutritional status of children with acute lymphoblastic leukemia (ALL) can be altered by either chemotherapy or the leukemia itself. This study was aimed to evaluate the nutritional status alteration of ALL survivors who were treated at Estella Pediatric Cancer Care Manado. This was a cohort retrospective study involving survivors of ALL treated at Estella Pediatric Cancer Care Manado from January 2006 to December 2013. Data were collected from medical records, including body weight and height upon admission, end of induction, and at the beginning of maintenance as well as at the end of treatment. Nutritional status was assesed according to WHO 2006 and CDC 2000 growth charts. Data were analyzed using sign tests. The results showed that there were 31 ALL survivors consisted of 18 males and 13 females. Seventeen children were categorized as standard risk and 14 as high risk. A significant nutritional alteration was accrued during treatment, mainly in the induction phase (p<0.05). These consisted of 1 child who had declined nutritional status, 15 children had no change of nutritional status, and 15 children had increased nutritional status. In conclusion, there is a significant alteration of nutritional status during ALL chemotherapy.Keywords: treatment of ALL, nutritional status Abstrak: Status gizi pada anak dengan leukemia limfoblastik akut (LLA) dapat mengalami perubahan oleh karena kemoterapi atau penyakit leukemia itu sendiri. Penelitian ini bertujuan untuk mengevaluasi perubahan status gizi pada survivor LLA yang telah mendapat terapi di Pusat Kanker Anak Estella Manado. Jenis penelitian ialah kohort-retrospektif pada survivor LLA yang telah mendapatkan terapi di Pusat Kanker Anak Estella Manado dari bulan Januari 2006 sampai Desember 2013. Data dikumpulkan dari rekam medis, termasuk berat badan dan tinggi badan saat masuk rumah sakit, akhir fase induksi, saat awal pada fase maintenance, dan pada akhir dari terapi. Status gizi dinilai berdasarkan kurva WHO 2006 dan CDC 2000. Data kemudian dianalisis menggunakan test sign. Hasil penelitian mendapatkan 31 anak survivor LLA, terdiri dari 18 laki-laki dan 13 perempuan. Terdapat 17 anak yang masuk dalam kategori risiko standar dan 14 anak masuk dalam kategori risiko tinggi. Perubahan status gizi secara bermakna terjadi selama terapi, terutama pada fase induksi (p<0,05), yaitu pada akhir terapi didapatkan 1 anak dengan penurunan status gizi, 15 anak tanpa perubahan status gizi, dan 15 anak dengan peningkatan status gizi. Simpulan penelitian ini ialah terdapat perubahan yang bermakna pada status gizi selama pemberian kemoterapi LLA.Kata kunci: terapi pada LLA, status gizi

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Perbedaan Kebutuhan Transfusi Darah Selama Fase Induksi pada Leukemia Limfoblastik Akut

Cited by 4 publications

References 5 publications

Perubahan status gizi pada anak dengan leukemia limfoblastik akut selama pengobatan

Perubahan status gizi pada anak dengan leukemia limfoblastik akut selama pengobatan

Hematological parameters and remission induction of childhood acute lymphoblastic leukemia

Perubahan Status Gizi pada Anak dengan Leukemia Limfoblastik Akut Selama Terapi

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